| 11. |
- Bader, Thomas K., 1980-, et al.
(författare)
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Experimental characterization of the global and local behavior of multi-dowel LVL-connections under complex loading
- 2016
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Ingår i: Materials and Structures. - : Springer Science and Business Media LLC. - 1359-5997 .- 1871-6873. ; 49:6, s. 2407-2424
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Tidskriftsartikel (refereegranskat)abstract
- The thorough experimental characterization of a dowel-type connection under various combinations of bending moments and normal forces is presented in this study. Double-shear steel-to-timber connections with 12 and 20 mm steel dowels were tested in a 4-point bending test set-up. The load, between the connected steel and wood beams, was transferred by the dowels themselves and also via an additional (passive) contact device, which introduced an eccentric normal force in the timber beam. The behavior of the connections was studied at the global scale of the connection and at the local scale of the individual dowels. A non-contact deformation measurement system was used to assess the changes of the location of the center of relative rotation over the entire loading. At the same time, the head deformations of the individual dowels could be measured, giving a direct indication about the force distribution among the dowels. Due to reinforcement, connections behaved distinctly ductile with a global relative rotation of up to 3°. Pre-stressing of the contact device by a force of 40 kN yielded an even stiffer behavior. For the particular configurations tested herein, the center of rotation was found to be close to the vertical axis of symmetry of the joint and close to the top row of the dowels. Moreover, the superimposed vertical shift of the center of relative rotation in case of a delayed normal force could be quantified. © 2015 RILEM
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| 12. |
- Bader, Thomas K., et al.
(författare)
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Integrative experimental characterization and engineering modeling of single-dowel connections in LVL
- 2016
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Ingår i: Construction and Building Materials. - : Elsevier BV. - 0950-0618 .- 1879-0526. ; 107, s. 235-246
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Tidskriftsartikel (refereegranskat)abstract
- In order to be able to realistically and consistently elucidate and subsequently simulate the load displacement behavior of single-dowel connections, the material behavior of the individual components, namely steel dowels and wood, needs to be investigated. The behavior of slotted-in, single-dowel steel-to-laminated veneer lumber (LVL) connections with dowel diameters of 12 and 20 mm is thoroughly discussed here in relation to steel dowel and LVL properties. In addition to connection tests at different load-to-grain directions of 0, 45 and 90, the corresponding embedment behavior of LVL was tested up to dowel displacements of three times the dowel diameter. The material behavior of steel dowels was studied by means of tensile and 3-point bending tests and accompanying finite element simulations. A pronounced nonlinear behavior of the single-dowel connections was observed for all load-to-grain directions. In case of loading perpendicular to the grain, a significant hardening behavior was obvious. Due to the anisotropic material properties of wood, enforcing a loading direction of 45 to the grain resulted in an additional force perpendicular to the load direction which was quantified in a novel biaxial test setup. Thus, a comprehensive and consistent database over different scales of observations of dowel connections could be established, which subsequently was exploited by means of engineering modeling. The comparison of experimental and numerical data illustrates the potential of the engineering modeling approach to overcome drawbacks of current design regulations, which are unable to appropriately predict stiffness properties of dowel connections. Moreover, the quasi-elastic limit of dowel connections was calculated and discussed by means of the model. (c) 2016 Elsevier Ltd. All rights reserved.
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| 13. |
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| 14. |
- Hafrén, Jonas, et al.
(författare)
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Optical properties of thermomechanical pulp (TMP) obtained from sulfite-pretreated Norway spruce with focus on two-photon spectral imaging (TPSI)
- 2012
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Ingår i: Holzforschung. - : Walter de Gruyter GmbH. - 0018-3830 .- 1437-434X. ; 66:7, s. 817-824
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Tidskriftsartikel (refereegranskat)abstract
- Chips of Norway spruce have been impregnated with Na2SO3 and refined at two specific energy consumptions levels at full mill scale. The optical properties of thermomechanical pulps (TMPs) obtained were analyzed in terms of brightness, light scattering, opacity, and autofluorescence by spectral imaging. Even at low sulfite dosage (0.24% sulfite by dry weight) light absorption was reduced, and the brightness was elevated, and a clear dose-response effect was observed. Two-photon spectral imaging (TPSI) showed that sulfonation, impregnation, and refining affect the fluorescence properties differently. Compared to native wood, both processed wood chips and pulp fibers revealed blue-shifted fluorescence maxima, a characteristic of shortened conjugated systems. Two subpopulations of fibers with different optical properties were observed, and the fluorescence of one fiber population was red shifted.
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| 15. |
- Lankester, Arjan C, et al.
(författare)
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Hematopoietic cell transplantation in severe combined immunodeficiency: The SCETIDE 2006-2014 European cohort.
- 2022
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Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 149:5
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Tidskriftsartikel (refereegranskat)abstract
- Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), a group of monogenic immune disorders with an otherwise fatal outcome.We performed a comprehensive multicenter analysis of genotype-specific HSCT outcome, including detailed analysis of immune reconstitution (IR) and the predictive value for clinical outcome.HSCT outcome was studied in 338 patients with genetically confirmed SCID who underwent transplantation in 2006-2014 and who were registered in the SCETIDE registry. In a representative subgroup of 152 patients, data on IR and long-term clinical outcome were analyzed.Two-year OS was similar with matched family and unrelated donors and better than mismatched donor HSCT (P<.001). The 2-year event-free survival (EFS) was similar in matched and mismatched unrelated donor and less favorable in mismatched related donor (MMRD) HSCT (P< .001). Genetic subgroups did not differ in 2-year OS (P= .1) and EFS (P=.073). In multivariate analysis, pretransplantation infections and use of MMRDs were associated with less favorable OS and EFS. With a median follow-up of 6.2 years (range, 2.0-11.8 years), 73 of 152 patients in the IR cohort were alive and well without Ig dependency. IL-2 receptor gamma chain/Janus kinase 3/IL-7 receptor-deficient SCID, myeloablative conditioning, matched donor HSCT, and naive CD4 T lymphocytes >0.5×10e3/μL at+1 year were identified as independent predictors of favorable clinical and immunologic outcome.Recent advances in HSCT in SCID patients have resulted in improved OS and EFS in all genotypes and donor types. To achieve a favorable long-term outcome, treatment strategies should aim for optimal naive CD4 T lymphocyte regeneration.
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| 16. |
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