| 1301. |
- Bustamante, Mercedes, et al.
(författare)
-
Ten new insights in climate science 2023
- 2023
-
Ingår i: Global Sustainability. - : CAMBRIDGE UNIV PRESS. - 2059-4798. ; 7
-
Forskningsöversikt (refereegranskat)abstract
- Non-technical summary We identify a set of essential recent advances in climate change research with high policy relevance, across natural and social sciences: (1) looming inevitability and implications of overshooting the 1.5 degrees C warming limit, (2) urgent need for a rapid and managed fossil fuel phase-out, (3) challenges for scaling carbon dioxide removal, (4) uncertainties regarding the future contribution of natural carbon sinks, (5) intertwinedness of the crises of biodiversity loss and climate change, (6) compound events, (7) mountain glacier loss, (8) human immobility in the face of climate risks, (9) adaptation justice, and (10) just transitions in food systems.Technical summary The Intergovernmental Panel on Climate Change Assessment Reports provides the scientific foundation for international climate negotiations and constitutes an unmatched resource for researchers. However, the assessment cycles take multiple years. As a contribution to cross- and interdisciplinary understanding of climate change across diverse research communities, we have streamlined an annual process to identify and synthesize significant research advances. We collected input from experts on various fields using an online questionnaire and prioritized a set of 10 key research insights with high policy relevance. This year, we focus on: (1) the looming overshoot of the 1.5 degrees C warming limit, (2) the urgency of fossil fuel phase-out, (3) challenges to scale-up carbon dioxide removal, (4) uncertainties regarding future natural carbon sinks, (5) the need for joint governance of biodiversity loss and climate change, (6) advances in understanding compound events, (7) accelerated mountain glacier loss, (8) human immobility amidst climate risks, (9) adaptation justice, and (10) just transitions in food systems. We present a succinct account of these insights, reflect on their policy implications, and offer an integrated set of policy-relevant messages. This science synthesis and science communication effort is also the basis for a policy report contributing to elevate climate science every year in time for the United Nations Climate Change Conference.Social media summary We highlight recent and policy-relevant advances in climate change research - with input from more than 200 experts.
|
|
| 1302. |
- Chen, Chi-Hua, et al.
(författare)
-
Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure
- 2017
-
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- Discovering genetic variants associated with human brain structures is an on-going effort. The ENIGMA consortium conducted genome-wide association studies (GWAS) with standard multi-study analytical methodology and identified several significant single nucleotide polymorphisms (SNPs). Here we employ a novel analytical approach that incorporates functional genome annotations (e.g., exon or 5′UTR), total linkage disequilibrium (LD) scores and heterozygosity to construct enrichment scores for improved identification of relevant SNPs. The method provides increased power to detect associated SNPs by estimating stratum-specific false discovery rate (FDR), where strata are classified according to enrichment scores. Applying this approach to the GWAS summary statistics of putamen volume in the ENIGMA cohort, a total of 15 independent significant SNPs were identified (conditional FDR < 0.05). In contrast, 4 SNPs were found based on standard GWAS analysis (P < 5 × 10−8). These 11 novel loci include GATAD2B, ASCC3, DSCAML1, and HELZ, which are previously implicated in various neural related phenotypes. The current findings demonstrate the boost in power with the annotation-informed FDR method, and provide insight into the genetic architecture of the putamen.
|
|
| 1303. |
|
|
| 1304. |
|
|
| 1305. |
- Garnsworthy, A. B., et al.
(författare)
-
Spectroscopy of Po-212 and At-213 using a He-8 radioactive beam and EXOGAM
- 2005
-
Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 31:10, s. S1851-S1854
-
Tidskriftsartikel (refereegranskat)abstract
- A beam of 28 MeV He-8 particles with an average intensity 2 x 10(5) ions s(-1), produced by the SPIRAL facility at GANIL, was used to initiate fusion-evaporation reactions in thick targets of Pb-201 and Bi-209. Excited states of Po-212 and At-213 were populated in (He-8,4n) reactions. The emitted gamma-rays were detected using the EXOGAM array composed of four Compton suppressed germanium Clover detectors in a close geometry configuration. Preliminary results show that Po-212 has been populated to high spin (I similar or equal to 14) with a significantly increased yield compared with our previous He-8 beam experiment. An apparently increased relative population of states up to 12(+) was observed compared with published results from a Pb-208(Be-9,alpha n)(212) Po reaction at 48 MeV. Evidence is presented for a previously unreported de-excitation pathway: 69 keV (13(-) -> 12(+)). States up to I-pi = (39/2(-)) have also been observed in At-213.
|
|
| 1306. |
|
|
| 1307. |
|
|
| 1308. |
- Graslund, S, et al.
(författare)
-
Protein production and purification
- 2008
-
Ingår i: Nature methods. - : Springer Science and Business Media LLC. - 1548-7105 .- 1548-7091. ; 5:2, s. 135-146
-
Tidskriftsartikel (refereegranskat)
|
|
| 1309. |
|
|
| 1310. |
|
|
