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| 15. |
- Isaksson, B, et al.
(författare)
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Obstructive jaundice results in increased liver expression of uncoupling protein 2 and intact skeletal muscle glucose metabolism in the rat
- 2002
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 37:1, s. 104-111
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Tidskriftsartikel (refereegranskat)abstract
- Background: A majority of patients with pancreatic cancer have obstructive jaundice and diabetes with skeletal muscle insulin resistance. Surgery for these patients is associated with significant morbidity. Uncoupling protein 2 (UCP2) has been proposed to regulate energy expenditure and promote liver vulnerability. The effects of obstructive jaundice on muscle glucose metabolism and expression of UCP2 in liver and muscle are unknown. Methods: Rats were operated with bile duct ligation (BDL). After 7 days, UCP2 mRNA levels were determined in liver and muscle. Simultaneously, insulin-stimulated glucose transport and glycogen synthesis in skeletal muscle were analyzed in vitro. Results: The jaundiced rats lost more weight than pair-fed controls. UCP2 mRNA levels were increased 5-fold in liver but not in muscle in jaundiced rats compared to pair-fed controls. The jaundiced rats were hypoglycemic and hypoinsulinemic but demonstrated intact or enhanced insulin action on skeletal muscle glucose transport and glycogen synthesis in vitro. Muscle glycogen content was increased in the jaundiced rats. Conclusions: Experimental obstructive jaundice in the rat is associated with increased liver expression of UCP2. rapid weight loss, and intact insulin action on skeletal Muscle glucose metabolism. Obstructive jaundice. by upregulated liver UCP2. may contribute to the cachexia and high surgical morbidity observed in these patients, but not to skeletal muscle insulin resistance in pancreatic cancer patients.
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| 18. |
- Morrow, S A, et al.
(författare)
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High-resolution study of the C-12(gamma,p gamma')B-11 reaction using a HpGe detector to resolve excited states of B-11 through the observation of their gamma-ray decays
- 2006
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Ingår i: Physical Review C: covering nuclear physics. ; 73
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Tidskriftsartikel (refereegranskat)abstract
- Relative populations of states in 11B following the 12C(,p)11B reaction have been measured with high resolution using a 70% HpGe detector to observe decay rays from the residual nucleus. The triplet of states near 7 MeV in 11B are resolved and the measured populations compared to previous data. The analysis includes a consideration of -proton angular correlations, which was not made in the previous measurement. The new and previous results corrected for angular correlation effects agree reasonably well with calculations that include one- and two-body nuclear currents, pion exchange, and currents, under the assumption that the photons are mainly absorbed on exchanged pions.
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| 19. |
- O'Dwyer, J, et al.
(författare)
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Methanesulfonic acid in a Svalbard ice core as an indicator of ocean climate
- 2000
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Ingår i: GEOPHYSICAL RESEARCH LETTERS. - 0094-8276. ; 27:8, s. 1159-1162
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Tidskriftsartikel (refereegranskat)abstract
- Methanesulfonic acid (MSA) is an atmospheric oxidation product of dimethyl sulfide, produced by marine biota. MSA preserved in a Svalbard glacier between 1920 and 1996 is compared with the sea surface temperature (SST) and sea-ice extent of the surrounding ocean over the same period. On decadal timescales high MSA concentrations are found to be associated with warm SST and reduced sea-ice extent. MSA appears to be influenced by climatic changes related to variations in the import of warm Atlantic Water to the Barents Sea. Atlantic Water plays an important role in the Arctic climate system, therefore MSA concentrations may indirectly reflect larger-scale changes in the region and may be useful as a proxy for past climate.
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| 20. |
- Olsson, B, et al.
(författare)
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Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes
- 2003
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Ingår i: American Journal of Physiology: Endocrinology and Metabolism. - : American Physiological Society. - 1522-1555 .- 0193-1849. ; 285:3, s. 504-511
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Tidskriftsartikel (refereegranskat)abstract
- Transgenic mice overexpressing growth hormone (GH) have been extensively used to study the chronic effects of elevated serum levels of GH. GH is known to have many acute effects in the liver, but little is known about the chronic effects of GH overexpression on hepatic gene expression. Therefore, we used DNA microarray to compare gene expression in livers from bovine GH (bGH)-transgenic mice and littermates. Hepatic expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) and genes involved in fatty acid activation, peroxisomal and mitochondrial beta-oxidation, and production of ketone bodies was decreased. In line with this expression profile, bGH-transgenic mice had a reduced ability to form ketone bodies in both the fed and fasted states. Although the bGH mice were hyperinsulinemic, the expression of sterol regulatory element-binding protein (SREBP)-1 and most lipogenic enzymes regulated by SREBP-1 was reduced, indicating that these mice are different from other insulin-resistant models with respect to expression of SREBP-1 and its downstream genes. This study also provides several candidate genes for the well-known association between elevated GH levels and cardiovascular disease, e.g., decreased expression of scavenger receptor class B type I, hepatic lipase, and serum paraoxonase and increased expression of serum amyloid A-3 protein. We conclude that bGH-transgenic mice display marked changes in hepatic genes coding for metabolic enzymes and suggest that GH directly or indirectly regulates many of these hepatic genes via decreased expression of PPARalpha and SREBP-1.
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