| 11. |
- Weiner, D. J., et al.
(author)
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
- 2017
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:7
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Journal article (peer-reviewed)abstract
- Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.
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| 12. |
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| 13. |
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| 14. |
- Aaboud, M, et al.
(author)
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Measurement of fiducial and differential W+W- production cross-sections at √s=13 TeV with the ATLAS detector
- 2019
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:10
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Journal article (peer-reviewed)abstract
- A measurement of fiducial and differential cross-sections for W+W- production in proton–proton collisions at s=13 TeV with the ATLAS experiment at the Large Hadron Collider using data corresponding to an integrated luminosity of 36.1 fb - 1 is presented. Events with one electron and one muon are selected, corresponding to the decay of the diboson system as WW→ e±νμ∓ν. To suppress top-quark background, events containing jets with a transverse momentum exceeding 35 GeV are not included in the measurement phase space. The fiducial cross-section, six differential distributions and the cross-section as a function of the jet-veto transverse momentum threshold are measured and compared with several theoretical predictions. Constraints on anomalous electroweak gauge boson self-interactions are also presented in the framework of a dimension-six effective field theory. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 15. |
- Abulaiti, Yiming, et al.
(author)
-
Measurement of WW/WZ -> lvqq ' production with the hadronically decaying boson reconstructed as one or two jets in pp collisions at root s=8 TeV with ATLAS, and constraints on anomalous gauge couplings
- 2017
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:8
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Journal article (peer-reviewed)abstract
- This paper presents a study of the production of WW or WZ boson pairs, with one W boson decaying to ev or mu v and one W or Z boson decaying hadronically. The analysis uses 20.2 fb(-1) of root s = 8 TeV pp collision data, collected by the ATLAS detector at the Large Hadron Collider. Crosssections for WW/WZ production are measured in high-p(T) fiducial regions defined close to the experimental event selection. The cross-section is measured for the case where the hadronically decaying boson is reconstructed as two resolved jets, and the case where it is reconstructed as a single jet. The transverse momentum distribution of the hadronically decaying boson is used to search for new physics. Observations are consistent with the Standard Model predictions, and 95% confidence intervals are calculated for parameters describing anomalous triple gauge-boson couplings.
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| 16. |
- Abulaiti, Yiming, et al.
(author)
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Search for a scalar partner of the top quark in the jets plus missing transverse momentum final state at root s=13 TeV with the ATLAS detector
- 2017
-
In: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :12
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Journal article (peer-reviewed)abstract
- A search for pair production of a scalar partner of the top quark in events with four or more jets plus missing transverse momentum is presented. An analysis of 36.1 fb(-1) of root s = 13 TeV proton-proton collisions collected using the ATLAS detector at the LHC yields no significant excess over the expected Standard Model background. To interpret the results a simplified supersymmetric model is used where the top squark is assumed to decay via (t) over tilde (1) -> t((*)) (chi) over tilde (0)(1) and (t) over tilde (1) -> b (chi) over tilde (+/-)(1) -> bW((*)) (chi) over tilde (0)(1), where (chi) over tilde (0)(1) ((chi) over tilde (+/-)(1) denotes the lightest neutralino (chargino). Exclusion limits are placed in terms of the top-squark and neutralino masses. Assuming a branching ratio of 100% to t (chi) over tilde (0)(1), top-squark masses in the range 450-1000 GeV are excluded for (chi) over tilde (0)(1) masses below 160 GeV. In the case where m((t) over tilde1) similar to m(t) + m((chi) over tilde 10), top-squark masses in the range 235-590 GeV are excluded.
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| 17. |
- Abulaiti, Yiming, et al.
(author)
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Search for dark matter in association with a Higgs boson decaying to two photons at root s=13 TeV with the ATLAS detector
- 2017
-
In: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:11
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Journal article (peer-reviewed)abstract
- A search for dark matter in association with a Higgs boson decaying to two photons is presented. This study is based on data collected with the ATLAS detector, corresponding to an integrated luminosity of 36.1 fb(-1) of proton-proton collisions at the LHC at a center-of-mass energy of 13 TeV in 2015 and 2016. No significant excess over the expected background is observed. Upper limits at 95% confidence level are set on the visible cross section for beyond the Standard Model physics processes, and the production cross section times branching fraction of the Standard Model Higgs boson decaying into two photons in association with missing transverse momentum in three different benchmark models. Limits at 95% confidence level are also set on the observed signal in two-dimensional mass planes. Additionally, the results are interpreted in terms of 90% confidence-level limits on the dark-matternucleon scattering cross section, as a function of the dark-matter particle mass, for a spin-independent scenario.
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| 18. |
- Abulaiti, Yiming, et al.
(author)
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Search for new phenomena in a lepton plus high jet multiplicity final state the ATLAS experiment using root S=13 TeV proton-proton collision data
- 2017
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In: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :9
-
Journal article (peer-reviewed)abstract
- A search for new phenomena in final states characterized by high jet multiplicity, an isolated lepton ( electron or muon) and either zero or at least three b-tagged jets is presented. The search uses 36.1 fb(-1) of root s = 13TeV proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider in 2015 and 2016. The dominant sources of background are estimated using parameterized extrapolations, based on observables at medium jet multiplicity, to predict the b-tagged jet multiplicity distribution at the higher jet multiplicities used in the search. No significant excess over the Standard Model expectation is observed and 95% confidence-level limits are extracted constraining four simplified models of R-parity-violating supersymmetry that feature either gluino or top-squark pair production. The exclusion limits reach as high as 2.1TeV in gluino mass and 1.2TeV in top-squark mass in the models considered. In addition, an upper limit is set on the cross-section for Standard Model t (t) over bart (t) over bar production of 60 fb (6.5 x the Standard Model prediction) at 95% confidence level. Finally, model-independent limits are set on the contribution from new phenomena to the signal-region yields.
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| 19. |
- Abulaiti, Yiming, et al.
(author)
-
Search for new phenomena with large jet multiplicities and missing transverse momentum using large-radius jets and flavour-tagging at ATLAS in 13 TeV pp collisions
- 2017
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In: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :12
-
Journal article (peer-reviewed)abstract
- A search is presented for particles that decay producing a large jet multiplicity and invisible particles. The event selection applies a veto on the presence of isolated electrons or muons and additional requirements on the number of b-tagged jets and the scalar sum of masses of large-radius jets. Having explored the full ATLAS 2015-2016 dataset of LHC proton-proton collisions at root s = 13 TeV, which corresponds to 36.1 fb(-1) of integrated luminosity, no evidence is found for physics beyond the Standard Model. The results are interpreted in the context of simplified models inspired by R-parity-conserving and R-parity-violating supersymmetry, where gluinos are pair-produced. More generic models within the phenomenological minimal supersymmetric Standard Model are also considered.
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| 20. |
- Frandsen, K. E. H., et al.
(author)
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The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases
- 2016
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In: Nature Chemical Biology. - : Springer Science and Business Media LLC. - 1552-4450 .- 1552-4469. ; 12:4, s. 298-
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Journal article (peer-reviewed)abstract
- Lytic polysaccharide monooxygenases (LPMOs) are copper-containing enzymes that oxidatively break down recalcitrant polysaccharides such as cellulose and chitin. Since their discovery, LPMOs have become integral factors in the industrial utilization of biomass, especially in the sustainable generation of cellulosic bioethanol. We report here a structural determination of an LPMO-oligosaccharide complex, yielding detailed insights into the mechanism of action of these enzymes. Using a combination of structure and electron paramagnetic resonance spectroscopy, we reveal the means by which LPMOs interact with saccharide substrates. We further uncover electronic and structural features of the enzyme active site, showing how LPMOs orchestrate the reaction of oxygen with polysaccharide chains.
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