| 11. |
- Eberhard, Jonas, et al.
(författare)
-
Prolactin level during 5 years of risperidone treatment in patients with psychotic disorders
- 2007
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 115:4, s. 268-276
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate prolactin levels and related side effects in 128 men and 90 women initially treated with risperidone. Method: Patients initially treated with risperidone were followed over 5 years, during which 45% were switched to other antipsychotic drugs. Results: Initially, prolactin levels were fivefold the norm in women, and threefold in men. Diagnosis did not affect the prolactin level if adjustment for sex, current age, and age at onset of psychosis was applied. Prolactin levels did not correlate significantly neither with any Positive and Negative Symptom Scale item or subscale, nor with side effects. Drugs other than risperidone were not associated with high prolactin levels. For patients on continuous monotherapy risperidone treatment, there was a marked linear reduction of prolactin level over all 5 years. Conclusion: Risperidone induces a higher prolactin elevation than other atypical antipsychotics, but the effect adapts over time. Prolactin was not associated with expected side effects (e.g. sexual, mental, or weight gain).
|
|
| 12. |
|
|
| 13. |
- Alsén, Margot, et al.
(författare)
-
Medicine self-poisoning and the sources of the drugs in Lund, Sweden
- 1994
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 1600-0447 .- 0001-690X. ; 89:4, s. 255-261
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to investigate the prevalence of toxic agents in attempted and completed suicides. The purpose was also to explore the sources of the drugs taken by suicide attempters. Verbal information on drug intake was collected from 280 suicide attempters during 1987-1990 in the Lund-Orup catchment area. Information on the sources of the drugs was collected from 143 of these attempters. The study also includes toxicological screening from 73 fatal poisonings in southern Sweden during 1989. According to verbal information, the most common drugs used by suicide attempters were benzodiazepines (51%), analgesics (29%) and antidepressants (20%). In suicide attempters, diazepam and levomepromazine were reported more than expected from prescription data. Toxicological screenings of fatal poisonings showed that benzodiazepines were most common (55%), followed by analgesics (38%), mainly propoxyphene (29%) and antidepressants (30%), mainly amitriptyline (22%). Amitriptyline and diazepam were more commonly detected in completed suicides than expected from prescription data. The most common sources of drugs to attempted suicides were physicians, and especially psychiatrists. We therefore conclude that continuous information to physicians on drug overdose is important, and it is also important to introduce alternative strategies to prevent suicidal behaviour.
|
|
| 14. |
|
|
| 15. |
- Brådvik, Louise, et al.
(författare)
-
Late mortality in severe depression
- 2001
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 1600-0447 .- 0001-690X. ; 103:2, s. 111-116
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess late mortality among psychiatric in-patients with severe depression/melancholia.METHOD: 1,206 in-patients rated at discharge on a multidimensional diagnostic schedule had received the diagnosis severe depression/ melancholia between 1956 and 1969. A first follow-up was made in 1984. The present follow-up constitutes 675 survivors 15-42 years after the first admission. They were followed-up by means of the general population register and local parish registers to January 1st 1998.RESULTS: At this second follow-up another 279 patients were deceased, standardized mortality ratio 1.3, indicating a continuous increased mortality late in the course of depression. Eleven suicides (4%) were included, eight men and three women, which was less than the 22% found in the first investigation. Male patients showed a higher suicide rate than female patients late in the course.CONCLUSION: The general mortality and suicide rate remain increased late in the course.
|
|
| 16. |
- Brådvik, Louise, et al.
(författare)
-
Long-term suicide risk of depression in the Lundby cohort 1947-1997 - severity and gender.
- 2008
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 1600-0447 .- 0001-690X. ; 117:3, s. 185-191
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The long-term suicide risk of depression was evaluated in a community sample by severity and gender. Method: The Lundby study is a prospective, longitudinal cohort study on a population consisting of 3563 subjects. In 1947-1997 medium or severe depression according to the Lundby diagnostic system were registered in 503 subjects. The same subjects were also diagnosed according to DSM-IV showing major depressive disorder (MDD) in 293 and depressive disorder not otherwise specified (DDNOS) in 131 subjects. Results: The overall long-term suicide risk varied from 5.6% to 6.8%. The long-term suicide risk was 3.1% for medium and 11.4% for severe 'Lundby depression', 3.7% for medium and 13.8% for severe MDD + DDNOS, 3.1% for medium and 13.7% for severe MDD. Severity and male sex were risk factors for suicide. Conclusion: Males with a severe depression showed a high long-term risk for suicide, around 20%.
|
|
| 17. |
- Brådvik, Louise, et al.
(författare)
-
Seasonal distribution of suicide in alcoholism.
- 2002
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 1600-0447 .- 0001-690X. ; 106:4, s. 299-302
-
Tidskriftsartikel (refereegranskat)abstract
- Brådvik L, Berglund M. Seasonal distribution of suicide in alcoholism. Acta Psychiatr Scand 2002: 106: 299-302. Copyright Blackwell Munksgaard 2002. Objective: To investigate the seasonal distribution of suicide in alcohol dependence and to make a comparison with unnatural death in alcoholism and suicide in other diagnostic groups. Method: Multiaxial ratings of all patients admitted to the Department of Psychiatry in Lund enabled the selection of patients with alcohol dependence (n=1312) during 1949-1969. When followed up to 1997 a total of 102 (99 men) alcoholic patients had taken their own life. Reference groups were patients with severe depression and autopsy cases with other diagnoses. Results: The alcoholic patients showed a peak during the second quarter of the year (34%, P < 0.05). Other diagnostic groups of suicide and unnatural death in alcoholism did not show any overrepresentation in the spring. Conclusion: Male alcoholics showed a spring peak of suicide as opposed to other diagnostic groups.
|
|
| 18. |
- Carlsson, Rickard, et al.
(författare)
-
Neuropsychological functions predict 1-and 3-year outcome in first-episode psychosis
- 2006
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 1600-0447 .- 0001-690X. ; 113:2, s. 102-111
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To examine neuropsychological performance as a possible predictor of course and outcome in first-episode psychotic (FEP) patients. Method: A group of consecutive FEP patients (n = 120) tested with Wechsler Adult Intelligence Scales-Revised (WAIS-R) at baseline was compared with a healthy group (n = 30) matched for age, education and gender. Relationship between WAIS-R and both Brief Psychiatric Rating Scale and Global Assessment of Function (GAF) ratings were studied at baseline and at 1- and 3-year follow-ups. Results: The performance of FEP patients was significantly lower (P < 0.001) than that of healthy comparison subjects on all WAIS-R subtests except for Information and Comprehension. The WAIS-R scores of patients with schizophrenia syndromes (DSM-IV) were lower than those of patients with non-schizophrenia syndromes on Block Design. Low WAIS-R Full-Scale IQ scores in FEP patients predicted the presence of negative symptoms at 1-year follow-up and of low GAF ratings at 3-year follow-up. Conclusion: Neurocognitive performance at admission appears to predict various aspects of functional outcome in FEP.
|
|
| 19. |
|
|
| 20. |
- Eklund, Mona, et al.
(författare)
-
Relationships between characteristics of the ward atmosphere and treatment outcome in a psychiatric day-care unit based on occupational therapy
- 1997
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 1600-0447 .- 0001-690X. ; 95:4, s. 329-335
-
Tidskriftsartikel (refereegranskat)abstract
- The relationships between characteristics of the ward atmosphere and treatment outcome in a psychiatric day-care unit were investigated. The treatment programme was based on occupational group therapy and included long-term mentally ill patients, equally distributed with regard to psychosis and non-psychosis diagnoses. The ward atmosphere was rated on the Community-Oriented Programs Environment Scale (COPES), and outcome variables concerned symptoms, global mental health, quality of life, and functioning in daily life. The COPES ratings were re-coded in order to control for the fact that different levels of ward atmosphere factors are recommended for psychotic and non-psychotic patients. The results revealed that an optimal initial level of anger and aggression in treatment was significantly associated with improvement in global mental health and functioning in everyday life. Initial optimal levels of staff control and practical orientation were significantly associated with improvement in psychiatric symptoms. The characteristics of the ward atmosphere at the end of the treatment period were significantly correlated with various aspects of functioning in daily life. The study demonstrated associations with outcome variables not previously linked with ward atmosphere characteristics, e.g. functioning in daily life and quality of life.
|
|
