| 11. |
- Amodu, O. K., et al.
(författare)
-
Association of the sickle cell trait and the ABO blood group with clinical severity of malaria in southwest Nigeria
- 2012
-
Ingår i: Acta Tropica. - : Elsevier BV. - 0001-706X .- 1873-6254. ; 123:2, s. 72-77
-
Tidskriftsartikel (refereegranskat)abstract
- In regions of high Plasmodium falciparum malaria endemicity, certain erythrocyte polymorphisms confer resistance to severe disease. In this study, we evaluate the role of the sickle cell trait (HbS) and ABO blood groups in the clinical manifestations of childhood malaria in Southwest Nigeria. The subjects comprised 3100 children (53% males, median age 39 months), including 1400 children with uncomplicated malaria, 1000 children with asymptomatic malaria and 700 with severe malaria. Haemoglobin (Hb) types were determined using electrophoresis and serum agglutination techniques were used to determine ABO blood groups. Blood group O was the commonest ABO blood group (47.7%) in the study population, the others were A (22.5%), B (25.2%) and AB (4.6%). The frequencies of the HbAS and HbAC were 14.4% and 5.8%, respectively. In regression models adjusting for age, gender, parasite density and blood group, HbAS was associated with a reduced risk of severe malaria OR=0.46 (CI95%: 0.273-0.773). Among severe malaria subjects, HbAS was associated with significantly lower parasite densities. The protective effect of blood group 0 was demonstrated with a decreased risk of severe malaria OR=0.743 (CI95%: 0.566-0.976) after adjusting for age, gender and parasite density and Hb genotype. Blood group B was associated with increased risk of severe malaria OR=1.638 (CI95%: 1.128-2.380) after adjusting for age, gender, packed cell volume, parasite density and Hb genotype. We have confirmed from this large study of Nigerian children the major protective effective of the sickle cell heterozygous state against both cerebral malaria and severe malarial anaemia. We also show that the B blood group is associated with an increased risk of severe malaria. In conclusion, the sickle cell haemoglobin type and ABO groups modulate the risk of severe malaria in Nigerian children.
|
|
| 12. |
|
|
| 13. |
- Boström, R., Eriksson, A.I., Åhlén, L., Blomberg, L., Gustafsson, G., Holback, B., Holmgren, G., Holtet, J., Jansson, S.E., Lindqvist, P.A., Lybekk, B., Mälkki, A., Riihelä, P. and Wahlund, J.E.
(författare)
-
The Rosetta Dual Langmuir Probe Instrument for Measurements of Plasma Density, Temperature and Flow Velocity.
- 2001
-
Ingår i: ESA SP-1165.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 14. |
- Cumnock, J. A., et al.
(författare)
-
Interplanetary magnetic field control of theta aurora development
- 2002
-
Ingår i: Journal of Geophysical Research. - : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202. ; 107:A7
-
Tidskriftsartikel (refereegranskat)abstract
- [1] We ascertain the influence of the B-y component of the interplanetary magnetic field (IMF) on theta aurora evolution. During most cases where a transpolar arc is observed to move across the polar region, and form a theta aurora, there are brief (minutes) southward excursions of IMF B-z, however northward IMF is required prior to theta aurora formation. Observations show that theta aurora can form during strictly northward IMF with its motion consistent with a change in sign of IMF B-y. It is important to note that since transpolar arcs can persist for 20-30 min after the IMF turns southward, errors will occur in assigning instantaneous IMF conditions to snapshots'' of particular auroral patterns. We consider the entire evolution of the theta aurora and the changing IMF conditions. The influence of IMF B-y is best illustrated by examples which occur during steady northward IMF as compared to times when the IMF is northward on average. We show examples, provided by the Polar UV imager, when the IMF is steady northward. For one case, DMSP F13 and F14 provide in situ measurements of precipitating particles, ionospheric plasma flows and ion density. This unique data set enables us to analyze in detail the evolution of a theta aurora, in one case crossing the entire polar region. No sign change in B-z is needed for theta aurora formation.
|
|
| 15. |
- Eriksson, Anders, et al.
(författare)
-
RPC-LAP : The Rosetta Langmuir probe instrument
- 2007
-
Ingår i: Space Science Reviews. - : Springer Science and Business Media LLC. - 0038-6308 .- 1572-9672. ; 128:04-jan, s. 729-744
-
Forskningsöversikt (refereegranskat)abstract
- The Rosetta dual Langmuir probe instrument, LAP, utilizes the multiple powers of a pair of spherical Langmuir probes for measurements of basic plasma parameters with the aim of providing detailed knowledge of the outgassing, ionization, and subsequent plasma processes around the Rosetta target comet. The fundamental plasma properties to be studied are the plasma density, the electron temperature, and the plasma flow velocity. However, study of electric fields up to 8 kHz, plasma density fluctuations, spacecraft potential, integrated UV flux, and dust impacts is also possible. LAP is fully integrated in the Rosetta Plasma Consortium (RPC), the instruments of which together provide a comprehensive characterization of the cometary plasma.
|
|
| 16. |
- Feldstein, Y. I., et al.
(författare)
-
Auroral electrojets and 3D currents in the ionosphere-magnetosphere system
- 2006
-
Ingår i: “Physics of Auroral Phenomena”, Proc. XXIX Annual Seminar, Apatity. - : Kola Science Centre, Russian Academy of Science. ; , s. 25-30
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- There are shortly described results of the analysis of variations in the location and intensity of the auroral electrojets during magnetic storms and substorms using a numerical method for estimating the equivalent ionospheric currents based on data from meridian chains of magnetic observatories. It is shown that the westward electrojet adjoins to the polar electrojet located at cusp latitudes in the dayside sector. The association of electrojets with the field-aligned currents (FACs), namely Region 1 FAC and Region 2 FAC is considered. During intense disturbances a Region 3 FAC (accompanied with diffuse electron precipitation from the plasma sheet boundary layer) with the downward current was identified. The analysis of observational data is summarized in terms of 2D time-latitude distribution of electrojets at ionospheric altitudes. The magnetic field sawtooth variations generated during the storm main and early recovery phases are also discussed. To follow 3D currents in the magnetosphereionosphere system a clarified view of interrelated 3D currents and magnetospheric plasma domains is presented.
|
|
| 17. |
- Feldstein, Y. I., et al.
(författare)
-
Auroral electrojets and boundaries of plasma domains in the magnetosphere during magnetically disturbed intervals
- 2006
-
Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 24:8, s. 2243-2276
-
Tidskriftsartikel (refereegranskat)abstract
- We investigate variations in the location and intensity of the auroral electrojets during magnetic storms and substorms using a numerical method for estimating the equivalent ionospheric currents based on data from meridian chains of magnetic observatories. Special attention was paid to the complex structure of the electrojets and their interrelationship with diffuse and discrete particle precipitation and field-aligned currents in the dusk sector. During magnetospheric substorms the eastward electrojet (EE) location in the evening sector changes with local time from cusp latitudes (Phi similar to 77 degrees) during early afternoon to latitudes of diffuse auroral precipitation (Phi similar to 65 degrees) equatorward of the auroral oval before midnight. During the main phase of an intense magnetic storm the eastward currents in the noon-early evening sector adjoin to the cusp at Phi similar to 65 degrees and in the pre-midnight sector are located at subauroral latitude Phi similar to 57 degrees. The westward electrojet (WE) is located along the auroral oval from evening through night to the morning sector and adjoins to the polar electrojet (PE) located at cusp latitudes in the day-side sector. The integrated values of the eastward (westward) equivalent ionospheric current during the intense substorm are similar to 0.5 MA (similar to 1.5 MA), whereas they are 0.7 MA (3.0 MA) during the storm main phase maximum. The latitudes of auroral particle precipitation in the dusk sector are identical with those of both electrojets. The EE in the evening sector is accompanied by particle precipitation mainly from the Alfven layer but also from the near-Earth part of the central plasma sheet. In the lower-latitude part of the EE the field-aligned currents (FACs) flow into the ionosphere (Region 2 FAC), and at its higher-latitude part the FACs flow out of the ionosphere (Region 1 FAC). During intense disturbances, in addition to the Region 2 FAC and the Region 1 FAC, a Region 3 FAC with the downward current was identified. This FAC is accompanied by diffuse electron precipitation from the plasma sheet boundary layer. Actually, the triple system of FAC is observed in the evening sector and, as a consequence, the WE and the EE overlap. The WE in the evening sector comprises only the high-latitude periphery of the plasma precipitation region and corresponds to the Hall current between the Region 1 FAC and Region 3 FAC. During the September 1998 magnetic storm, two velocity bursts (similar to 2-4 km/s) in the magnetospheric convection were observed at the latitudes of particle precipitation from the central plasma sheet and at subauroral latitudes near the ionospheric trough. These kind of bursts are known as subauroral polarization streams (SAPS). In the evening sector the Alfven layer equatorial boundary for precipitating ions is located more equatorward than that for electrons. This may favour northward electric field generation between these boundaries and may cause high speed westward ions drift visualized as SAPS. Meanwhile, high speed ion drifts cover a wider range of latitudes than the distance between the equatorward boundaries of ions and electrons precipitation. To summarize the results obtained a new scheme of 3-D currents in the magnetosphere-ionosphere system and a clarified view of interrelated 3-D currents and magnetospheric plasma domains are proposed.
|
|
| 18. |
- Ferwerda, Bart, et al.
(författare)
-
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.
- 2009
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:25, s. 10272-10277
-
Tidskriftsartikel (refereegranskat)abstract
- Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic era. Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream of the Toll-like receptor (TLR) 2 and 4 pathways, has been described to provide protection against a broad range of infectious pathogens. We assessed the functional effects of this polymorphism in human experimental endotoxemia, and we demonstrate that individuals bearing the TIRAP 180L allele display an increased, innate immune response to TLR4 and TLR2 ligands, but not to TLR9 stimulation. This phenotype has been related to an increased resistance to infection. However, an overshoot in the release of proinflammatory cytokines by TIRAP 180L homozygous individuals suggests a scenario of balanced evolution. We have also investigated the worldwide distribution of the Ser180Leu polymorphism in 14 populations around the globe to correlate the genetic makeup of TIRAP with the local infectious pressures. Based on the immunological, clinical, and genetic data, we propose that this mutation might have been selected in West Eurasia during the early settlement of this region after the out-of-Africa migration of modern Homo sapiens. This combination of functional and genetic data provides unique insights to our understanding of the pathogenesis of sepsis.
|
|
| 19. |
|
|
| 20. |
- Giha, H. A., et al.
(författare)
-
A malaria serological map indicating the intersection between parasite antigenic diversity and host antibody repertoires
- 2012
-
Ingår i: European Journal of Clinical Microbiology and Infectious Diseases. - : Springer Science and Business Media LLC. - 0934-9723 .- 1435-4373. ; 31:11, s. 3117-3125
-
Tidskriftsartikel (refereegranskat)abstract
- A malaria vaccine targeting Plasmodium falciparum remains a strategic goal for malaria control. If a polyvalent vaccine is to be developed, its subunits would probably be chosen based on immunogenicity (concentration of elicited antibodies) and associations of selected antigens with protection. We propose an additional possible selection criterion for the inclusion of subunit antigens; that is, coordination between elicited antibodies. For the quantitative estimation of this coordination, we developed a malaria serological map (MSM). Construction of the MSM was based on three categories of variables: (i) malaria antigens, (ii) total IgG and IgG subclasses, (iii) different sources of plasma. To validate the MSM, in this study, we used four malaria antigens (AMA1, MSP2-3D7, MSP2-FC27 and Pf332-C231) and re-grouped the plasma samples into five pairs of subsets based on age, gender, residence, HbAS and malaria morbidity in 9 years. The plasma total IgG and IgG subclasses to the test antigens were measured, and the whole material was used for the MSM construction. Most of the variables in the MSM were previously tested and their associations with malaria morbidity are known. The coordination of response to each antigens pair in the MSM was quantified as the correlation rate (CR = overall number of significant correlations/total number of correlations x 100 %). Unexpectedly, the results showed that low CRs were mostly associated with variables linked with malaria protection and the antigen eliciting the least CRs was the one associated with protection. The MSM is, thus, of potential value for vaccine design and understanding of malaria natural immunity.
|
|
