| 11. |
- Ekener, Elisabeth, et al.
(författare)
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Operationalising and incorporating ethical considerations into a tool for multi-criteria decision making
- 2016
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Ingår i: International Journal of Multicriteria Decision Making. - : InderScience Publishers. - 2040-106X .- 2040-1078. ; 6:4, s. 290-315
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Tidskriftsartikel (refereegranskat)abstract
- In this study, an existing method for ethical analysis was extended by adding aspects of human rights and global distributional issues as framed by the United Nations (UN) Universal Declaration of Human Rights (UDHR) and the UN Millennium Development Goals (MDGs). A procedure for incorporating these issues together with environmental, safety and cost considerations into a decision making framework using multi-criteria decision analysis (MCDA) was devised. This includes a scoring system to convert qualitative ethical issues into semi-quantitative issues. The refined framework tool was tested in an illustrative case on the destruction of ammunition. The results showed that the extended framework for ethical analysis added value, for example as a way of highlighting ethical considerations in decision making. Use of the DecideIT software with its integrated MCDA improved the analysis by allowing for uncertain and imprecise values and estimations. The illustrative case results indicated that a combined alternative including recycling of metals and energetic materials had clear advantages over open detonation.
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| 12. |
- Engman, Cecilia, 1974, et al.
(författare)
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DNA adopts normal B-form upon incorporation of highly fluorescent DNA base analogue tC: NMR structure and UV-Vis spectroscopy characterization
- 2004
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 1362-4962 .- 0305-1048. ; 32:17, s. 5087-95
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Tidskriftsartikel (refereegranskat)abstract
- The influence of the highly fluorescent tricyclic cytosine base analogue (tC) on duplex DNA conformation is investigated. The duplex properties are characterized by absorbance and circular dichroism (CD) for all combinations of neighbouring bases to tC, and an NMR structure is determined for one tC-containing sequence. For the oligonucleotides with one tC incorporated instead of cytosine, the melting temperature is increased on average by 2.7 degrees C above that for the unmodified ones. CD spectra are practically identical for modified and unmodified sequences, indicating an unperturbed B-DNA conformation. The NMR structure determination of the self-complementary sequence 5'-CTC(tC)ACGTGGAG shows a DNA conformation consistent with B-form for the whole duplex. The root-mean-square distance for the nucleotides of the eight central base pairs between the 10 structures with lowest CYANA target functions and a mean structure is 0.45 +/- 0.17 A. The NMR data confirm correct base pairing for tC by the observation of both intrastrand and interstrand imino proton NOEs. Altogether, this suggests that tC works well as a cytosine analogue, i.e. it is situated in the base stack, forming hydrogen bonds with G in the complementary strand, without distorting the DNA backbone conformation. This first example of an artificial, highly fluorescent DNA base that does not perturb the DNA conformation could have valuable applications for the study of the structure and dynamics of nucleic acid systems.
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| 13. |
- Espinoza, Fredrik, et al.
(författare)
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GeoNotes: social and navigational aspects of location-based information systems
- 2001. - 1
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Ingår i: UBICOMP 2001. - : Swedish Institute of Computer Science.
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Location-based information systems allow the user to access information in relation to the user's position in geographical space. This paper outlines navigational and social aspects of such systems. It is argued that location-based systems must allow users to participate as content providers in order to achieve a social and dynamic information space. Moreover, as these systems allow commercial and private users to annotate space with information on a mass-scale, information filtering techniques will become essential in order to prevent information overload and user disturbance. We present a number of content-based and social filtering techniques to support this. We discuss implications for implementation and we describe a system (GeoNotes), which takes some of these aspects into account.
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| 14. |
- Fryland, Linda, et al.
(författare)
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Biomarkers in blood a few days after a bite by a Borrelia burgdorferi infected tick: : Asymptomatic Borrelia burgdorferi-infected subjects show higher Th1-associated response compared with subjects who later develop Lyme borreliosis
- 2012
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The clinical outcome following infection with Borrelia (B.) burgdorferi sensu lato (s.l.) differs between individuals, ranging from asymptomatic infection to Lyme borreliosis (LB) with persistent symptoms post-treatment. Previous studies in mice and humans have generated the hypothesis that a successful outcome of B. burgdorferi s.l. infection is associated with an early strong pro-inflammatory T helper (Th)1-like immune response. The aim of this study was to assess the early course of events in B. burgdorferi s.l.-associated inflammation by screening for possible early immune biomarkers in peripheral blood from newly tick-bitten persons. The study subjects bitten by B. burgdorferi s.l.-infected ticks were divided into (1) those later developing clinical LB, (2) those who developed anti-B. burgdorferi s.l. antibodies but not clinical LB, (3) those who neither developed antibodies nor clinical LB. A fourth group consisted of bitten study subjects without development of antibodies or clinical LB. Two sets of samples, both comprising all four groups, were collected in order to repeat the analyses and confirm the data. Sera or plasma collected a few days after the tick bite were analysed for 18 biomarkers (IL-1β, IL-6, CXCL8/IL-8, IL-12p70, IL-17A, IL-27, TNF, CCL18, CCL20, CCL22, CXCL1, CXCL9, CXCL10, CXCL11, calprotectin, MMP-3, MMP-8, MMP-9) by multiplex bead assay and ELISA. In the first set of samples, the neutrophil activation marker calprotectin was increased in subjects who developed clinical LB compared with subjects who developed antibodies against B. burgdorferi s.l. but did not develop LB. However, the finding could not be confirmed in the second set of samples, thus the study failed to identify an early prognostic marker for development of clinical LB. Interestingly, both sets of samples showed increases in two different Th1-associated markers, CXCL10 and IL-12p70, respectively, in subjects who following a bite by a B. burgdorferi s.l.-infected tick developed antibodies against B. burgdorferi s.l. but did not develop LB compared with subjects who developed clinical LB, thus supporting the hypothesis of an early strong Th1-response being important for optimal resolution of B. burgdorferi s.l. infection.
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| 15. |
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| 16. |
- Haettner Aurelius, Eva, et al.
(författare)
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Roller på livets och historiens scen. Drottning Kristinas bilder av sig själv
- 2013
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Ingår i: Bilder av Kristina. Drottning av Sverige - drottning i Rom. - 9789187594502 ; , s. 264-281
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Bokkapitel (refereegranskat)abstract
- Det tänkande som ligger under Kristinas självframställning - livet är ett skådespel - beskrivs, samt de genrebundna mönster för Kristinas jag som hon utnyttjar påvisas i Krisinas text, bl a Plutarkos biografi över Alexander den store, den kvinnliga helgonbiografin. Dessa kan knytas till Kristinas manliga klädsel, hennes transvestism samt till hennes bild av sitt offer(abdikationen)som ett hjältedåd.
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| 17. |
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| 18. |
- Höglund, Martin, et al.
(författare)
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Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry
- 2013
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 122:7, s. 1284-1292
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Tidskriftsartikel (refereegranskat)abstract
- Clinical management guidelines on malignant disorders are generally based on data from clinical trials with selected patient cohorts. In Sweden, more than 95% of all patients diagnosed with chronic myeloid leukemia (CML) are reported to the national CML registry, providing unique possibilities to compile population-based information. This report is based on registry data from 2002 to 2010, when a total of 779 patients (425 men, 354 women; median age, 60 years) were diagnosed with CML (93% chronic, 5% accelerated, and 2% blastic phase) corresponding to an annual incidence of 0.9/100 000. In 2002, approximately half of the patients received a tyrosine kinase inhibitor as initial therapy, a proportion that increased to 94% for younger (andlt;70 years) and 79% for older (andgt;80 years) patients during 2007-2009. With a median follow-up of 61 months, the relative survival at 5 years was close to 1.0 for patients younger than 60 years and 0.9 for those aged 60 to 80 years, but only 0.6 for those older than 80 years. At 12 months, 3% had progressed to accelerated or blastic phase. Sokal, but not European Treatment and Outcome Study, high-risk scores were significantly linked to inferior overall and relative survival. Patients living in university vs nonuniversity catchment areas more often received tyrosine kinase inhibitors up front but showed comparable survival.
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| 19. |
- Karlsson, Jerker, et al.
(författare)
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The impossibility of an ethical consumer
- 2013
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Ingår i: The ethics of consumption. - 9789086862313 ; , s. 183-188
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Bokkapitel (refereegranskat)abstract
- The thesis of this article is that the notion of an ethical food consumer is untenable unless it is coupled with a conception of food citizenship. The main arguments delivered against the notion of ethical food consumption are that consumption does not take the operations of moral psychology into account, nor afford means to tackle structural problems inherent in the relation between consumer and producer. The notion of an ethically aware food citizen is on the other hand capable of handling these problems head on. Hence, a realistic food ethics has to operate with an integrative view of consumption and citizenship.
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| 20. |
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