11. |
- Sehgal, B. R., et al.
(författare)
-
Characterization of heat transfer processes in a melt pool convection and vessel-creep experiment
- 2002
-
Ingår i: Nuclear Engineering and Design. - 0029-5493 .- 1872-759X. ; 211:2-3, s. 173-187
-
Tidskriftsartikel (refereegranskat)abstract
- The results of an integral experiment on melt pool convection and vessel-creep deformation are presented and analyzed. The experiment is performed on a test facility, named Failure Of REactor VEssel Retention (FOREVER). The facility employs a 1/10-scaled 15Mo3-(German)-steel vessel of 400-mm diameter, 15-mm wall thickness and 750-mm height. A high-temperature ( similar or equal to1300 degreesC) oxide melt is prepared in a SiC-crucible placed in a 50 kW induction furnace and is. then, poured into the 1/10th scale vessel. A MoSi2 50 kW electric heater is employed in the melt pool to heat and maintain its temperature at 1200 degreesC, The vessel is pressurized with argon at the desired pressure. In the FOREVER/Cl experiment. the vessel wall, maintained at about 900 degreesC and pressurized to 26 bars. was subjected to creep deformation in a 24-h non-stop test. The FOREVER/Cl test is the first integral experiment, in which a decay-heated oxidic naturally-convecting melt pool was maintained in long-term contact with the hemispherical lower head of a pressurized. creeping. steel vessel. A sizeable database was obtained on melt pool temperatures. melt pool energy split, heat transfer rates. heat nux distribution on the melt (crust)-vessel contact surface, vessel temperatures and, in particular the vessel wall creep rate as a function of time. The paper provides information on the FOREVER/Cl measured thermal characteristics and analysis of the observed thermal behavior, The coupled nature of thermal and mechanical processes, as well as the effect of other system conditions (such as depressurization) on the melt pool and vessel temperature responses are analyzed.
|
|
12. |
- Soukup, Ondrej, et al.
(författare)
-
Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors - potential crosstalk of cholinergic mechanisms during pharmacological treatment.
- 2017
-
Ingår i: Current neuropharmacology. - 1875-6190. ; 15:4, s. 637-653
-
Tidskriftsartikel (refereegranskat)abstract
- Pharmaceuticals with targets in the cholinergic transmission have been used for decades and are still fundamental treatments in many diseases and conditions today. Both the transmission and the effects of the somatomotoric and the parasympathetic nervous systems may be targeted by such treatments. Irrespective of the knowledge that the effects of neuronal signalling in the nervous systems may include a number of different receptor subtypes of both the nicotinic and the muscarinic receptors, this complexity is generally overlooked when assessing the mechanisms of action of pharmaceuticals. Presently, the life cycle of acetylcholine, muscarinic receptors and their effects are reviewed in the major organ systems of the body. Neuronal and non-neuronal sources of acetylcholine are elucidated. Examples of pharmaceuticals, in particular cholinesterase inhibitors, affecting these systems are discussed. The review focuses on salivary glands, the respiratory tract and the lower urinary tract, since the complexity of the interplay of different muscarinic receptor subtypes is of significance for physiological, pharmacological and toxicological effects in these organs.
|
|