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  • Strand, Sven-Erik, et al. (author)
  • A general extracorporeal immunoadsorption method to increase tumor-to-tissue ratio
  • 1994
  • In: Cancer. - 1097-0142. ; 73:3 Suppl, s. 1033-1037
  • Journal article (peer-reviewed)abstract
    • The idea of applying extracorporeal immunoadsorption (ECIA) in radioimmunodiagnosis and radioimmunotherapy has been proposed previously. The authors here report on the development of new concept using a general method for ECIA based on biotinylated MoAb adsorbed on an avidin column. Athymic rats heterotransplanted with either human melanomas or human lung carcinoma were injected with iodine-125-labeled biotinylated 96.5 or L6 MoAb, respectively. At 24 or 48 hours after the injection, ECIA was performed by pumping blood through a hollow-fiber plasma filter. The separated plasma then was passed through an absorbent (avidin-agarose) column. The whole ECIA procedure lasted for 3 hours. By this ECIA method, the tumor-to-normal tissue ratios were increased in various tissues (i.e., radiosensitive and blood rich organs) by a factor of four to five.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Strand, Sven-Erik (1)
Tennvall, Jan (1)
Lindgren, L (1)
Norrgren, Kristina (1)
Garkavij, Michael (1)
Nilsson, Rune (1)
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Sjogren, H O (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
1994 (1)

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