| 11. |
- Brito-Zerón, Pilar, et al.
(författare)
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Mortality risk factors in primary Sjögren syndrome : a real-world, retrospective, cohort study
- 2023
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Ingår i: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 61
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundWhat baseline predictors would be involved in mortality in people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the baseline characteristics collected at the time of diagnosis of SjS associated with mortality and to identify mortality risk factors for all-cause death and deaths related to systemic SjS activity measured by the ESSDAI score.MethodsIn this international, real-world, retrospective, cohort study, we retrospectively collected data from 27 countries on mortality and causes of death from the Big Data Sjögren Registry. Inclusion criteria consisted of fulfilling 2002/2016 SjS classification criteria, and exclusion criteria included chronic HCV/HIV infections and associated systemic autoimmune diseases. A statistical approach based on a directed acyclic graph was used, with all-cause and Sjögren-related mortality as primary endpoints. The key determinants that defined the disease phenotype at diagnosis (glandular, systemic, and immunological) were analysed as independent variables.FindingsBetween January 1st, 2014 and December 31, 2023, data from 11,372 patients with primary SjS (93.5% women, 78.4% classified as White, mean age at diagnosis of 51.1 years) included in the Registry were analysed. 876 (7.7%) deaths were recorded after a mean follow-up of 8.6 years (SD 7.12). Univariate analysis of prognostic factors for all-cause death identified eight Sjögren-related variables (ocular and oral tests, salivary biopsy, ESSDAI, ANA, anti-Ro, anti-La, and cryoglobulins). The multivariate CPH model adjusted for these variables and the epidemiological features showed that DAS-ESSDAI (high vs no high: HR = 1.68; 95% CI, 1.27–2.22) and cryoglobulins (positive vs negative: HR = 1.72; 95% CI, 1.22–2.42) were independent predictors of all-cause death. Of the 640 deaths with available information detailing the specific cause of death, 14% were due to systemic SjS. Univariate analysis of prognostic factors for Sjögren-cause death identified five Sjögren-related variables (oral tests, clinESSDAI, DAS-ESSDAI, ANA, and cryoglobulins). The multivariate competing risks CPH model adjusted for these variables and the epidemiological features showed that oral tests (abnormal vs normal results: HR = 1.38; 95% CI, 1.01–1.87), DAS-ESSDAI (high vs no high: HR = 1.55; 95% CI, 1.22–1.96) and cryoglobulins (positive vs negative: HR = 1.52; 95% CI, 1.16–2) were independent predictors of SjS-related death.InterpretationThe key mortality risk factors at the time of SjS diagnosis were positive cryoglobulins and a high systemic activity scored using the ESSDAI, conferring a 2-times increased risk of all-cause and SjS-related death. ESSDAI measurement and cryoglobulin testing should be considered mandatory when an individual is diagnosed with SjS.
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| 12. |
- Daelman, Bo, et al.
(författare)
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Frailty and cognitive function in middle-aged and older adults with congenital heart disease
- 2024
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Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 83:12, s. 1149-1159
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Tidskriftsartikel (refereegranskat)abstract
- Background: Life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies have shown that older people with CHD have higher morbidity, health care use, and mortality. To maintain longevity and quality of life, understanding their evolving medical and psychosocial challenges is essential.Objectives: The authors describe the frailty and cognitive profile of middle-aged and older adults with CHD to identify predictor variables and to explore the relationship with hospital admissions and outpatient visits.Methods: Using a cross-sectional, multicentric design, we included 814 patients aged ≥40 years from 11 countries. Frailty phenotype was determined using the Fried method. Cognitive function was assessed by the Montreal Cognitive Assessment.Results: In this sample, 52.3% of patients were assessed as robust, 41.9% as prefrail, and 5.8% as frail; 38.8% had cognitive dysfunction. Multinomial regression showed that frailty was associated with older age, female sex, higher physiologic class, and comorbidities. Counterintuitively, patients with mild heart defects were more likely than those with complex lesions to be prefrail. Patients from middle-income countries displayed more prefrailty than those from higher-income countries. Logistic regression demonstrated that cognitive dysfunction was related to older age, comorbidities, and lower country-level income.Conclusions: Approximately one-half of included patients were (pre-)frail, and more than one-third experienced cognitive impairment. Frailty and cognitive dysfunction were identified in patients with mild CHD, indicating that these concerns extend beyond severe CHD. Assessing frailty and cognition routinely could offer valuable insights into this aging population.
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| 13. |
- de Brito, Almir Nunes, et al.
(författare)
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Tidal exchange in a choked coastal lagoon : A study of Mundaú Lagoon in northeastern Brazil
- 2018
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Ingår i: Regional Studies in Marine Science. - : Elsevier BV. - 2352-4855. ; 17, s. 133-142
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Tidskriftsartikel (refereegranskat)abstract
- Changes in the inlet morphology of choked coastal lagoons often restrict the water exchange with the sea, making them vulnerable to pollution events and eutrophication processes. In this study, the importance of tides for the water exchange was investigated in Mundaú Lagoon, which is a choked lagoon located in northeastern Brazil that has a very dynamic inlet and channel system. The analysis was carried out for critical scenarios during the dry season when the river flow to the lagoon decreases markedly. The concepts of integrated flushing time and spatially distributed residence time scales were applied using a Lagrangian particle tracking approach coupled with a hydrodynamic model. The flushing time of Mundaú Lagoon was estimated to be 12.6 days during neap tide and 5.7 days during spring tide, including a return flow factor. Employing an e-folding form, the corresponding value was calculated to be 64 and 54 days for particles allowed and not allowed to return to the lagoon, respectively. The spring tides were responsible for the most pronounced water exchange in the Mundaú Lagoon. Different particles release times displayed the effect of the initial tidal conditions on the flushing time; lower exchange times were estimated for releases during ebb tides and spring tides. The integrated estimation of the water exchange when imposing a scenario of most frequent wind conditions indicated a considerable delay caused by this forcing, increasing the flushing time up to 23 days. Another observed effect of the wind was a spatial redistribution of the tidal exchange in the lagoon into different zones with similar residence time.
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| 14. |
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| 15. |
- Nunes De Brito Junior, Almir, et al.
(författare)
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A STUDY ON THE WATER EXCHANGE IN MUNDAÚ LAGOON, NORTHEASTERN BRAZIL DURING THE DRY SEASON
- 2017. - 2017
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Ingår i: Proceedings of Coastal Dynamics 2017. ; , s. 1251-1260
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Konferensbidrag (refereegranskat)abstract
- Changes in the inlet morphology of choked coastal lagoons often restrict the water exchange with the sea, making them vulnerable to pollution release and eutrophication processes. In this study, the role of tides for the water exchange was investigated in a choked lagoon for critical scenarios during the low river flow season. Both an integrated and spatially distributed approach were employed using Lagrangian tracking of particles. The spring tides were responsible for the most pronounced water exchange and the spatially distributed approach identified different zones with similar water exchange characteristics. The tide action was primarily limited to the southern portion of the lagoon presenting a zone with rapid exchange times, whereas the other parts involved lower exchange and consequently long renewal times making it a more vulnerable area to different types of pollution releases.
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| 16. |
- Nunes De Brito Junior, Almir, et al.
(författare)
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MORPHOLOGICAL MODELING OF TIDAL INLET EVOLUTION: AN APPLICATION TO MUNDAÚ INLET, BRAZIL
- 2019
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Ingår i: Coastal Sediments 2019. - : WORLD SCIENTIFIC. - 9789811204494
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study was to develop a morphological model for long-term inlet evolution to be applied using a minimum amount of input data and requiring low computational costs. The model was implemented numerically and then validated for a real inlet application: Mundaú inlet (northeastern Brazil), a dynamic inlet with a marked freshwater seasonality and alongshore sand transport, reduced by reef sheltering. The model performance was verified, over a total period of 11 years, comparing the simulated inlet width with Landsat and Google Earth images. The simulated inlet channel morphology presented a satisfactory agreement with observations. With the low computational costs, the developed model represented a reliable approach with demonstrated potential to be applied in the quantitative assessment of inlet evolution over long time periods.
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| 17. |
- Potapov, Anton M., et al.
(författare)
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Global fine-resolution data on springtail abundance and community structure
- 2024
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Ingår i: Scientific Data. - : Nature Publishing Group. - 2052-4463. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Springtails (Collembola) inhabit soils from the Arctic to the Antarctic and comprise an estimated ~32% of all terrestrial arthropods on Earth. Here, we present a global, spatially-explicit database on springtail communities that includes 249,912 occurrences from 44,999 samples and 2,990 sites. These data are mainly raw sample-level records at the species level collected predominantly from private archives of the authors that were quality-controlled and taxonomically-standardised. Despite covering all continents, most of the sample-level data come from the European continent (82.5% of all samples) and represent four habitats: woodlands (57.4%), grasslands (14.0%), agrosystems (13.7%) and scrublands (9.0%). We included sampling by soil layers, and across seasons and years, representing temporal and spatial within-site variation in springtail communities. We also provided data use and sharing guidelines and R code to facilitate the use of the database by other researchers. This data paper describes a static version of the database at the publication date, but the database will be further expanded to include underrepresented regions and linked with trait data.
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| 18. |
- Rodrigues, Clarinda, et al.
(författare)
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Multi-sensory brand-experience : towards a strategic sensorial approach
- 2011
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Konferensbidrag (refereegranskat)abstract
- This paper is mainly conceptual in nature. It aims at developing a strategic sensorial brand approach for firms on the basis of three issues: 1) branding as a process of value co-creation, 2) the multi-sensory brand-experience, and 3) sensorial strategies in relation to brand experiences and brand as image.
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| 19. |
- Rodrigues, Clarinda, et al.
(författare)
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Sensorial brand strategies for value co-creation
- 2011
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Ingår i: Innovative Marketing. - Sumy : Business Perspectives. - 1814-2427. ; 7:2, s. 40-47
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Tidskriftsartikel (refereegranskat)abstract
- This research investigates the potential benefits of a fair co-branding operation. Two major corporate brands are fictitiously allied with a Fair Trade labeling organization brand. The sample for the first study is composed by 540 interviews, and by 350 for the second study; it is representative of the French population. Besides showing that the paradigm of co-branding is consistent to evaluate brand alliances between corporate and Fair Trade brands, the PLS model implemented in this research first investigates how do classical variables (attitudes, fit, similarity) are antecedents of co-branding relevancy and customers’ evaluation of the alliance. Second, this study introduces a new explicative variable based on the similarity-dissimilarity of the brands on FairTrade related aspects. The results obtained through the test of a PLS (Partial Least Square) model are a first step to better understand co-branding between corporate and labeling brands. This study also provides findings concerning the whole paradigm of cooperation between profit and non-profit organizations. In this type of brand alliance, the corporate brand provides the alliance with its leading position, and the Fair Trade brand provides the ethical attribute.
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| 20. |
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