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11.	Yang, R, et al. (author) Amnion signals are essential for mesoderm formation in primates 2021 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 5126- Journal article (peer-reviewed)abstract Embryonic development is largely conserved among mammals. However, certain genes show divergent functions. By generating a transcriptional atlas containing >30,000 cells from post-implantation non-human primate embryos, we uncover that ISL1, a gene with a well-established role in cardiogenesis, controls a gene regulatory network in primate amnion. CRISPR/Cas9-targeting of ISL1 results in non-human primate embryos which do not yield viable offspring, demonstrating that ISL1 is critically required in primate embryogenesis. On a cellular level, mutant ISL1 embryos display a failure in mesoderm formation due to reduced BMP4 signaling from the amnion. Via loss of function and rescue studies in human embryonic stem cells we confirm a similar role of ISL1 in human in vitro derived amnion. This study highlights the importance of the amnion as a signaling center during primate mesoderm formation and demonstrates the potential of in vitro primate model systems to dissect the genetics of early human embryonic development.

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Result 11-11 of 11

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Type of publication: journal article (11)

Type of content: peer-reviewed (11)

Author/Editor: Liu, X (2); Zhang, Z. (2); Zhao, X. (2); Li, X. (2); Zhang, Y. (2); Wang, Y. (2); show more...; Chen, Z. (2); Almqvist, C (2); Linnarsson, S (2); Wang, Q. (2); Liang, H. (2); Pan-Hammarstrom, Q (2); Malmberg, A (2); Ronkainen, J (2); Kogevinas, M (2); Lahti, J (2); Kajantie, E. (2); Snieder, H. (2); Allen, S (2); Karhunen, V. (2); Yeung, E (2); Heude, B (2); Felix, JF (2); Jaddoe, VWV (2); Sebert, S (2); Herceg, Z (2); Karlsson, R (2); Goldman, M (2); Streit, F (2); Frank, J (2); Witt, SH (2); Page, C. (2); Annesi-Maesano, I (2); Hivert, MF (2); Czamara, D (2); Bakken, TE (2); Hodge, RD (2); Bartlett, A (2); Nery, JR (2); Niu, SY (2); Siletti, K (2); Behrens, MM (2); Mukamel, EA (2); Ren, B (2); Ecker, JR (2); Preissl, S (2); Nawrot, TS (2); Baiz, N (2); London, SJ (2); Vafeiadi, M (2); show less...

University: Karolinska Institutet (7); Lund University (3); University of Gothenburg (1); Umeå University (1); Uppsala University (1); Chalmers University of Technology (1); show more...; Swedish University of Agricultural Sciences (1); show less...

Language: English (11)

Research subject (UKÄ/SCB): Natural sciences (3); Medical and Health Sciences (3)

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