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  • Xie, Xiao-Qi, et al. (author)
  • AML and Ets proteins regulate the I alpha1 germ-line promoter.
  • 1999
  • In: European Journal of Immunology. - 0014-2980 .- 1521-4141. ; 29:2, s. 488-498
  • Journal article (peer-reviewed)abstract
    • The immunoglobulin heavy chain (IgH) class switch recombination of B lymphocytes preferentially targets unrearranged IgH genes that have already been rendered transcriptionally active. Transcription of the germ-line IgH genes is controlled by intervening (I) regions upstream of their switch regions. The I alpha1 promoter activates transcription of the human germ-line C alpha1 gene for IgA1 and mediates the transforming growth factor (TGF)-beta1 responsiveness of this locus. Here we show that the I alpha1 promoter contains several binding sites for the AML/PEBP2/CBF family of transcription factors and that AML and Ets proteins are major regulators of the basal and TGF-beta-inducible promoter activity. Our data constitute a starting point for studies to elucidate the molecular mechanism by which TGF-beta regulates IgA production.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Holm, Magnus (1)
Grundström, Thomas (1)
Pardali, Evangelia (1)
Sideras, Paschalis (1)
Xie, Xiao-Qi (1)
University
Umeå University (1)
Language
English (1)
Year
1999 (1)

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