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- Smedman, A, et al.
(författare)
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Conjugated linoleic acid increased C-reactive protein in human subjects
- 2005
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Ingår i: British Journal of Nutrition. - : Published on behalf of the Nutrition Society by CABI Publishing. - 1475-2662 .- 0007-1145. ; 94:5, s. 791-795
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Tidskriftsartikel (refereegranskat)abstract
- We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.
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