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  • Bergman, Olle, 1978, et al. (author)
  • Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia
  • 2010
  • In: Progress in Neuro-psychopharmacology and Biological Psychiatry. - : Elsevier. - 0278-5846 .- 1878-4216. ; 34:6, s. 1094-1097
  • Journal article (peer-reviewed)abstract
    • The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the development and/or the maintenance of dopaminergic neurons prompted us to investigate if five single nucleotide polymorphisms (SNPs) previously linked to Parkinson's disease are associated with this disorder. Preliminary evidence that genetic variation in LMX1A (rs6668493, rs4657411), LMX1B (rs10987386) and PITX3 (rs4919621) may increase the risk of developing schizophrenia is presented.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Adolfsson, Rolf (1)
Eriksson, Elias, 195 ... (1)
Nilsson, Lars-Göran (1)
Westberg, Lars, 1973 (1)
Bergman, Olle, 1978 (1)
University
University of Gothenburg (1)
Umeå University (1)
Stockholm University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Social Sciences (1)
Year
2010 (1)

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