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Träfflista för sökning "L773:1751 7176 OR L773:1524 6175 srt2:(2015-2019)"

Sökning: L773:1751 7176 OR L773:1524 6175 > (2015-2019)

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  • Wijkman, Magnus, et al. (författare)
  • Predictors and correlates of systolic blood pressure reduction with liraglutide treatment in patients with type 2 diabetes
  • 2019
  • Ingår i: Journal of Clinical Hypertension. - : Wiley. - 1751-7176 .- 1524-6175. ; 21:1, s. 105-115
  • Tidskriftsartikel (refereegranskat)abstract
    • Liraglutide is associated with blood pressure reduction in patients with type 2 diabetes. However, it is not known whether this blood pressure reduction can be predicted prior to treatment initiation, and to what extent it correlates with weight loss and with improved glycemic control during follow-up. We analyzed data from a double-blind, placebo-controlled trial, in which 124 insulin-treated patients with type 2 diabetes were randomized to liraglutide or placebo. We evaluated various baseline variables as potential predictors of systolic blood pressure (SBP) reduction, and evaluated whether changes in SBP correlated with weight loss and with improved glycemic control. A greater reduction in SBP among liraglutide-treated patients was predicted by higher baseline values of SBP (P < 0.0001) and diastolic blood pressure (P = 0.012), and by lower baseline values of mean glucose measured by continuous glucose monitoring (CGM; P = 0.044), and serum fasting C-peptide (P = 0.015). The regression coefficients differed significantly between the liraglutide group and the placebo group only for diastolic blood pressure (P = 0.037) and mean CGM (P = 0.021). During the trial period, SBP reduction correlated directly with change in body weight and BMI, but not with change in HbA1c. We conclude that patients with lower mean CGM values at baseline responded to liraglutide with a larger reduction in SBP, and that improved HbA1c during follow-up was not associated with reductions of SBP. Our data suggest that some patients with type 2 diabetes may benefit from liraglutide in terms of weight and SBP reduction.
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15.
  • Wijkman, Magnus, 1978-, et al. (författare)
  • The exaggerated blood pressure response to exercise in the sub-acute phase after stroke is not affected by aerobic exercise.
  • 2018
  • Ingår i: The Journal of Clinical Hypertension. - Hoboken, United States : Le Jacq Communications, Inc.. - 1524-6175 .- 1751-7176. ; 20, s. 56-64
  • Tidskriftsartikel (refereegranskat)abstract
    • The prevalence of an exaggerated exercise blood pressure (BP) response is unknown in patients with subacute stroke, and it is not known whether an aerobic exercise program modulates this response. The authors randomized 53 patients (27 women) with subacute stroke to 12 weeks of twice-weekly aerobic exercise (n = 29) or to usual care without scheduled physical exercise (n = 24). At baseline, 66% of the patients exhibited an exaggerated exercise BP response (peak systolic BP ≥210 mm Hg in men and ≥190 mm Hg in women) during a symptom-limited ergometer exercise test. At follow-up, patients who had been randomized to the exercise program achieved higher peak work rate, but peak systolic BP remained unaltered. Among patients with a recent stroke, it was common to have an exaggerated systolic BP response during exercise. This response was not altered by participation in a 12-week program of aerobic exercise.
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