| 11. |
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| 12. |
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| 13. |
- Olsson, Martin L, et al.
(författare)
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The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein
- 1998
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048. ; 103:4, s. 1184-1191
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Tidskriftsartikel (refereegranskat)abstract
- The molecular basis of the three major alleles (Fy(a)/Fy(b)/Fy) of the Duffy (FY) blood group system has recently been established but the Fy(x) phenotype associated with weak expression of the Fy(b) and other FY antigens is poorly understood. In the Fy(x) genes of five unrelated British and Swedish donors with the Fy(a+b+weak) phenotype we found two missense mutations predicting amino acid changes Arg89Cys and Ala100Thr in the FY glycoprotein. The same mutations were found in two Fy(a-b+weak) samples from individuals of Swedish and Algerian origin. Their red blood cells showed a marked decrease in Fy(b), Fy3 and Fy6 expression measured by routine serology and flow cytometry. The rare FY genotypes Fy(x)Fy(x) and Fy(x)Fy were confirmed by family studies and DNA sequencing. Screening by allele-specific primer PCR (ASP-PCR) for these mutations among 100 Caucasian and 100 Black random blood donors indicated allele frequencies of 2.5% and 0% respectively. Ala100Thr alone was present in 33% of the Caucasians (but none of the Blacks) with no weakening of FY expression. A novel allele at the FY locus associated with the Fy(x) phenotype was studied. Mistyping of this weak Fy(b) antigen in clinical transfusion medicine may lead to delayed haemolytic transfusion reactions in immunized patients. A potential role for genomic typing is proposed.
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| 14. |
- Orton, G, et al.
(författare)
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Earth-based observations of the Galileo probe entry site
- 1996
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Ingår i: SCIENCE. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075. ; 272:5263, s. 839-840
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Tidskriftsartikel (refereegranskat)abstract
- Earth-based observations of Jupiter indicate that the Galileo probe probably entered Jupiter's atmosphere just inside a region that has less cloud cover and drier conditions than more than 99 percent of the rest of the planet. The visual appearance of the
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| 16. |
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| 17. |
- Lai, S.J., et al.
(författare)
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A simulation model of adaptive protocols in distributed computing systems with mobile hosts
- 1995
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Ingår i: Proceedings of the 28th Annual Simulation Symposium. - Los Alamitos, Calif : IEEE Communications Society. - 0818670916 ; , s. 220-227
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Konferensbidrag (refereegranskat)abstract
- Simulation is a scientific method which is largely dominated by computers and has allowed the testing and assessment of many models before actual implementation. The paper proposes an approach to construction of a simulation that models the behaviour of an adaptive queuing protocol (AQP). AQP was developed for database applications on mobile computers in a distributed multidatabase environment but can also be used in many other areas including distributed operating systems. By constructing the simulation model it is possible to both prove that it can be implemented, and at the same time study its expected behaviour in a mobile computing environment. The results of the simulation are analysed and discussed
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| 18. |
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| 19. |
- Lehtinen, T, et al.
(författare)
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Electrochemical characterization of PVDF-based proton conducting membranes for fuel cells
- 1998
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Ingår i: Electrochimica Acta. - 0013-4686 .- 1873-3859. ; 43, s. 1881-1890
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Tidskriftsartikel (refereegranskat)abstract
- The electrochemical characterization of proton-conducting membranes prepared by irradiation-induced grafting and subsequent sulfonation of PVDF films has been performed. In particular, measurements of the ionic conductivity, oxygen solubility and diffusion in the membranes are presented, as well as kinetic data for the oxygen reduction reaction in a membrane-platinum system and a simulation of the performance of these PVDF-g-PSSA membranes in a solid polymer electrolyte fuel cell using a microcathode technique. At sufficient degrees of grafting (>40%) the conductivity reaches 0.1 Scm−1, well above that of Nafion 117 (DuPont). The PVDF-g-PSSA membranes show lower solubilities and higher diffusion coefficients of oxygen and a higher water uptake than Nafion 117. The microcathode measurements indicate that those PVDF-g-PSSA membranes which have a conductivity higher than that of Nafion 117 may also give improved performance in fuel cell conditions provided that they have the necessary mechanical and chemical stability.
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| 20. |
- Poinar, HN, et al.
(författare)
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Molecular coproscopy: Dung and diet of the extinct ground sloth Nothrotheriops shastensis
- 1998
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Ingår i: SCIENCE. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075. ; 281:5375, s. 402-406
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- DNA from excrements can be amplified by means of the polymerase chain reaction. However, this has not been possible with ancient feces. Cross-Links between reducing sugars and amino groups were shown to exist in a Pleistocene coprolite from Gypsum Cave, N
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