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1.	Urowitz, M B, et al. (author) Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort 2007 In: Lupus. - : SAGE Publications. - 0961-2033 .- 1477-0962. ; 16:9, s. 731-735 Journal article (peer-reviewed)abstract Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Fortin, P. (1); Sturfelt, Gunnar (1); Ramsey-Goldman, R (1); Isenberg, D (1); Steinsson, K (1); van Vollenhoven, R (1); show more...; Clarke, A. (1); Bernatsky, S (1); Nived, Ola (1); Zoma, A. (1); Wallace, D. (1); Khamashta, M (1); Buyon, J (1); Aranow, C (1); Gordon, C. (1); Petri, M. (1); Sanchez-Guerrero, J (1); Manzi, S (1); Stoll, T (1); Maddison, P (1); Ginzler, E (1); Gladman, D (1); Dooley, M A (1); Alarcon, G (1); Hanly, J (1); Font, J. (1); Bruce, I (1); Urowitz, M. B. (1); Merrill, J. (1); Bae, S (1); Kalunian, K (1); Ibanez, D (1); show less...

University: Lund University (1); Karolinska Institutet (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2007 (1)

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