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- Silveira, L. L., et al.
(författare)
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Comparative Study of the Corrosion and Cavitation Resistance of HVOF and HVAF FeCrMnSiNi and FeCrMnSiB Coatings
- 2017
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Ingår i: Proceedings of the International Thermal Spray Conference & Exposition (ITSC 2017). - New York : Curran Associates, Inc. - 9781510858220 ; , s. 675-680
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Konferensbidrag (refereegranskat)abstract
- Cavitation and corrosion on hydrodynamic components and systems reduces the operational efficiency. The use of wear resistant coatings have been studied as a solution to the problem of corrosion and cavitation in the industrial environment. Thermal spray processes are recognized as excellent technique to deposit coatings. The high velocity oxy-fuel process (HVOF) can produce high density and bond strength coatings. High velocity air-fuel process (HVAF) is an alternative process, shown to be superior regarding corrosion protection and production costs. HVAF can deposit coating with shorter dwell time and lower temperature, producing coating with lower oxide content This paper presents the use of HVOF and HVAF process to deposit FeCrMnSiNi and FeCrMnSiB coatings, studying the resistance against corrosion and cavitation in comparison to 316L HVOF coating. Microstructure was analyzed by XRD, microscopic means and mechanical testing. Cavitation and corrosion behavior of the coatings were also studied comparatively. HVAF coatings presented lower porosity and oxide levels, as well as higher hardness values, compared with the coatings deposited by HVOF process. The HVAF process presented better cavitation resistance than HVOF coatings. The FeCrMnSiNi HVAF coating had the best corrosion protection performance between the developed alloys.
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- Bollampalli, V. P., et al.
(författare)
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BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming
- 2015
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Ingår i: PLoS Pathogens. - : Public Library of Science. - 1553-7366 .- 1553-7374. ; 11:10
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Tidskriftsartikel (refereegranskat)abstract
- The transport of antigen from the periphery to the draining lymph node (DLN) is critical for T-cell priming but remains poorly studied during infection with Mycobacterium bovis Bacille Calmette-Guérin (BCG). To address this we employed a mouse model to track the traffic of Dendritic cells (DCs) and mycobacteria from the BCG inoculation site in the skin to the DLN. Detection of BCG in the DLN was concomitant with the priming of antigen-specific CD4+ T cells at that site. We found EpCAMlow CD11bhigh migratory skin DCs to be mobilized during the transport of BCG to the DLN. Migratory skin DCs distributed to the T-cell area of the LN, co-localized with BCG and were found in close apposition to antigen-specific CD4+ T cells. Consequently, blockade of skin DC traffic into DLN dramatically reduced mycobacterial entry into DLN and muted T-cell priming. Interestingly, DC and mycobacterial entry into the DLN was dependent on IL-1R-I, MyD88, TNFR-I and IL-12p40. In addition, we found using DC adoptive transfers that the requirement for MyD88 in BCG-triggered migration was not restricted to the migrating DC itself and that hematopoietic expression of MyD88 was needed in part for full-fledged migration. Our observations thus identify a population of DCs that contribute towards the priming of CD4+ T cells to BCG infection by transporting bacilli into the DLN in an IL-1R-MyD88-dependent manner and reveal both DC-intrinsic and -extrinsic requirements for MyD88 in DC migration.
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