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Sökning: WFRF:(Appelgren M.) > (2020-2024)

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11.
  • Appelgren, J., et al. (författare)
  • Disc population synthesis : Decrease in the solid mass reservoir through pebble drift
  • 2023
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 673
  • Tidskriftsartikel (refereegranskat)abstract
    • Surveys of star-forming regions reveal that the dust mass of protoplanetary discs decreases by several orders of magnitude on timescales of a few million years. This decrease in the mass budget of solids is likely due to the radial drift of millimetre (mm) sized solids, called pebbles, induced by gas drag. However, quantifying the evolution of this dust component in young stellar clusters is difficult due to the inherent large spread in stellar masses and formation times. Therefore, we aim to model the collective evolution of a cluster to investigate the effectiveness of radial drift in clearing the discs of mm-sized particles. We use a protoplanetary disc model that provides a numerical solution for the disc formation, as well as the viscous evolution and photoevaporative clearing of the gas component, while also including the drift of particles limited in size by fragmentation. We find that discs are born with dust masses between 50 M· and 1000 M·, for stars with masses, respectively, between 0.1 M· and 1 M·. The majority of this initial dust reservoir is typically lost through drift before photoevaporation opens a gap in the gas disc for models both with and without strong X-ray-driven mass-loss rates. We conclude that the decrease in time of the mass locked in fragmentation-limited pebbles is consistent with the evolution of dust masses and ages inferred from nearby star-forming regions, when assuming viscous evolution rates corresponding to mean gas disc lifetimes between 3 Myr and 8 Myr.
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12.
  • Appelgren, M., et al. (författare)
  • Patient-reported outcomes one year after positive sentinel lymph node biopsy with or without axillary lymph node dissection in the randomized SENOMAC trial
  • 2022
  • Ingår i: Breast. - : Elsevier BV. - 0960-9776 .- 1532-3080. ; 63, s. 16-23
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: This report evaluates whether health related quality of life (HRQoL) and patient-reported arm morbidity one year after axillary surgery are affected by the omission of axillary lymph node dissection (ALND). Methods: The ongoing international non-inferiority SENOMAC trial randomizes clinically node-negative breast cancer patients (T1-T3) with 1-2 sentinel lymph node (SLN) macrometastases to completion ALND or no further axillary surgery. For this analysis, the first 1181 patients enrolled in Sweden and Denmark between March 2015, and June 2019, were eligible. Data extraction from the trial database was on November 2020. This report covers the secondary outcomes of the SENOMAC trial: HRQoL and patient-reported arm morbidity. The EORTC QLQC30, EORTC QLQ-BR23 and Lymph-ICF questionnaires were completed in the early postoperative phase and at one-year follow-up. Adjusted one-year mean scores and mean differences between the groups are presented corrected for multiple testing.
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  • Resultat 11-12 av 12

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