| 11. |
- Skantzakis, E., et al.
(författare)
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Non-linear Extreme Ultraviolet Applications with Attosecond Pulses
- 2024
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Ingår i: Topics in Applied Physics. - 1437-0859 .- 0303-4216. - 9783031554629 - 9783031554636 ; 151, s. 1-24
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Bokkapitel (refereegranskat)abstract
- In recent years laser driven attosecond sourcesAttosecond sources based on loose geometry high order harmonic generationHigh order harmonic generation reach focused intensities as high as to induce multi-photonMulti-photonmultiple ionizationMultiple ionization or even strong -field effectsEven strong-field effects in the extreme ultraviolet spectral range. In this chapter, we review four such sources developed through collaborative efforts between FORTH, ELI-ALPS and the University of Lund together with recent results obtained in the above mentioned topics utilizing these sources.
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| 12. |
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| 13. |
- Sola, I. J., et al.
(författare)
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Temporal and spectral studies of high-order harmonics generated by polarization-modulated infrared fields
- 2006
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 74:1
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Tidskriftsartikel (refereegranskat)abstract
- The temporal confinement of high harmonic generation (HHG) via modulation of the polarization of the fundamental pulse is studied in both temporal and spectral domains. In the temporal domain, a collinear cross-correlation setup using a 40 fs IR pump for the HHG and a 9 fs IR pulse to probe the generated emission is used to measure the XUV pulse duration. The observed temporal confinement is found to be consistent with theoretical predictions. An increased confinement is observed when a 9 fs pulse is used to generate the harmonics. An important spectral broadening, including a continuum background, is also measured. Theoretical calculations show that with 10 fs driving pulses, either one or two main attosecond pulses are created depending on the value of the carrier envelope phase.
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| 14. |
- Zaïr, A., et al.
(författare)
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Confinement of attosecond train pulses by using a modulated polarization IR pulse
- 2005
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Ingår i: 2005 Conference on Lasers and Electro-Optics Europe. - 0780389743 - 9780780389748
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Konferensbidrag (refereegranskat)abstract
- We study the temporal and spectral behaviour of high order harmonics generated by pulses with temporally modulated polarization. We observe a harmonic temporal confinement and a harmonic spectral broadening, compatible with 1 -or-2 attosecond pulse emission.
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| 15. |
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| 16. |
- Zettergren, Henning, et al.
(författare)
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Roadmap on dynamics of molecules and clusters in the gas phase
- 2021
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Ingår i: European Physical Journal D. - : Springer Science and Business Media LLC. - 1434-6060 .- 1434-6079. ; 75:5
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Tidskriftsartikel (refereegranskat)abstract
- This roadmap article highlights recent advances, challenges and future prospects in studies of the dynamics of molecules and clusters in the gas phase. It comprises nineteen contributions by scientists with leading expertise in complementary experimental and theoretical techniques to probe the dynamics on timescales spanning twenty order of magnitudes, from attoseconds to minutes and beyond, and for systems ranging in complexity from the smallest (diatomic) molecules to clusters and nanoparticles. Combining some of these techniques opens up new avenues to unravel hitherto unexplored reaction pathways and mechanisms, and to establish their significance in, e.g. radiotherapy and radiation damage on the nanoscale, astrophysics, astrochemistry and atmospheric science.
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| 17. |
- Arnold, C. L., et al.
(författare)
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Stabilized interferometric attosecond timing measurements
- 2013
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Ingår i: CLEO : QELS_Fundamental Science, CLEO:QELS FS 2013 - QELS_Fundamental Science, CLEO:QELS FS 2013. - 9781557529725
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Konferensbidrag (refereegranskat)abstract
- We perform interferometric attosecond timing measurements to study XUV photoionization in noble gases, to diagnose macroscopic phase-matching conditions in high-order harmonic generation, and to investigate single-photon double-ionization by detecting electron pairs in coincidence.
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| 18. |
- Berggård, Karin, et al.
(författare)
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Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes
- 2001
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Ingår i: Molecular Microbiology. - : Wiley. - 1365-2958 .- 0950-382X. ; 42:2, s. 539-551
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Tidskriftsartikel (refereegranskat)abstract
- The amino-terminal hypervariable region (HVR) of streptococcal M protein is required for the ability of this virulence factor to confer phagocytosis resistance. The function of the HVR has remained unknown, but the finding that many HVRs with extremely divergent sequences bind the human complement regulator C4b-binding protein (C4BP) has suggested that this ligand may play a role in phagocytosis resistance. We used the M22 system to study the function of bound C4BP and provide several lines of evidence that C4BP indeed contributes to phagocytosis resistance. First, the ability of anti-HVR antibodies to cause opsonization correlated with their ability to inhibit binding of C4BP. Secondly, a short deletion in the HVR eliminated C4BP binding and also reduced the ability of M22 to confer phagocytosis resistance. Thirdly, the addition of an excess of pure C4BP to a phagocytosis system almost completely blocked the effect of opsonizing anti-HVR antibodies. Together, our data indicate that binding of C4BP to the HVR of M22 plays an important role in phagocytosis resistance, but other properties of M22 also contribute. This study provides the first molecular insight into the mechanisms by which the HVR of an M protein confers phagocytosis resistance.
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| 19. |
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| 20. |
- Buckley, Patrick G, et al.
(författare)
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A full-coverage, high-resolution human chromosome 22 genomic microarrayfor clinical and research applications
- 2002
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 11:25, s. 3221-3229
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Tidskriftsartikel (refereegranskat)abstract
- We have constructed the first comprehensive microarray representing a human chromosome for analysis of DNA copy number variation. This chromosome 22 array covers 34.7 Mb, representing 1.1% of the genome, with an average resolution of 75 kb. To demonstrate the utility of the array, we have applied it to profile acral melanoma, dermatofibrosarcoma, DiGeorge syndrome and neurofibromatosis 2. We accurately diagnosed homozygous/heterozygous deletions, amplifications/gains, IGLV/IGLC locus instability, and breakpoints of an imbalanced translocation. We further identified the 14-3-3 eta isoform as a candidate tumor suppressor in glioblastoma. Two significant methodological advances in array construction were also developed and validated. These include a strictly sequence defined, repeat-free, and non-redundant strategy for array preparation. This approach allows an increase in array resolution and analysis of any locus; disregarding common repeats, genomic clone availability and sequence redundancy. In addition, we report that the application of phi29 DNA polymerase is advantageous in microarray preparation. A broad spectrum of issues in medical research and diagnostics can be approached using the array. This well annotated and gene-rich autosome contains numerous uncharacterized disease genes. It is therefore crucial to associate these genes to specific 22q-related conditions and this array will be instrumental towards this goal. Furthermore, comprehensive epigenetic profiling of 22q-located genes and high-resolution analysis of replication timing across the entire chromosome can be studied using our array.
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