| 11. |
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| 12. |
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| 13. |
- Andersson, LM, et al.
(författare)
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Vibrational wave packet dynamics in NaK : The A (1)Sigma(+) state
- 1999
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Ingår i: Chemical Physics. - 0301-0104 .- 1873-4421. ; 241:1, s. 43-54
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Tidskriftsartikel (refereegranskat)abstract
- A combined experimental and theoretical study of the vibrational wave packet dynamics for the NaK molecule in the A (1)Sigma(+) state is presented. The experiment utilises a 790 nm one-colour femtosecond pump-probe scheme with detection of a previously nor reported dissociation pathway of the 3 (1)Pi(+) state, leading to the Na(3p) + K(4s) product channel. The dissociation is suggested to proceed via either collisionally mediated processes or a molecular cascading process via the 4 (1)Sigma(+) state, which crosses several states correlating to the Na(3p) + K(4s) limit. Time-dependent quantum mechanical calculations are used for studying the dynamics in detail. Simulations are performed both for 790 nm and for 766 nm, to relate also to earlier studies. The previous interpretations of the probe processes are revised. Inclusion of vibrational and rotational temperature effects are shown to be crucial for explaining the shape of the signal and the vibrational period, and leads to excellent agreement with the experiments.
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| 14. |
- Berg, LM, et al.
(författare)
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Fitness and sexual response to population density in Daphnia pulex
- 2001
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Ingår i: FRESHWATER BIOLOGY. - 0046-5070. ; 46:5, s. 667-677
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Tidskriftsartikel (refereegranskat)abstract
- 1. The switch between asexual and sexual reproduction is an important fitness component in cyclically parthenogenetic populations as it is the key to persistence in unstable habitats and because it influences population genetic characteristics such as lin
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| 15. |
- Berg, LM, et al.
(författare)
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Neutral genetic differentiation in an island model with cyclical parthenogenesis
- 2000
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Ingår i: JOURNAL OF EVOLUTIONARY BIOLOGY. - 1010-061X. ; 13:3, s. 488-494
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Tidskriftsartikel (refereegranskat)abstract
- Unusually high levels of genetic differentiation are often observed between populations of Daphnia (Crustacea: Cladocera) and other cladocerans. Selection and departure from migration-mutation-drift equilibrium have been invoked to explain this fact. Howe
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| 16. |
- Berg, LM, et al.
(författare)
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The infinite island model with sex-differentiated gene flow
- 1998
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Ingår i: HEREDITY. - 0018-067X. ; 81, s. 63-68
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Tidskriftsartikel (refereegranskat)abstract
- Identity measures are derived for the infinite island model with separate sexes and sex-differentiated contribution to gene flow. The concept of effective migration rate, m(e), is introduced, which describes the genetically effective flow when sexes migra
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| 17. |
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| 18. |
- Clark, DW, et al.
(författare)
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Associations of autozygosity with a broad range of human phenotypes
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
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Tidskriftsartikel (refereegranskat)abstract
- In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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| 19. |
- Farrell, M, et al.
(författare)
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Increased Prevalence of Rare Copy Number Variants in Treatment-Resistant Psychosis
- 2023
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Ingår i: Schizophrenia bulletin. - : Oxford University Press (OUP). - 1745-1701 .- 0586-7614. ; 49:4, s. 881-892
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIt remains unknown why ~30% of patients with psychotic disorders fail to respond to treatment. Previous genomic investigations of treatment-resistant psychosis have been inconclusive, but some evidence suggests a possible link between rare disease-associated copy number variants (CNVs) and worse clinical outcomes in schizophrenia. Here, we identified schizophrenia-associated CNVs in patients with treatment-resistant psychotic symptoms and then compared the prevalence of these CNVs to previously published schizophrenia cases not selected for treatment resistance.MethodsCNVs were identified using chromosomal microarray (CMA) and whole exome sequencing (WES) in 509 patients with treatment-resistant psychosis (a lack of clinical response to ≥3 adequate antipsychotic medication trials over at least 5 years of psychiatric hospitalization). Prevalence of schizophrenia-associated CNVs in this sample was compared to that in a previously published large schizophrenia cohort study.ResultsIntegrating CMA and WES data, we identified 47 cases (9.2%) with at least one CNV of known or possible neuropsychiatric risk. 4.7% (n = 24) carried a known neurodevelopmental risk CNV. The prevalence of well-replicated schizophrenia-associated CNVs was 4.1%, with duplications of the 16p11.2 and 15q11.2-q13.1 regions, and deletions of the 22q11.2 chromosomal region as the most frequent CNVs. Pairwise loci-based analysis identified duplications of 15q11.2-q13.1 to be independently associated with treatment resistance.ConclusionsThese findings suggest that CNVs may uniquely impact clinical phenotypes beyond increasing risk for schizophrenia and may potentially serve as biological entry points for studying treatment resistance. Further investigation will be necessary to elucidate the spectrum of phenotypic characteristics observed in adult psychiatric patients with disease-associated CNVs.
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| 20. |
- Farrell, M, et al.
(författare)
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Treatment-resistant psychotic symptoms and the 15q11.2 BP1-BP2 (Burnside-Butler) deletion syndrome: case report and review of the literature
- 2020
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 10:1, s. 42-
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Tidskriftsartikel (refereegranskat)abstract
- The 15q11.2 BP1-BP2 (Burnside-Butler) deletion is a rare copy number variant impacting four genes (NIPA1, NIPA2, CYFIP1, and TUBGCP5), and carries increased risks for developmental delay, intellectual disability, and neuropsychiatric disorders (attention-deficit/hyperactivity disorder, autism, and psychosis). In this case report (supported by extensive developmental information and medication history), we present the complex clinical portrait of a 44-year-old woman with 15q11.2 BP1-BP2 deletion syndrome and chronic, treatment-resistant psychotic symptoms who has resided nearly her entire adult life in a long-term state psychiatric institution. Diagnostic and treatment implications are discussed.
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