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1.	Nilsson, Karin, et al. (författare) Plasma homocysteine-a marker of vascular disease in elderly patients with mental illness. 2010 Ingår i: Clinical Biochemistry. - : Elsevier BV. - 1873-2933 .- 0009-9120. ; 43, s. 1056-1059 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. METHOD: We investigated the influence of cobalamin/folate status and renal function on the association between plasma tHcy levels and vascular disease. RESULTS: There was a similar degree of significant difference in plasma tHcy levels between patients with and without vascular disease in all enrolled patients and in a group of patients where all those with signs of cobalamin/folate deficiency and/or impaired renal function had been excluded. Furthermore, logistic regression analysis showed that the age-adjusted plasma tHcy was the main predictor of vascular disease in both groups of patients. CONCLUSION: The findings suggest that the presence of vascular disease itself is associated with elevated levels of plasma tHcy. Plasma tHcy might be a marker of vascular disease in elderly patients with mental illness.

Nilsson, Karin, et al. (författare)
Plasma homocysteine-a marker of vascular disease in elderly patients with mental illness.
2010
Ingår i: Clinical Biochemistry. - : Elsevier BV. - 1873-2933 .- 0009-9120. ; 43, s. 1056-1059
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. METHOD: We investigated the influence of cobalamin/folate status and renal function on the association between plasma tHcy levels and vascular disease. RESULTS: There was a similar degree of significant difference in plasma tHcy levels between patients with and without vascular disease in all enrolled patients and in a group of patients where all those with signs of cobalamin/folate deficiency and/or impaired renal function had been excluded. Furthermore, logistic regression analysis showed that the age-adjusted plasma tHcy was the main predictor of vascular disease in both groups of patients. CONCLUSION: The findings suggest that the presence of vascular disease itself is associated with elevated levels of plasma tHcy. Plasma tHcy might be a marker of vascular disease in elderly patients with mental illness.

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