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  • Sommer, Morten O. A., et al. (author)
  • Prediction of antibiotic resistance : time for a new preclinical paradigm?
  • 2017
  • In: Nature Reviews Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 15:11, s. 688-695
  • Research review (peer-reviewed)abstract
    • Predicting the future is difficult, especially for evolutionary processes that are influenced by numerous unknown factors. Still, this is what is required of drug developers when they assess the risk of resistance arising against a new antibiotic candidate during preclinical development. In this Opinion article, we argue that the traditional procedures that are used for the prediction of antibiotic resistance today could be markedly improved by including a broader analysis of bacterial fitness, infection dynamics, horizontal gene transfer and other factors. This will lead to more informed preclinical decisions for continuing or discontinuing the development of drug candidates.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
Andersson, Dan I. (1)
Munck, Christian (1)
Sommer, Morten O. A. (1)
Toft-Kehler, Rasmus ... (1)
University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2017 (1)

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