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  • Wilson, C. A., et al. (author)
  • IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat
  • 1990
  • In: Journal of Immunology. - 0022-1767. ; 144:10, s. 3784-3788
  • Journal article (peer-reviewed)abstract
    • Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Baker, P. (1)
Wilson, D (1)
LERNMARK, A (1)
Jacobs, C (1)
Toivola, B. (1)
Baskin, D. G. (1)
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Wilson, C. A. (1)
Dower, S. (1)
Vertrees, S. (1)
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University
Lund University (1)
Language
English (1)
Year
1990 (1)

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