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  • Hansen, Jesper S., et al. (author)
  • Visualization of lipid directed dynamics of perilipin 1 in human primary adipocytes
  • 2017
  • In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
  • Journal article (peer-reviewed)abstract
    • Perilipin 1 is a lipid droplet coating protein known to regulate lipid metabolism in adipocytes by serving as a physical barrier as well as a recruitment site for lipases to the lipid droplet. Phosphorylation of perilipin 1 by protein kinase A rapidly initiates lipolysis, but the detailed mechanism on how perilipin 1 controls lipolysis is unknown. Here, we identify specific lipid binding properties of perilipin 1 that regulate the dynamics of lipolysis in human primary adipocytes. Cellular imaging combined with biochemical and biophysical analyses demonstrate that perilipin 1 specifically binds to cholesteryl esters, and that their dynamic properties direct segregation of perilipin 1 into topologically distinct micro domains on the lipid droplet. Together, our data points to a simple unifying mechanism that lipid assembly and segregation control lipolysis in human primary adipocytes.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Göransson, Olga (1)
Lindkvist-Petersson, ... (1)
de Mare, Sofia (1)
Hansen, Jesper S. (1)
Jones, Helena A. (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2017 (1)

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