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| 12. |
- Shu, Huan, et al.
(författare)
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Description of 1st trimester urinary levels of phthalate and phenol metabolites in 2,356 Swedish women in the SELMA study
- 2013
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Ingår i: Journal of Environmental Health Perspectives. - : National Institute of Environmental Health Science. - 0091-6765 .- 1552-9924. ; 121:S1
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BACKGROUND: Epidemiological studies have found the general population has been exposed to endocrine disrupting chemicals (EDCs) such as phthalates and phenols on a regular basis. Exposures to the developing fetus during critical points in the development are a concern. In the SELMA study we investigate the importance of pre and post natal exposure for EDCs and life style factors for development of chronic diseases in offspring such as asthma and allergy, reproductive related effects, neurodevelopmental disorders and metabolic effects including overweigh and obesity among small children in Sweden. OBJECTIVES: To evaluate the extent of exposure to phthalates and phenols in the urine of 2,356 SELMA pregnant women. METHODS: One spot urine sample was taken during the 1st trimester (wk 10) from 2,356 pregnant (mean age=30), the first visit at the midwifery clinic in Sweden. The samples were analyzed for 10 phthalate metabolites from six different phthalates, bisphenol A and triclosan. Urine was added with isotopically labeled internal standards, digested by glucoronidase and then analyzed by liquid chromatography tandem mass spectrometry without any further purification. The limits of detection (LODs) were between 0.01 and 0.1ng/ml and the coefficients of variation of the quality control samples generally better than 10%. RESULTS: All samples were above the LOD. The geometric mean and range of urinary concentration (ng/ml) was: MEP (68.39; [1.30-4419.35]), MBP (69.42; [3.03-2718.94]), MBzP (16.85; [0.25-3544.51]), MEHP (3.85; [0.14-213.09]), 5-oh (16.59; [0.24-1012.98]), 5-oxo (11.26; [0.05-611.77]), 5-cx (16.07; [0.73-757.17]), 7-oh (6.42; [0.06-1726.48]), 7-oxo (GM=2.98; [0.05-635.49]), 7-cx (10.03; [0.33-1661.24]), BPA (1.54; [0.05-111.26]), and Triclosan (1.25; [0.00-3356.79]). CONCLUSIONS: Exposure of phthalates and phenols are prevalent in Swedish pregnant women (highly susceptible population). Sources of exposure, uptake routes and health effects in children that associated with prenatal exposures will be investigated in the SELMA study.
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| 13. |
- Shu, Huan, 1980-, et al.
(författare)
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Prenatal phthalate exposure was associated with croup in Swedish infants
- 2018
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Ingår i: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 107:6, s. 1011-1019
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Tidskriftsartikel (refereegranskat)abstract
- AIM: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants.METHODS: From 2007-2010 we used liquid chromatography tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1,062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders.RESULTS: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1,062 infants during the first year of life, when adjusted for potential confounders. A dose response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life.CONCLUSION: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age.
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| 19. |
- Svensson, Bo, 1957
(författare)
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Beskattning av handelsbolag
- 2013
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Ingår i: Skattenytt. - 0346-1254. ; 63:6, s. 336-337
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 20. |
- Svensson, Bo, 1957
(författare)
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Beskattning av handelsbolag
- 2016
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Ingår i: Skattenytt. - 0346-1254. ; Rättsfallshäfte:6, s. 350-353
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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