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- Wisniewska, M, et al.
(författare)
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Detection of specific Helicobacter pylori DNA and antigens in stool samples in dyspeptic patients and healthy subjects
- 2002
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Ingår i: Microbiology and Immunology. - 1348-0421. ; 46:10, s. 657-665
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Tidskriftsartikel (refereegranskat)abstract
- In this study stool samples from dyspeptic patients and healthy subjects were used for detection of specific Helicobacter pylori antigens and DNA by immunoenzymatic test (PPHpSA) and semi-nested PCR (ureA-PCR), respectively. The H. pylori status was estimated by invasive endoscopy-based rapid urease test and histology or noninvasive urea breath test (UBT), and by serology (ELISA, Western blot). The coincidence of IT pylori-negative invasive tests or UBT and negative antigen or DNA stool tests was very high (mean 95%). The PPHpSA results were found positive for 56% and ureA-PCR for 26% of individuals with H. pylori infection confirmed by invasive tests or UBT. The detection of specific H. pylori antigens and especially DNA in feces is not sufficient as a one-step diagnosis of H. pylori infection.
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