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Träfflista för sökning "WFRF:(Scobie M.) srt2:(2015-2019)"

Search: WFRF:(Scobie M.) > (2015-2019)

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11.	Sanjiv, K, et al. (author) Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities 2016 In: Cell reports. - : Elsevier BV. - 2211-1247. ; 17:12, s. 3407-3416 Journal article (peer-reviewed)
12.	Sanjiv, K, et al. (author) Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities 2016 In: Cell reports. - : Elsevier BV. - 2211-1247. ; 14:2, s. 298-309 Journal article (peer-reviewed)
13.	Sanjiv, K, et al. (author) MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells 2019 In: CANCER RESEARCH. - 0008-5472. ; 79:13 Conference paper (other academic/artistic)
14.	Biermann, F., et al. (author) Global goal setting for improving national governance and policy 2017 In: Governing Through Goals: Sustainable Development Goals as Governance Innovation. - : The MIT Press. - 9780262337410 - 9780262035620 ; , s. 75-96 Book chapter (other academic/artistic)
15.	Biermann, F., et al. (author) The Earth System Governance Project as a network organization : a critical assessment after ten years 2019 In: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 39, s. 17-23 Research review (peer-reviewed)abstract The social sciences have engaged since the late 1980s in international collaborative programmes to study questions of sustainability and global change. This article offers an in-depth analysis of the largest long-standing social-science network in this field: the Earth System Governance Project. Originating as a core project of the former International Human Dimensions Programme on Global Environmental Change, the Earth System Governance Project has matured into a global, self-sustaining research network, with annual conferences, numerous taskforces, research centers, regional research fellow meetings, three book series, an open access flagship journal, and a lively presence in social media. The article critically reviews the experiences of the Earth System Governance network and its integration and interactions with other programmes over the last decade.
16.	Sanjiv, K, et al. (author) Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell 2016 In: CANCER RESEARCH. - 0008-5472. ; 76 Conference paper (other academic/artistic)
17.	Visnes, Torkild, et al. (author) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation 2018 In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 362:6416, s. 834- Journal article (peer-reviewed)abstract The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 binding to and repair of 8-oxoG and which is well tolerated by mice. TH5487 prevents tumor necrosis factor-alpha-induced OGG1-DNA interactions at guanine-rich promoters of proinflammatory genes. This, in turn, decreases DNA occupancy of nuclear factor kappa B and proinflammatory gene expression, resulting in decreased immune cell recruitment to mouse lungs. Thus, we present a proof of concept that targeting oxidative DNA repair can alleviate inflammatory conditions in vivo.

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Result 11-17 of 17

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Type of publication: journal article (11); conference paper (4); research review (1); book chapter (1)

Type of content: peer-reviewed (12); other academic/artistic (5)

Author/Editor: Scobie, M (13); Helleday, T (11); Koolmeister, T (10); Sanjiv, K (8); Berglund, UW (7); Almlof, I. (7); show more...; Loseva, O (6); Jemth, AS (6); Homan, E (5); Wiita, E (5); Lundback, T (5); Mortusewicz, O (5); Hagenkort, A (5); Schultz, N (4); Altun, M (4); Desroses, M (4); Gad, H (4); Hoglund, A. (4); Calderon-Montano, JM (4); Artursson, Per (3); Baranczewski, P (3); Llona-Minguez, S (3); Gokturk, C (3); Kalderen, C. (3); Baranczewski, Pawel (3); Jensen, AJ (3); Gustavsson, AL (3); Jacques, SA (3); Henriksson, M (2); Herr, P (2); Stromberg, K. (2); Nilsson, Jonas A, 19 ... (2); Artursson, P (2); Axelsson, H. (2); Pham, T (2); Wallner, O (2); Visnes, T (2); Brautigam, L (2); Berglund, U. W. (2); Einarsdottir, Bergli ... (2); Saleh, A. (2); Wakchaure, P. (2); Biermann, F. (2); Rudd, SG (2); Mehdizadeh, A (2); Darabi, M (2); Jeppsson, F (2); Stenmark, P (2); Kuiper, RV (2); Sigmundsson, K (2); show less...

University: Karolinska Institutet (13); University of Gothenburg (3); Uppsala University (3); Royal Institute of Technology (2); Lund University (2); Stockholm University (1); show more...; Linköping University (1); RISE (1); show less...

Language: English (17)

Research subject (UKÄ/SCB): Medical and Health Sciences (5); Natural sciences (3); Engineering and Technology (1); Agricultural Sciences (1); Social Sciences (1)

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