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Träfflista för sökning "WFRF:(Lindberg Per) srt2:(1980-1999)"

Sökning: WFRF:(Lindberg Per) > (1980-1999)

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11.
  • Hessman, Ola, et al. (författare)
  • Mutation of the Multiple Endocrine Neoplasia Type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas
  • 1998
  • Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 58:3, s. 377-379
  • Tidskriftsartikel (refereegranskat)abstract
    • Endocrine pancreatic tumors are rare neoplasms that occur sporadically or as part of a multiple endocrine neoplasia type 1 (MEN1) syndrome. Germ-line mutations of the MEN1 gene, located at 11q13, have been demonstrated in MEN1 kindreds, and loss of heterozygosity (LOH) on 11q13 together with somatic MEN1 mutations have been detected in 20% of nonfamilial parathyroid tumors. Here, we examine 11 non-MEN1 malignant tumors of the endocrine pancreas, 9 nonfunctioning tumors, and 2 glucagonomas. LOH of at least one informative locus on 11q13 was found in 70% of the tumors. Three tumors displayed somatic mutations of the MEN1 gene together with LOH on 11q13, whereas the corresponding germ-line DNA was normal. These findings support the hypothesis that MEN1 gene mutations contribute to the tumorigenesis of nonfamilial, malignant endocrine pancreatic tumors.
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14.
  • Lindberg, Lars, et al. (författare)
  • Inhaled nitric oxide reveals and attenuates endothelial dysfunction after lung transplantation
  • 1996
  • Ingår i: Annals of Thoracic Surgery. - 1552-6259. ; 62:6, s. 1639-1643
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Maintaining endothelial function within transplanted organs may be critical to successful preservation. In this study we have evaluated the relationship between the effect of inhalation of nitric oxide and the degree of endothelial dysfunction after lung transplantation. METHODS: A left lung, which had been preserved for 24 hours, was transplanted and a right pneumonectomy was performed in 5 pigs. After a 24-hour observation period the pigs inhaled 5, 20, and 80 ppm nitric oxide, and pulmonary vascular resistance was recorded continuously. From the same donors preserved pulmonary arteries from the contralateral lung were studied simultaneously in organ baths. Acetylcholine chloride was used to elicit endothelium-dependent relaxation in vessel segments contracted with the thromboxane A2 analogue U-46619. RESULTS: Maximal endothelium-dependent relaxation decreased in the preserved lungs and correlated to the pulmonary vascular resistance in the simultaneously transplanted lungs. Inhalation of nitric oxide in the pigs that had received transplants caused the pulmonary vessels to dilate in proportion to the endothelial dysfunction. CONCLUSIONS: Preservation of lung for transplantation induces an endothelial dysfunction, and the degree of the decrease in pulmonary vascular resistance caused by nitric oxide inhalation may be an indication of the degree of this endothelial damage. The vasodilation caused by inhaled nitric oxide increases as the endothelial function deteriorates.
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19.
  • Lindberg, T, et al. (författare)
  • Celiaki - en ny folksjukdom?
  • 1996
  • Ingår i: Tema: Barn. ; 50, s. 6-33
  • Forskningsöversikt (populärvet., debatt m.m.)
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20.
  • Simonsson, Per, et al. (författare)
  • Carbohydrate-deficient transferrin measured by high-performance liquid chromatography and CDTect immunoassay
  • 1996
  • Ingår i: Alcohol and Alcoholism. - 1464-3502. ; 31:4, s. 397-402
  • Tidskriftsartikel (refereegranskat)abstract
    • Carbohydrate-deficient transferrin (CDT) was measured in three populations using anion-exchange chromatography followed by radioimmunoassay (CDTectTM) and a new high-performance liquid chromatography (HPLC) method. The correlation between the methods in 50 consecutive clinical samples was good (r = 0.87). However, in a set of 49 samples with CDT concentrations close to the reference value of the methods, the correlation was low (r = 0.51). In addition, among controls, no correlation between the methods was found (r = 0.10). Abnormal isoforms of transferrin were noted in 5% of the clinical samples. HPLC determination of CDT offers the advantage of identifying these isoforms of transferrin and thus reducing analytical pitfalls associated with the CDTectTM method.
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  • Resultat 11-20 av 25
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Hellman, Per (2)
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