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Sökning: WFRF:(Protopopov M)

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  • Dehasque, Marianne, et al. (författare)
  • Temporal dynamics of woolly mammoth genome erosion prior to extinction
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • A large number of species have recently recovered from near-extinction events. Understanding the genetic consequences of severe population declines followed by demographic recoveries is key to predict the long-term viability of species in order to mitigate future extinction risks. Although these species have avoided the immediate extinction threat, their long-term viability remains questionable due to the genetic consequences of population declines, which are not understood on a time scale beyond a few generations. The woolly mammoth (Mammuthus primigenius) population on Wrangel Island is an excellent model system to investigate long-term genetic consequences of a population bottleneck. Mammoths became isolated on the island in the early Holocene due to rising sea levels, and persisted for over 200 generations (~6,000 years) before becoming extinct ~4,000 years ago. To study the evolutionary processes leading up to the extinction of the woolly mammoth on the island, we analysed 21 Siberian woolly mammoth genomes, including that of one of the last known mammoths. Our results show that the Wrangel Island mammoths recovered quickly from an initially severe bottleneck, and subsequently remained demographically stable during the ensuing 6 millennia. Further, we find that highly deleterious mutations were gradually purged from the population, whereas there was an accumulation of mildly deleterious mutations. The gradual purging of highly deleterious mutations suggests an ongoing inbreeding depression that lasted for hundreds of generations. This time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked present-day populations.
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  • VOROBIEVA, N, et al. (författare)
  • Localization of human ARF2 and NCK genes and 13 other NotI-linking clones to chromosome 3 by fluorescence in situ hybridization
  • 1995
  • Ingår i: Cytogenetics and cell genetics. - : S. Karger AG. - 0301-0171. ; 68:1-2, s. 91-94
  • Tidskriftsartikel (refereegranskat)abstract
    • Two human genes containing Notl sites, ADP-ribosylation factor (ARF2) and melanoma NCK protein, were mapped by fluorescence in situ hybridization to 3p21.2→ p21.1 and 3q21, respectively. Thirteen other <i>Not</i>I linking clones, representing sequence tagged sites, were also mapped to different regions of human chromosome 3. Two of these clones that contain sequences 80% homologous to the rat tropoelastin gene and brain Cl<sup>–</sup> channel protein CLC-2 gene probably represent new human genes closely related to the known rat genes.
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  • Resultat 11-17 av 17

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