SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Chanock S) "

Sökning: WFRF:(Chanock S)

  • Resultat 11-20 av 275
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  •  
12.
  •  
13.
  •  
14.
  •  
15.
  •  
16.
  •  
17.
  • Clark, DW, et al. (författare)
  • Associations of autozygosity with a broad range of human phenotypes
  • 2019
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
  • Tidskriftsartikel (refereegranskat)abstract
    • In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
  •  
18.
  •  
19.
  • Locke, Adam E, et al. (författare)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
  •  
20.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-20 av 275
Typ av publikation
tidskriftsartikel (264)
konferensbidrag (8)
annan publikation (2)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (253)
övrigt vetenskapligt/konstnärligt (22)
Författare/redaktör
Chanock, SJ (121)
Giles, GG (101)
Easton, DF (101)
Chanock, Stephen J (95)
Haiman, CA (91)
Southey, MC (88)
visa fler...
Chang-Claude, J (85)
Dunning, AM (82)
Brenner, H (79)
Hall, P (79)
Le Marchand, L (76)
Kraft, P (76)
Milne, RL (75)
Garcia-Closas, M (75)
Pharoah, PDP (75)
Fasching, PA (74)
Hopper, JL (73)
Czene, K (72)
Hunter, DJ (72)
Beckmann, MW (71)
Nevanlinna, H (69)
Chenevix-Trench, G (69)
Couch, FJ (67)
Mannermaa, A (67)
Lubinski, J (67)
Kraft, Peter (66)
Hamann, U (65)
Bojesen, SE (65)
Schmidt, MK (64)
Nordestgaard, BG (64)
Benitez, J. (63)
Dork, T (63)
Dennis, J (62)
Cox, A (62)
Lambrechts, D (62)
Andrulis, IL (60)
Zheng, W. (59)
Margolin, S (58)
Devilee, P (58)
Anton-Culver, H (57)
Peto, J (57)
Lindblom, A (56)
Albanes, Demetrius (56)
Brauch, H (56)
Jakubowska, A (56)
Bolla, MK (55)
Blomqvist, C (54)
Burwinkel, B (54)
Radice, P (53)
Truong, T (53)
visa färre...
Lärosäte
Karolinska Institutet (220)
Uppsala universitet (87)
Umeå universitet (83)
Lunds universitet (72)
Göteborgs universitet (16)
Handelshögskolan i Stockholm (2)
visa fler...
Högskolan Dalarna (2)
Örebro universitet (1)
Linköpings universitet (1)
Chalmers tekniska högskola (1)
visa färre...
Språk
Engelska (275)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (158)
Naturvetenskap (5)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy