| 11. |
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| 12. |
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| 13. |
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| 14. |
- Ambrosi, D., et al.
(författare)
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Perspectives on biological growth and remodeling
- 2011
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Ingår i: Journal of the mechanics and physics of solids. - : Elsevier BV. - 0022-5096 .- 1873-4782. ; 59:4, s. 863-883
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Forskningsöversikt (refereegranskat)abstract
- The continuum mechanical treatment of biological growth and remodeling has attracted considerable attention over the past fifteen years. Many aspects of these problems are now well-understood, yet there remain areas in need of significant development from the standpoint of experiments, theory, and computation. In this perspective paper we review the state of the field and highlight open questions, challenges, and avenues for further development.
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| 15. |
- Viborg Lindskrog, Sia, et al.
(författare)
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An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
- 2021
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provide independent prognostic value beyond established prognostic clinicopathological parameters. High chromosomal instability, p53-pathway disruption and APOBEC-related mutations are significantly associated with transcriptomic class 2a and poor outcome. RNA-derived immune cell infiltration is associated with chromosomally unstable tumors and enriched in class 2b. Spatial proteomics analysis confirms the higher infiltration of class 2b tumors and demonstrates an association between higher immune cell infiltration and lower recurrence rates. Finally, the independent prognostic value of the transcriptomic classes is documented in 1228 validation samples using a single sample classification tool. The classifier provides a framework for biomarker discovery and for optimizing treatment and surveillance in next-generation clinical trials.
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| 16. |
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| 17. |
- King, Thomas S., et al.
(författare)
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How does load and impulse influence the success of jettisoning a simulated S-92 push-out window?
- 2018
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Ingår i: International Journal of Industrial Ergonomics. - : Elsevier BV. - 1872-8219 .- 0169-8141. ; 68, s. 205-210
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Tidskriftsartikel (refereegranskat)abstract
- To address a gap in the collective knowledge base related to Helicopter Underwater Egress Training, this study examined the effectiveness of two typical strike techniques used to jettison a simulated Sikorsky S92 push-out window. Previous research has indicated that the jettison task may not be as straight forward as suggested by the “strike any corner” decals placed in corners of the push-out windows of the actual S92 helicopter. This study analyzed data provided from a larger study on the jettison task to determine how striking the simulated window with either the hand or elbow influenced the load and impulse which were generated as well as the likelihood of jettison success. Testing occurred in wet and dry conditions. Analysis of the data suggested that an elbow strike is highly successful while inverted underwater. The data also suggest that despite the difference between the hand and elbow strike success rate, the production of load between the wet and dry conditions for this type of strike was non-significant.
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| 18. |
- Kislitsyn, Dmitry A., et al.
(författare)
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Communication : Visualization and spectroscopy of defects induced by dehydrogenation in individual silicon nanocrystals
- 2016
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 144:24
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Tidskriftsartikel (refereegranskat)abstract
- We present results of a scanning tunneling spectroscopy (STS) study of the impact of dehydrogenation on the electronic structures of hydrogen-passivated silicon nanocrystals (SiNCs) supported on the Au(111) surface. Gradual dehydrogenation is achieved by injecting high-energy electrons into individual SiNCs, which results, initially, in reduction of the electronic bandgap, and eventually produces midgap electronic states. We use theoretical calculations to show that the STS spectra of midgap states are consistent with the presence of silicon dangling bonds, which are found in different charge states. Our calculations also suggest that the observed initial reduction of the electronic bandgap is attributable to the SiNC surface reconstruction induced by conversion of surface dihydrides to monohydrides due to hydrogen desorption. Our results thus provide the first visualization of the SiNC electronic structure evolution induced by dehydrogenation and provide direct evidence for the existence of diverse dangling bond states on the SiNC surfaces. Published by AIP Publishing.
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