| 11. |
- Dlugosz, Aldona, et al.
(författare)
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No difference in small bowel microbiota between patients with irritable bowel syndrome and healthy controls
- 2015
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Several studies have indicated that colonic microbiota may exhibit important differences between patients with irritable bowel syndrome (IBS) and healthy controls. Less is known about the microbiota of the small bowel. We used massive parallel sequencing to explore the composition of small bowel mucosa-associated microbiota in patients with IBS and healthy controls. We analysed capsule biopsies from the jejunum of 35 patients (26 females) with IBS aged 18-(36)-57 years and 16 healthy volunteers (11 females) aged 20-(32)-48 years. Sequences were analysed based on taxonomic classification. The phyla with the highest total abundance across all samples were: Firmicutes (43%), Proteobacteria (23%), Bacteroidetes (15%), Actinobacteria (9.3%) and Fusobacteria (7.0%). The most abundant genera were: Streptococcus (19%), Veillonella (13%), Prevotella (12%), Rothia (6.4%), Haemophilus (5.7%), Actinobacillus (5.5%), Escherichia (4.6%) and Fusobacterium (4.3%). We found no difference among major phyla or genera between patients with IBS and controls. We identified a cluster of samples in the small bowel microbiota dominated by Prevotella, which may represent a common enterotype of the upper small intestine. The remaining samples formed a gradient, dominated by Streptococcus at one end and Escherichia at the other.
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| 12. |
- Duraj, Frans, et al.
(författare)
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Tarmtransplantation : Första svenska tunntarmstransplantationen till en vuxen patient med pseudoobstruktion
- 1998
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 95:28-29, s. 3172-3176
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Tidskriftsartikel (refereegranskat)abstract
- Recent advances, first and foremost the development of new immunosuppressive agents, have markedly improved the outcome of intestinal transplantation, which is a treatment option for patients with serious intestinal diseases who have become dependent on total parenteral nutrition. The first small bowel transplantation in Sweden was performed at Huddinge Hospital in 1997, in the adult patient with intestinal pseudo-obstruction. The article reports the course of this patient and an update of international progress in intestinal transplantation.
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| 13. |
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| 14. |
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| 15. |
- Gisselman, Fredrik, et al.
(författare)
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Ekosystemtjänstförteckning med inventering av dataunderlag : för kartläggning av ekosystemtjänster och grön infrastruktur
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- EKOSYSTEMTJÄNSTER ÄR IDAG ett relativt välkänt och etablerat begrepp. Som en följdav att fler aktörer i samhället nu arbetar med ekosystemtjänster har behovet av strukturerade klassificeringar, enhetliga namn och redogörelser av tillgängliga datakällor ökat. Därmed har behov uppstått av en enhetlig och lättillgänglig svensk förteckning.Rapporten har tre primära syften: i) att presentera en svensk förteckning över ekosystemtjänster med enhetliga och lättillgängliga namn, ii) att skapa en överblick över tillgängliga dataunderlag för varje ekosystemtjänst med syfte att förenkla och effektivisera kartläggningar, kvantifieringar och värderingar av ekosystemtjänster på lokal, regional och nationell nivå, samt iii) att identifiera brister avseende datatillgång för ekosystemtjänster.Intentionen med den svenska ekosystemtjänstförteckningen som presenteras i denna rapport är att skapa en bruttolista över ekosystemtjänster som är relevanta för Sverige, och koppla dessa till tillgängliga datakällor avseende tillgång på ekosystemtjänster. Förteckningen ska fungera som underlag vid identifiering, kartläggning, uppföljning och värdering av ekosystemtjänster. Den svenska förteckningen utgår från Common International Classification of Ecosystem Services (CICES), men har ett bredare syfte, därför har strukturen i vissa delar anpassats. Den svenska förteckningen innefattar också ett tillägg med kategorin stödjande ekosystemtjänster eftersom den ofta används.Rapporten inleds med en översiktlig genomgång av olika ekosystemtjänstklassificeringar. Detta följs sedan av en beskrivning av hur förslaget till nationell förteckning tagits fram, en diskussion kring skillnader på tillgång och efterfrågan samt en indelning utifrån geografiska aspekter. Därefter presenteras den uppdaterade svenska ekosystemtjänstförteckningen.Rapporten innehåller också en inventering av datakällor som kan användas för respektive ekosystemtjänst utifrån den föreslagna klassificeringen (digital bilaga). Slutligen redovisar vi, utifrån den föreslagen förteckning och tillgängliga dataunderlag, var det är mest angeläget att förbättra tillgången på underlagsdata.
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| 16. |
- Greger, Maria, et al.
(författare)
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Silicate reduces cadmium uptake into cells of wheat
- 2016
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Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491 .- 1873-6424. ; 211, s. 90-97
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Tidskriftsartikel (refereegranskat)abstract
- Cadmium (Cd) is a health threat all over the world and high Cd content in wheat causes high Cd intake. Silicon (Si) decreases cadmium content in wheat grains and shoot. This work investigates whether and how silicate (Si) influences cadmium (Cd) uptake at the cellular level in wheat. Wheat seedlings were grown in the presence or absence of Si with or without Cd. Cadmium, Si, and iron (Fe) accumulation in roots and shoots was analysed. Leaf protoplasts from plants grown without Cd were investigated for Cd uptake in the presence or absence of Si using the fluorescent dye, Leadmium Green AM. Roots and shoots of plants subjected to all four treatments were investigated regarding the expression of genes involved in the Cd uptake across the plasma membrane (i.e. LCT1) and efflux of Cd into apoplasm or vacuole from the cytosol (i.e. HMA2). In addition, phytochelatin (PC) content and PC gene (PCS1) expression were analysed. Expression of iron and metal transporter genes (IRT1 and NRAMP1) were also analysed. Results indicated that Si reduced Cd accumulation in plants, especially in shoot. Si reduced Cd transport into the cytoplasm when Si was added both directly during the uptake measurements and to the growth medium. Silicate downregulated LCT1 and HMA2 and upregulated PCS1. In addition, Si enhanced PC formation when Cd was present. The IRT1 gene, which was downregulated by Cd was upregulated by Si in root and shoot facilitating Fe transport in wheat. NRAMP1 was similarly expressed, though the effect was limited to roots. This work is the first to show how Si influences Cd uptake on the cellular level.
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| 17. |
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| 18. |
- Iwarzon, Marie, et al.
(författare)
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Functional status, health-related quality of life and symptom severity in patients with chronic intestinal pseudo-obstruction and enteric dysmotility
- 2009
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 44:6, s. 700-707
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To investigate whether patients with chronic intestinal pseudo-obstruction (CIP) differ from those with enteric dysmotility (ED) regarding self-reported measures of functional status, health-related quality of life (HRQoL) and gastrointestinal symptoms. Material and methods. The study comprised 28 patients with CIP (median age 48, range 28-80 years) and 26 with ED (median age 50, range 20-75 years). Three self-administered questionnaires were used: the Sickness Impact Profile (SIP), the Swedish HRQoL Questionnaire (SWED-QUAL) and the Gastrointestinal Symptom Rating Scale (GSRS). Results. Patients with CIP reported significantly greater functional impairment in the aggregated physical dimension of SIP (15.4 SD 19.7) than did patients with ED (5.0 SD 7.2, p0.01). They also reported significantly poorer general health (SWED-QUAL) (28.0 SD 20.8) compared to those with ED (44.8 SD 25.2, p 0.01). Symptom severity correlated with several measures of HRQoL and functional status in patients with CIP but abdominal pain severity was the only independent predictor of HRQoL. Abdominal pain alone explained between 21% and 67% of the variance in SWED-QUAL subscales. Likewise, the severity of indigestion symptoms among patients with CIP explained 20-24% of the variance in the SIP subscales, emotional behaviour and work. Much less correlation between symptom severity and functional impairment or HRQoL was found in patients with ED. We found no difference in symptom severity (GSRS) between the two groups. Conclusions. Patients with CIP reported a greater impairment of functional status and HRQoL than did patients with ED. Symptom severity had a stronger influence on functional status and HRQoL in patients with CIP.
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| 19. |
- Jansson-Rehnberg, Ann-Sofie, et al.
(författare)
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Diarrhoea of unknown cause: medical treatment in a stepwise manner Management of Idiopathic Diarrhoea Based on Experience of Step-Up Medical Treatment
- 2024
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Ingår i: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. - : TAYLOR & FRANCIS LTD. - 0036-5521 .- 1502-7708.
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Forskningsöversikt (refereegranskat)abstract
- The basic principle for the treatment of idiopathic diarrhoea (functional diarrhoea K59.1) is to delay transit through the gut in order to promote the absorption of electrolytes and water. Under mild conditions, bulking agents may suffice. With increasing severity, antidiarrhoeal pharmaceuticals may be added in a stepwise manner. In diarrhoea of unknown aetiology, peripherally-acting opioid receptor agonists, such as loperamide, are first-line treatment and forms the pharmaceutical basis of antidiarrheal treatment. As second-line treatment opium drops have an approved indication for severe diarrhoea when other treatment options fail. Beyond this, various treatment options are built on experience with more advanced treatments using clonidine, octreotide, as well as GLP-1 and GLP-2 analogs which require specialist knowledge the field.
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| 20. |
- Jansson-Rehnberg, Ann Sofie, et al.
(författare)
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Viktigt att stegvis öka insatser vid farmakologisk diarrébehandling : Pharmacological treatment of idiopathic diarrhea
- 2023
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Ingår i: Läkartidningen. - 0023-7205. ; 120
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The basic principle for treatment of idiopathic diarrhea is to delay transit through the gut in order to promote absorption of electrolytes and water. Under mild conditions bulking agents may suffice. With increasing severity, antidiarrheal pharmaceuticals may be added in a stepwise manner. Bile salt malabsorption is a clear indication for adsorptive resins, while in idiopathic diarrhea peripherally-acting opioid receptor agonists, such as loperamide, is the first-line treatment. Second-line treatment with approved indication for severe diarrhea when other treatment options fail includes opium drops. More advanced treatments are to be used by clinicians with specialist knowledge and experience in the field.
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