| 11. |
- Butterworth, J., et al.
(författare)
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Les Houches 2013: Physics at TeV Colliders: Standard Model Working Group Report
- 2014
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Konferensbidrag (refereegranskat)abstract
- This Report summarizes the proceedings of the 2013 Les Houches workshop on Physics at TeV Colliders. Session 1 dealt primarily with (1) the techniques for calculating standard model multi-leg NLO and NNLO QCD and NLO EW cross sections and (2) the comparison of those cross sections with LHC data from Run 1, and projections for future measurements in Run 2.
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| 12. |
- Chiesa, Marco, 1987-, et al.
(författare)
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Local transit policies and the complexity of BGP Stability Testing
- 2011
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Ingår i: INFOCOM, 2011 Proceedings IEEE. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781424499212 ; , s. 2957-2965
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Konferensbidrag (refereegranskat)abstract
- BGP, the core protocol of the Internet backbone, is renowned to be prone to oscillations. Despite prior work shed some light on BGP stability, many problems remain open. For example, determining how hard it is to check that a BGP network is safe, i.e., it is guaranteed to converge, has been an elusive research goal up to now. In this paper, we address several problems related to BGP stability, stating the computational complexity of testing if a given configuration is safe, is robust, or is safe under filtering. Further, we determine the computational complexity of checking popular sufficient conditions for stability. We adopt a model that captures Local Transit policies, i.e., policies that are functions only of the ingress and the egress points. The focus on Local Transit policies is motivated by the fact that they represent a configuration paradigm commonly used by network operators. We also address the same BGP stability problems in the widely adopted SPP model. Unfortunately, we find that the most interesting problems are computationally hard even if policies are restricted to be as expressive as Local Transit policies. Our findings suggest that the computational intractability of BGP stability be an intrinsic property of policy-based path vector routing protocols that allow policies to be specified in complete autonomy.
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| 13. |
- Chiesa, Marco, 1987-, et al.
(författare)
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Using routers to build logic circuits : How powerful is BGP?
- 2013
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Ingår i: 2013 21st IEEE International Conference on Network Protocols (ICNP). - : IEEE Computer Society. - 9781479912704
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Konferensbidrag (refereegranskat)abstract
- Because of its practical relevance, the Border Gateway Protocol (BGP) has been the target of a huge research effort since more than a decade. In particular, many contributions aimed at characterizing the computational complexity of BGP-related problems. In this paper, we answer computational complexity questions by unveiling a fundamental mapping between BGP configurations and logic circuits. Namely, we describe simple networks containing routers with elementary BGP configurations that simulate logic gates, clocks, and flip-flops, and we show how to interconnect them to simulate arbitrary logic circuits. We then investigate the implications of such a mapping on the feasibility of solving BGP fundamental problems, and prove that, under realistic assumptions, BGP has the same computing power as a Turing Machine. We also investigate the impact of restrictions on the expressiveness of BGP policies and route propagation (e.g., route propagation rules in iBGP and Local Transit Policies in eBGP) and the impact of different message timing models. Finally, we show that the mapping is not limited to BGP and can be applied to generic routing protocols that use several metrics.
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| 14. |
- Coelho, Teresa, et al.
(författare)
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Safety and efficacy of RNAi therapy for transthyretin amyloidosis
- 2013
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Ingår i: The New England journal of medicine. - 1533-4406. ; 369:9, s. 819-29
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived transthyretin amyloid in peripheral nerves and the heart. A therapeutic approach mediated by RNA interference (RNAi) could reduce the production of transthyretin. METHODS: We identified a potent antitransthyretin small interfering RNA, which was encapsulated in two distinct first- and second-generation formulations of lipid nanoparticles, generating ALN-TTR01 and ALN-TTR02, respectively. Each formulation was studied in a single-dose, placebo-controlled phase 1 trial to assess safety and effect on transthyretin levels. We first evaluated ALN-TTR01 (at doses of 0.01 to 1.0 mg per kilogram of body weight) in 32 patients with transthyretin amyloidosis and then evaluated ALN-TTR02 (at doses of 0.01 to 0.5 mg per kilogram) in 17 healthy volunteers. RESULTS: Rapid, dose-dependent, and durable lowering of transthyretin levels was observed in the two trials. At a dose of 1.0 mg per kilogram, ALN-TTR01 suppressed transthyretin, with a mean reduction at day 7 of 38%, as compared with placebo (P=0.01); levels of mutant and nonmutant forms of transthyretin were lowered to a similar extent. For ALN-TTR02, the mean reductions in transthyretin levels at doses of 0.15 to 0.3 mg per kilogram ranged from 82.3 to 86.8%, with reductions of 56.6 to 67.1% at 28 days (P<0.001 for all comparisons). These reductions were shown to be RNAi-mediated. Mild-to-moderate infusion-related reactions occurred in 20.8% and 7.7% of participants receiving ALN-TTR01 and ALN-TTR02, respectively. CONCLUSIONS: ALN-TTR01 and ALN-TTR02 suppressed the production of both mutant and nonmutant forms of transthyretin, establishing proof of concept for RNAi therapy targeting messenger RNA transcribed from a disease-causing gene. (Funded by Alnylam Pharmaceuticals; ClinicalTrials.gov numbers, NCT01148953 and NCT01559077.).
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| 15. |
- Leblond, Claire S, et al.
(författare)
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Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments.
- 2014
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 10:9
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Tidskriftsartikel (refereegranskat)abstract
- SHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses. In neurons, SHANK2 and SHANK3 have a positive effect on the induction and maturation of dendritic spines, whereas SHANK1 induces the enlargement of spine heads. Mutations in SHANK genes have been associated with autism spectrum disorders (ASD), but their prevalence and clinical relevance remain to be determined. Here, we performed a new screen and a meta-analysis of SHANK copy-number and coding-sequence variants in ASD. Copy-number variants were analyzed in 5,657 patients and 19,163 controls, coding-sequence variants were ascertained in 760 to 2,147 patients and 492 to 1,090 controls (depending on the gene), and, individuals carrying de novo or truncating SHANK mutations underwent an extensive clinical investigation. Copy-number variants and truncating mutations in SHANK genes were present in ∼1% of patients with ASD: mutations in SHANK1 were rare (0.04%) and present in males with normal IQ and autism; mutations in SHANK2 were present in 0.17% of patients with ASD and mild intellectual disability; mutations in SHANK3 were present in 0.69% of patients with ASD and up to 2.12% of the cases with moderate to profound intellectual disability. In summary, mutations of the SHANK genes were detected in the whole spectrum of autism with a gradient of severity in cognitive impairment. Given the rare frequency of SHANK1 and SHANK2 deleterious mutations, the clinical relevance of these genes remains to be ascertained. In contrast, the frequency and the penetrance of SHANK3 mutations in individuals with ASD and intellectual disability-more than 1 in 50-warrant its consideration for mutation screening in clinical practice.
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| 16. |
- Walsh, F., et al.
(författare)
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Artificial backbone neuronal network for nano scale sensors
- 2011
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Ingår i: 2011 IEEE Conference on Computer Communications Workshops, INFOCOM WKSHPS 2011. Shanghai, 10-15 April 2011. - 9781457702488 ; , s. 449-454
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Konferensbidrag (refereegranskat)abstract
- Communication between biological based nano scale devices is a crucial component of future applications in nanotechnology. This paper explores the creation of a backbone communication network for nano scale sensors using neurons. We investigate how neuron cell characteristics affect the performance of neuronal based network and highlight several key characteristics compared to conventional wire based networks. Finally, we investigate four network topologies through simulation.
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