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Sökning: WFRF:(Barcikowska M. J.)

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11.
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12.
  • Sitek, E. J., et al. (författare)
  • A Patient with Posterior Cortical Atrophy Possesses a Novel Mutation in the Presenilin 1 Gene
  • 2013
  • Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting visual association cortex. Most patients diagnosed with posterior cortical atrophy will finally develop a typical Alzheimer's disease. However, there are a variety of neuropathological processes, which could lead towards a clinical presentation of posterior cortical atrophy. Mutations in the presenilin 1 gene, affecting the function of gamma-secretase, are the most common genetic cause of familial, early-onset Alzheimer's disease. Here we present a patient with a clinical diagnosis of posterior cortical atrophy who harbors a novel Presenilin 1 mutation (I211M). In silico analysis predicts that the mutation could influence the interaction between presenilin 1 and presenilin1 enhancer-2 protein, a protein partner within the gamma-secretase complex. These findings along with published literature support the inclusion of posterior cortical atrophy on the Alzheimer's disease spectrum.
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13.
  • Barcikowska, M. J., et al. (författare)
  • Chances in the future summer Mediterranean climate: contribution of teleconnections and local factors
  • 2020
  • Ingår i: Earth System Dynamics. - : Copernicus GmbH. - 2190-4979 .- 2190-4987. ; 11:1, s. 161-181
  • Tidskriftsartikel (refereegranskat)abstract
    • This study analyzes future climate for the Mediterranean region projected with the high-resolution coupled CM2.5 model, which incorporates a new and improved land model (LM3). The simulated climate changes suggest pronounced warming and drying over most of the region. However, the changes are distinctly smaller than those of the CMIP5 multi-model ensemble. In addition, the changes over much of southeast and central Europe indicate very modest warming compared to the CMIP5 projections and also a tendency toward wetter conditions. These differences indicate a possible role of factors such as land surface-atmospheric interactions in these regions. Our analysis also highlights the importance of correctly projecting the magnitude of changes in the summer North Atlantic Oscillation, which has the capacity to partly offset anthropogenic warming and drying over the western and central Mediterranean. Nevertheless, the projections suggest a decreasing influence of local atmospheric dynamics and teleconnections in maintaining the regional temperature and precipitation balance, in particular over arid regions like the eastern and southern Mediterranean, which show a local maximum of warming and drying. The intensification of the heat low in these regions rather suggests an increasing influence of warming land surface on the local surface atmospheric circulation and progressing desertification.
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  • Resultat 11-14 av 14

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