| 11. |
- Munoz-Gil, G., et al.
(författare)
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Objective comparison of methods to decode anomalous diffusion
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Deviations from Brownian motion leading to anomalous diffusion are found in transport dynamics from quantum physics to life sciences. The characterization of anomalous diffusion from the measurement of an individual trajectory is a challenging task, which traditionally relies on calculating the trajectory mean squared displacement. However, this approach breaks down for cases of practical interest, e.g., short or noisy trajectories, heterogeneous behaviour, or non-ergodic processes. Recently, several new approaches have been proposed, mostly building on the ongoing machine-learning revolution. To perform an objective comparison of methods, we gathered the community and organized an open competition, the Anomalous Diffusion challenge (AnDi). Participating teams applied their algorithms to a commonly-defined dataset including diverse conditions. Although no single method performed best across all scenarios, machine-learning-based approaches achieved superior performance for all tasks. The discussion of the challenge results provides practical advice for users and a benchmark for developers. Deviations from Brownian motion leading to anomalous diffusion are ubiquitously found in transport dynamics but often difficult to characterize. Here the authors compare approaches for single trajectory analysis through an open competition, showing that machine learning methods outperform classical approaches.
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| 12. |
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| 13. |
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| 14. |
- Requena-Mendez, A, et al.
(författare)
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High Prevalence of Strongyloidiasis in Spain: A Hospital-Based Study
- 2020
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Ingår i: Pathogens (Basel, Switzerland). - : MDPI AG. - 2076-0817. ; 9:2
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Strongyloidiasis is a prevailing helminth infection ubiquitous in tropical and subtropical areas, however, seroprevalence data are scarce in migrant populations, particularly for those coming for Asia. Methods: This study aims at evaluating the prevalence of S. stercoralis at the hospital level in migrant populations or long term travellers being attended in out-patient and in-patient units as part of a systematic screening implemented in six Spanish hospitals. A cross-sectional study was conducted and systematic screening for S. stercoralis infection using serological tests was offered to all eligible participants. Results: The overall seroprevalence of S. stercoralis was 9.04% (95%CI 7.76–10.31). The seroprevalence of people with a risk of infection acquired in Africa and Latin America was 9.35% (95%CI 7.01–11.69), 9.22% (7.5–10.93), respectively. The number of individuals coming from Asian countries was significantly smaller and the overall prevalence in these countries was 2.9% (95%CI −0.3–6.2). The seroprevalence in units attending potentially immunosuppressed patients was significantly lower (5.64%) compared with other units of the hospital (10.20%) or Tropical diseases units (13.33%) (p < 0.001). Conclusions: We report a hospital-based strongyloidiasis seroprevalence of almost 10% in a mobile population coming from endemic areas suggesting the need of implementing strongyloidiasis screening in hospitalized patients coming from endemic areas, particularly if they are at risk of immunosuppression.
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| 15. |
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| 16. |
- Ao, Y., et al.
(författare)
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The thermal state of molecular clouds in the Galactic center: evidence for non-photon-driven heating
- 2014
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 9:S303, s. 89-91
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Tidskriftsartikel (refereegranskat)abstract
- We have used the Atacama Pathfinder Experiment (APEX) 12 m telescope at 218 GHz to observe molecular clouds simultaneously in the J_KA,Kc=3_03→2_02,3_22→2_21,and 3_21→2_20 transitions of para-H2CO to determine kinetic temperatures of the dense gas in the central molecular zone of the Galaxy. Gas kinetic temperatures for individual molecular clouds range from 55 to 125 K or even higher. The molecular clouds at high temperatures may be heated by turbulent dissipation and/or cosmic-rays
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| 17. |
- Ao, Y., et al.
(författare)
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The thermal state of molecular clouds in the Galactic center: evidence for non-photon-driven heating
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 550
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Tidskriftsartikel (refereegranskat)abstract
- We used the Atacama Pathfinder Experiment (APEX) 12 m telescope to observe the J(KAKc) = 3(03) -> 2(02), 3(22) -> 2(21), and 3(21) -> 2(20) transitions of para-H2CO at 218 GHz simultaneously to determine kinetic temperatures of the dense gas in the central molecular zone (CMZ) of our Galaxy. The map extends over approximately 40' x 8' (similar to 100 x 20 pc(2)) along the Galactic plane with a linear resolution of 1.2 pc. The strongest of the three lines, the H2CO (3(03) -> 2(02)) transition, is found to be widespread, and its emission shows a spatial distribution similar to ammonia. The relative abundance of para-H2CO is 0.5 - 1.2 x 10(-9), which is consistent with results from lower frequency H2CO absorption lines. Derived gas kinetic temperatures for individual molecular clouds range from 50K to values in excess of 100 K. While a systematic trend toward (decreasing) kinetic temperature versus (increasing) angular distance from the Galactic center (GC) is not found, the clouds with highest temperature (T-kin > 100 K) are all located near the nucleus. For the molecular gas outside the dense clouds, the average kinetic temperature is 65 +/- 10 K. The high temperatures of molecular clouds on large scales in the GC region may be driven by turbulent energy dissipation and / or cosmic-rays instead of photons. Such a non-photon-driven thermal state of the molecular gas provides an excellent template for the more distant vigorous starbursts found in ultraluminous infrared galaxies (ULIRGs).
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| 18. |
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| 19. |
- Chilunga, FP, et al.
(författare)
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Genome-wide DNA methylation analysis on C-reactive protein among Ghanaians suggests molecular links to the emerging risk of cardiovascular diseases
- 2021
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Ingår i: NPJ genomic medicine. - : Springer Science and Business Media LLC. - 2056-7944. ; 6:1, s. 46-
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Tidskriftsartikel (refereegranskat)abstract
- Molecular mechanisms at the intersection of inflammation and cardiovascular diseases (CVD) among Africans are still unknown. We performed an epigenome-wide association study to identify loci associated with serum C-reactive protein (marker of inflammation) among Ghanaians and further assessed whether differentially methylated positions (DMPs) were linked to CVD in previous reports, or to estimated CVD risk in the same population. We used the Illumina Infinium® HumanMethylation450 BeadChip to obtain DNAm profiles of blood samples in 589 Ghanaians from the RODAM study (without acute infections, not taking anti-inflammatory medications, CRP levels < 40 mg/L). We then used linear models to identify DMPs associated with CRP concentrations. Post-hoc, we evaluated associations of identified DMPs with elevated CVD risk estimated via ASCVD risk score. We also performed subset analyses at CRP levels ≤10 mg/L and replication analyses on candidate probes. Finally, we assessed for biological relevance of our findings in public databases. We subsequently identified 14 novel DMPs associated with CRP. In post-hoc evaluations, we found that DMPs in PC, BTG4 and PADI1 showed trends of associations with estimated CVD risk, we identified a separate DMP in MORC2 that was associated with CRP levels ≤10 mg/L, and we successfully replicated 65 (24%) of previously reported DMPs. All DMPs with gene annotations (13) were biologically linked to inflammation or CVD traits. We have identified epigenetic loci that may play a role in the intersection between inflammation and CVD among Ghanaians. Further studies among other Africans are needed to confirm our findings.
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| 20. |
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