| 11. |
- Lorenzini, R., et al.
(författare)
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Self-organized helical equilibria as a new paradigm for ohmically heated fusion plasmas
- 2009
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Ingår i: Nature Physics. - : Springer Science and Business Media LLC. - 1745-2473 .- 1745-2481. ; 5:8, s. 570-574
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Tidskriftsartikel (refereegranskat)abstract
- In the quest for new energy sources, the research on controlled thermonuclear fusion has been boosted by the start of the construction phase of the International Thermonuclear Experimental Reactor (ITER). ITER is based on the tokamak magnetic configuration, which is the best performing one in terms of energy confinement. Alternative concepts are however actively researched, which in the long term could be considered for a second generation of reactors. Here, we show results concerning one of these configurations, the reversed-field pinch (RFP). By increasing the plasma current, a spontaneous transition to a helical equilibrium occurs, with a change of magnetic topology. Partially conserved magnetic flux surfaces emerge within residual magnetic chaos, resulting in the onset of a transport barrier. This is a structural change and sheds new light on the potential of the RFP as the basis for a low-magnetic-field ohmic fusion reactor.
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| 12. |
- Martin, P., et al.
(författare)
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Overview of RFX-mod results
- 2009
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 49:10, s. 104019-
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Tidskriftsartikel (refereegranskat)abstract
- With the exploration of the MA plasma current regime in up to 0.5 s long discharges, RFX-mod has opened new and very promising perspectives for the reversed field pinch (RFP) magnetic configuration, and has made significant progress in understanding and improving confinement and in controlling plasma stability. A big leap with respect to previous knowledge and expectations on RFP physics and performance has been made by RFX-mod since the last 2006 IAEA Fusion Energy Conference. A new self-organized helical equilibrium has been experimentally achieved ( the Single Helical Axis-SHAx-state), which is the preferred state at high current. Strong core electron transport barriers characterize this regime, with electron temperature gradients comparable to those achieved in tokamaks, and by a factor of 4 improvement in confinement time with respect to the standard RFP. RFX-mod is also providing leading edge results on real-time feedback control of MHD instabilities, of general interest for the fusion community.
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| 13. |
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| 14. |
- Terranova, D., et al.
(författare)
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A 3D approach to equilibrium, stability and transport studies in RFX-mod improved regimes
- 2010
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 52:12, s. 124023-
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Tidskriftsartikel (refereegranskat)abstract
- The full three-dimensional (3D) approach is now becoming an important issue for all magnetic confinement configurations. It is a necessary condition for the stellarator but also the tokamak and the reversed field pinch (RFP) now cannot be completely described in an axisymmetric framework. For the RFP the observation of self-sustained helical configurations with improved plasma performances require a better description in order to assess a new view on this configuration. In this new framework plasma configuration studies for RFX-mod have been considered both with tools developed for the RFP as well as considering codes originally developed for the stellarator and adapted to the RFP. These helical states are reached through a transition to a very low/reversed shear configuration leading to internal electron transport barriers. These states are interrupted by MHD reconnection events and the large Te gradients at the barriers indicate that both current and pressure driven modes are to be considered. Furthermore the typically flat Te profiles in the helical core have raised the issue of the role of electrostatic and electromagnetic turbulence in these reduced chaos regions, so that a stability analysis in the correct 3D geometry is required to address an optimization of the plasma setup. In this viewtheVMECcode proved to be an effectiveway to obtain helical equilibria to be studied in terms of stability and transport with a suite of well tested codes. In this work, the equilibrium reconstruction technique as well as the experimental evidence of 3D effects and their first interpretation in terms of stability and transport are presented using both RFP and stellarator tools.
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| 15. |
- Puiatti, M. E., et al.
(författare)
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Helical equilibria and magnetic structures in the reversed field pinch and analogies to the tokamak and stellarator
- 2009
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 51:12, s. 124031-
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Tidskriftsartikel (refereegranskat)abstract
- The reversed field pinch configuration is characterized by the presence of magnetic structures both in the core and at the edge: in the core, at high plasma current the spontaneous development of a helical structure is accompanied by the appearance of internal electron transport barriers; at the edge strong pressure gradients, identifying an edge transport barrier, are observed too, related to the position of the field reversal surface. The aim of this paper is the experimental characterization of both the internal and edge transport barriers in relation to the magnetic topology, discussing possible analogies and differences with other confinement schemes.
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| 16. |
- Puiatti, M. E., et al.
(författare)
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Internal and external electron transport barriers in the RFX-mod reversed field pinch
- 2011
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 51:7, s. 073038-
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Tidskriftsartikel (refereegranskat)abstract
- An interesting result of magnetic chaos reduction in RFX-mod high current discharges is the development of strong electron transport barriers. An internal heat and particle transport barrier is formed when a bifurcation process changes the magnetic configuration into a helical equilibrium and chaos reduction follows, together with the formation of a null in the q shear. Strong temperature gradients develop, corresponding to a decreased thermal and particle transport. Turbulence analysis shows that the large electron temperature gradients are limited by the onset of micro-tearing modes, in addition to residual magnetic chaos. A new type of electron transport barrier with strong temperature gradients develops more externally (r/a = 0.8) accompanied by a 30% improvement of the global confinement time. The mechanism responsible for the formation of such a barrier is still unknown but it is likely associated with a local reduction of magnetic chaos. These external barriers develop primarily in situations of well-conditioned walls so that they might be regarded as attempts towards an L-H transition. Both types of barriers occur in high-current low-collisionality regimes. Analogies with tokamak and stellarators are discussed.
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| 17. |
- Chiodin, G, et al.
(författare)
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High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL
- 2022
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Ingår i: Blood advances. - : American Society of Hematology. - 2473-9537 .- 2473-9529. ; 6:18, s. 5494-5504
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Tidskriftsartikel (refereegranskat)abstract
- Chronic lymphocytic leukemia (CLL) cells have variably low surface IgM (sIgM) levels/signaling capacity, influenced by chronic antigen engagement at tissue sites. Within these low levels, CLL with relatively high sIgM (CLLhigh) progresses more rapidly than CLL with low sIgM (CLLlow). During ibrutinib therapy, surviving CLL cells redistribute into the peripheral blood and can recover sIgM expression. Return of CLL cells to tissue may eventually recur, where cells with high sIgM could promote tumor growth. We analyzed time to new treatment (TTNT) following ibrutinib in 70 patients with CLL (median follow-up of 66 months) and correlated it with pretreatment sIgM levels and signaling characteristics. Pretreatment sIgM levels correlated with signaling capacity, as measured by intracellular Ca2+ mobilization (iCa2+), in vitro (r = 0.70; P < .0001). High sIgM levels/signaling strongly correlated with short TTNT (P < .05), and 36% of patients with CLLhigh vs 8% of patients with CLLlow progressed to require a new treatment. In vitro, capacity of ibrutinib to inhibit sIgM-mediated signaling inversely correlated with pretherapy sIgM levels (r = −0.68; P = .01) or iCa2+ (r = −0.71; P = .009). In patients, sIgM-mediated iCa2+ and ERK phosphorylation levels were reduced by ibrutinib therapy but not abolished. The residual signaling capacity downstream of BTK was associated with high expression of sIgM, whereas it was minimal when sIgM expression was low (P < .05). These results suggested that high sIgM levels facilitated CLL cell resistance to ibrutinib in patients. The CLL cells, surviving in the periphery with high sIgM expression, include a dangerous fraction that is able to migrate to tissue and receive proliferative stimuli, which may require targeting by combined approaches.
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| 18. |
- Ebersole, Charles R., et al.
(författare)
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Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability
- 2020
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Ingår i: Advances in Methods and Practices in Psychological Science. - : Sage. - 2515-2467 .- 2515-2459. ; 3:3, s. 309-331
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Tidskriftsartikel (refereegranskat)abstract
- Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3-9; median total sample = 1,279.5, range = 276-3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (Delta r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00-.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19-.50).
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| 19. |
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| 20. |
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