| 11. |
- Sollerman, J., et al.
(författare)
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SN 1998bw at late phases
- 2000
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 537:2, s. L127-L130
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Tidskriftsartikel (refereegranskat)abstract
- We present observations of the peculiar supernova SN 1998bw, which was probably associated with GRB 980435. The photometric and spectroscopic evolution is monitored up to 500 days past explosion. We also present modeling based on spherically symmetric, massive progenitor models and very energetic explosions. The models allow line identification and clearly show the importance of mixing. From the late light curves, we estimate that similar to 0.3-0.9 M. of ejected Ni-56 is required to power the supernova.
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| 12. |
- Sollerman, J., et al.
(författare)
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The late-time light curve of the type Ia supernova 2000cx
- 2004
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 428, s. 555-568
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Tidskriftsartikel (refereegranskat)abstract
- We have conducted a systematic and comprehensive monitoring programme of the type Ia supernova 2000cx at late phases using the VLT and HST. The VLT observations cover phases 360 to 480 days past maximum brightness and include photometry in the BVRIJH bands, together with a single epoch in each of U and K_s. While the optical bands decay by about 1.4 mag per 100 days, we find that the near-IR magnitudes stay virtually constant during the observed period. This means that the importance of the near-IR to the bolometric light curve increases with time. The finding is also in agreement with our detailed modeling of a type Ia supernova in the nebular phase. In these models, the increased importance of the near-IR is a temperature effect. We note that this complicates late-time studies where often only the V band is well monitored. In particular, it is not correct to assume that any optical band follows the bolometric light curve at these phases, and any conclusions based on such assumptions, e.g., regarding positron-escape, must be regarded as premature. A very simple model where all positrons are trapped can reasonably well account for the observations. The nickel mass deduced from the positron tail of this light curve is lower than found from the peak brightness, providing an estimate of the fraction of late-time emission that is outside of the observed wavelength range. Our detailed models show the signature of an infrared catastrophe at these epochs, which is not supported by the observations. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Programmes 67.D-0134 and 68.D-0114). Also based in part on observations with the NASA/ESA Hubble Space Telescope. These HST observations are associated with proposals GO-8602 and GO-9114.i Tables \ref{t1}, \ref{t2}, \ref{t4} and \ref{t5} are only available in electronic form at http://www.edpsciences.org
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| 13. |
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Johansson, Gunnar, et al.
(författare)
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Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors.
- 2008
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Ingår i: Molecular Cancer Therapeutics. - 1535-7163 .- 1538-8514. ; 7:5, s. 1237-45
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Tidskriftsartikel (refereegranskat)abstract
- Malignant peripheral nerve sheath tumors (MPNST) are chemoresistant sarcomas with poor 5-year survival that arise in patients with neurofibromatosis type 1 (NF1) or sporadically. We tested three drugs for single and combinatorial effects on collected MPNST cell lines and in MPNST xenografts. The mammalian target of rapamycin complex 1 inhibitor RAD001 (Everolimus) decreased growth 19% to 60% after 4 days of treatment in NF1 and sporadic-derived MPNST cell lines. Treatment of subcutaneous sporadic MPNST cell xenografts with RAD001 significantly, but transiently, delayed tumor growth, and decreased vessel permeability within xenografts. RAD001 combined with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib caused additional inhibitory effects on growth and apoptosis in vitro, and a small but significant additional inhibitory effect on MPNST growth in vivo that were larger than the effects of RAD001 with doxorubicin. RAD001 plus erlotinib, in vitro and in vivo, reduced phosphorylation of AKT and total AKT levels, possibly accounting for their additive effect. The results support the consideration of RAD001 therapy in NF1 patient and sporadic MPNST. The preclinical tests described allow rapid screening strata for drugs that block MPNST growth, prior to tests in more complex models, and should be useful to identify drugs that synergize with RAD001.
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| 18. |
- Kozma, Radoslav, 1987-, et al.
(författare)
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Past and potential future population dynamics of three grouse species using ecological and whole genome coalescent modeling
- 2018
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 8:13, s. 6671-6681
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Tidskriftsartikel (refereegranskat)abstract
- Studying demographic history of species provides insight into how the past has shaped the current levels of overall biodiversity and genetic composition of species, but also how these species may react to future perturbations. Here we investigated the demographic history of the willow grouse (Lagopus lagopus), rock ptarmigan (Lagopus muta), and black grouse (Tetrao tetrix) through the Late Pleistocene using two complementary methods and whole genome data. Species distribution modeling (SDM) allowed us to estimate the total range size during the Last Interglacial (LIG) and Last Glacial Maximum (LGM) as well as to indicate potential population subdivisions. Pairwise Sequentially Markovian Coalescent (PSMC) allowed us to assess fluctuations in effective population size across the same period. Additionally, we used SDM to forecast the effect of future climate change on the three species over the next 50years. We found that SDM predicts the largest range size for the cold-adapted willow grouse and rock ptarmigan during the LGM. PSMC captured intraspecific population dynamics within the last glacial period, such that the willow grouse and rock ptarmigan showed multiple bottlenecks signifying recolonization events following the termination of the LGM. We also see signals of population subdivision during the last glacial period in the black grouse, but more data are needed to strengthen this hypothesis. All three species are likely to experience range contractions under future warming, with the strongest effect on willow grouse and rock ptarmigan due to their limited potential for northward expansion. Overall, by combining these two modeling approaches, we have provided a multifaceted examination of the biogeography of these species and how they have responded to climate change in the past. These results help us understand how cold-adapted species may respond to future climate changes.
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| 19. |
- Leloudas, G., et al.
(författare)
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The normal Type Ia SN 2003hv out to very late phases
- 2009
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 505:1, s. 265-279
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Tidskriftsartikel (refereegranskat)abstract
- Aims: We study a thermonuclear supernova (SN), emphasizing very late phases. Methods: An extensive dataset for SN 2003hv that covers the flux evolution from maximum light to day +786 is presented. This includes 82 epochs of optical imaging, 24 epochs of near-infrared (NIR) imaging, and 10 epochs of optical spectroscopy. These data are combined with published nebular-phase IR spectra, and the observations are compared to model light curves and synthetic nebular spectra. Results: SN 2003hv is a normal Type Ia supernova (SN Ia) with photometric and spectroscopic properties consistent with its rarely observed B-band decline-rate parameter, Δ m15(B) = 1.61 ± 0.02. The blueshift of the most isolated [Fe ii] lines in the nebular-phase optical spectrum appears consistent with those observed in the IR at similar epochs. At late times there is a prevalent color evolution from the optical toward the NIR bands. We present the latest-ever detection of a SN Ia in the NIR in Hubble Space Telescope images. The study of the ultraviolet/optical/infrared (UVOIR) light curve reveals that a substantial fraction of the flux is “missing” at late times. Between 300 and 700 days past maximum brightness, the UVOIR light curve declines linearly following the decay of radioactive 56Co, assuming full and instantaneous positron trapping. At 700 days we detect a possible slowdown of the decline in optical-bands, mainly in the V-band. Conclusions: The data are incompatible with a dramatic infrared catastrophe (IRC). However, the idea that an IRC occurred in the densest regions before 350 days can explain the missing flux from the UVOIR wavelengths and the flat-topped profiles in the NIR. We argue that such a scenario is possible if the ejecta are clumpy. The observations suggest that positrons are most likely trapped in the ejecta. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Programmes 073.D-0294(AB), 074.D-0259(BC) and 075.D-0116(AB)), Cerro Tololo Inter-American Observatory, Lick Observatory, Las Campanas Observatory, Siding Spring Observatory, and the Hubble Space Telescope. Tables 3, 4, and Appendix A are only available in electronic form at http://www.aanda.org
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| 20. |
- Meeuwsen, John A.L., et al.
(författare)
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High levels of (un)switched memory B cells are associated with better outcome in patients with advanced atherosclerotic disease
- 2017
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 6:9
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Tidskriftsartikel (refereegranskat)abstract
- Background--Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B-cell subtypes with the occurrence of secondary cardiovascular events in advanced atherosclerotic disease. Methods and Results--This cohort study consists of 168 patients who were included in the Athero-Express biobank between 2009 and 2011. Before surgery, peripheral blood mononuclear cells were isolated and stored in liquid nitrogen. After gentle thawing of the peripheral blood mononuclear cells, different B-cell subtypes including naïve, (un)switched memory, and CD27+CD43+ B1-like B cells, were analyzed by flow cytometry. Univariable and multivariable Cox proportional hazard models were used to analyze associations between B-cell subtypes, circulating antibodies and secondary cardiovascular manifestations during the 3-year follow-up period. Mean age was 70.1±9.6 years, males represented 62.8% of the population, and 54 patients had secondary manifestations during follow-up. High numbers of unswitched memory cells were protective against secondary outcome (hazard ratio, 0.30 [95% CI, 0.13-0.69]; P < 0.01). Similar results were obtained for the switched memory cells that also showed to be protective against secondary outcome (hazard ratio, 0.33 [95% CI, 0.14-0.77]; P = 0.01). Conclusions--A high number of (un)switched memory B cells is associated with better outcome following carotid artery endarterectomy. These findings suggest a potential role for B-cell subsets in prediction and prevention of secondary cardiovascular events in patients with atherosclerosis.
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