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  • Burman, Pia, et al. (author)
  • Temozolomide therapy for aggressive pituitary tumours – current understanding and future perspectives
  • 2020
  • In: Reviews in Endocrine and Metabolic Disorders. - : Springer Science and Business Media LLC. - 1389-9155 .- 1573-2606. ; 21:2, s. 263-276
  • Research review (peer-reviewed)abstract
    • The use of temozolomide (TMZ) for the management of aggressive pituitary tumours (APT) has revolutionised clinical practice in this field with significantly improved clinical outcomes and long-term survival. Its use is now well established however a large number of patients do not respond to treatment and recurrence after cessation of TMZ is common. A number of challenges remain for clinicians such as appropriate patient selection, treatment duration and the role of combination therapy. This review will examine the use of TMZ to treat APT including mechanism of action, treatment regimen and duration; biomarkers predicting response to treatment and patient selection; and current evidence for administration of TMZ in combination with other agents.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
Burman, Pia (1)
Lamb, Lydia (1)
McCormack, Ann (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2020 (1)

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