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| 13. |
- Bulow, K, et al.
(författare)
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The penetration depth and lateral distribution of pigment related to the pigment grain size and the calendering of paper
- 2002
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - 0168-583X. ; 189, s. 308-314
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Tidskriftsartikel (refereegranskat)abstract
- The interaction of ink and newspaper has been investigated and the specific question of penetration of ink into the paper has been addressed with a nuclear microprobe using particle induced X-ray emission, The penetration depth of the newsprint is a critical factor in terms of increasing the quality of newsprint and minimising the amount of ink used. The objective of the experiment was to relate the penetration depth of pigment with the calendering of the paper, The dependence of the penetration depth on the pigment grain size was also Studied, To Study the penetration depth of pigment in paper, cyan ink with Cu as a tracer of the coloured pigment was used, For the study of the penetration depth dependence of pigment size. specially grounded Japanese ink with well-defined pigment grain size was used. This was compared to Swedish ink with pigment grains with normal size-distribution, The results show that the calendering of the paper considerably affects the penetration depth of ink. (C) 2002 Elsevier Science B.V. All rights reserved.
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| 16. |
- Mikus, MS, et al.
(författare)
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Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
- 2022
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 59:2
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Tidskriftsartikel (refereegranskat)abstract
- Asthma phenotyping requires novel biomarker discovery.ObjectivesTo identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs).MethodsAn antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by relation to objective OCS measures in U-BIOPRED.ResultsIn U-BIOPRED, 110 proteins were significantly different, mostly elevated, in SA compared to MMA and HCs. 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-β and glutathione S-transferase). OCS treatment decreased most proteins, yet differences between SA and MMA remained following correction for OCS use. Consensus clustering of U-BIOPRED protein data yielded six clusters associated with asthma control, quality of life, blood neutrophils, high-sensitivity C-reactive protein and body mass index, but not Type-2 inflammatory biomarkers. The mast cell specific enzyme carboxypeptidase A3 was one major contributor to cluster differentiation.ConclusionsThe plasma proteomic panel revealed previously unexplored yet potentially useful Type-2-independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.
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| 17. |
- Mpindi, JP, et al.
(författare)
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Consistency in drug response profiling
- 2016
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 540:7631, s. E5-E6
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Tidskriftsartikel (refereegranskat)
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