| 11. |
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| 12. |
- Mönnich, M., et al.
(författare)
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CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium
- 2018
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Ingår i: Cell Reports. - : Elsevier. - 2211-1247. ; 22:10, s. 2601-2614
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Tidskriftsartikel (refereegranskat)abstract
- The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material. During formation of primary cilia, the mother centriole transforms into a basal body that templates the ciliary axoneme. Ciliogenesis depends on mother centriole-specific distal appendages, whereas the role of subdistal appendages in ciliary function is unclear. Here, we identify CEP128 as a centriole subdistal appendage protein required for regulating ciliary signaling. Loss of CEP128 did not grossly affect centrosomal or ciliary structure but caused impaired transforming growth factor-β/bone morphogenetic protein (TGF-β/BMP) signaling in zebrafish and at the primary cilium in cultured mammalian cells. This phenotype is likely the result of defective vesicle trafficking at the cilium as ciliary localization of RAB11 was impaired upon loss of CEP128, and quantitative phosphoproteomics revealed that CEP128 loss affects TGF-β1-induced phosphorylation of multiple proteins that regulate cilium-associated vesicle trafficking. Mönnich et al. show that CEP128 localizes to the subdistal appendages of the mother centriole and basal body of the primary cilium. CEP128 regulates vesicular trafficking and targeting of RAB11 to the primary cilium. CEP128 loss leads to impaired TGF-β/BMP signaling, which, in zebrafish, is associated with defective organ development.
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| 13. |
- Rogowski, Rafal Z., et al.
(författare)
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Solution Processing of Semiconducting Organic Molecules for Tailored Charge Transport Properties
- 2011
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Ingår i: The Journal of Physical Chemistry C. - : American Chemical Society. - 1932-7447 .- 1932-7455. ; 115:23, s. 11758-11762
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Tidskriftsartikel (refereegranskat)abstract
- We studied the charge transport characteristics of the organic semiconductor 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-PEN) deposited by dip-coating of a solution in an azeotropic solvent mixture. Arrays of crystalline ribbons were obtained with a morphology controllable by variation of the coating speed U. The charge carrier mobility mu, exhibited a systematic and reproducible dependence on the coating speed U and maximum values as high as mu approximate to 1.0 cm(2)/(V s).
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| 14. |
- Zalesny, J., et al.
(författare)
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Mechanical analogy of the nonlinear dynamics of a driven unstable mode near marginal stability
- 2009
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Ingår i: Physics of Plasmas. - : AIP Publishing. - 1089-7674 .- 1070-664X. ; 16:2, s. 022110-
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Tidskriftsartikel (refereegranskat)abstract
- The universal integrodifferential model equation derived by Berk [Phys. Rev. Lett. 76, 1256 (1996)] for studying the nonlinear evolution of unstable modes driven by kinetic wave particle resonances near the instability threshold is reduced to a differential equation and next as a further simplification to a nonlinear oscillator equation. This mechanical analogy properly reproduces most of the essential physics of the system and allows an understanding of the qualitative features of the theory of Berk.
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