| 11. |
- Gustafsson, Anna-Maria, et al.
(author)
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Heat extraction thermal response test in groundwater-filled borehole heat exchanger : Investigation of the borehole thermal resistance
- 2011
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In: Renewable energy. - : Elsevier BV. - 0960-1481 .- 1879-0682. ; 36:9, s. 2388-2394
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Journal article (peer-reviewed)abstract
- In groundwater-filled borehole heat exchangers (BHEs) convective flow influences the heat transfer in the borehole. During heat extraction thermal response tests (TRTs) the effect of the changing convective flow is more dominant than during heat injection tests. Water is heaviest around 4 °C and when exceeding this temperature during the test, the convective flow is stopped and restarted in the opposite direction resulting in a higher borehole thermal resistance during that time. Just before 0 °C the convective flow is the largest resulting in a much lower borehole thermal resistance. Finally, during the freezing period phase change energy is released and material parameters change as water is transformed into ice, resulting in a slightly higher borehole resistance than at a borehole water temperature of 0 °C. The changes in borehole thermal resistance are too large for ordinary analysis methods of thermal response tests to work. Instead another method is introduced where the borehole thermal resistance is allowed to change between different time intervals. A simple 1D model of the borehole is used, which is matched to give a similar mean fluid temperature curve as the measured one while keeping the bedrock thermal conductivity constant during the whole test. This method is more time-consuming than ordinary TRT analyses but gives a good result in showing how the borehole thermal resistance changes. Also, a CFD-model with a section of a simplified borehole was used to further study the effect of convection and phase change while the temperature was decreased below freezing point. The test and the model show similar results with large variations in the borehole thermal resistance. If the knowledge of changing borehole thermal resistance was used together with a design program including the heat pump and its efficiency, a better BHE system design would be possible.
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| 12. |
- Gustafsson, Anna-Maria, et al.
(author)
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Multi-injection rate thermal response test in groundwater filled borehole heat exchanger
- 2010
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In: Renewable energy. - : Elsevier BV. - 0960-1481 .- 1879-0682. ; 35:5, s. 1061-1070
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Journal article (peer-reviewed)abstract
- During a thermal response test (TRT) or during operation of a borehole heat exchanger (BHE) system, a temperature gradient in and around the borehole is achieved. This causes convective flow in the groundwater due to density differences. In groundwater filled BHE the convective heat flow influences the heat transport in the borehole system. The size of the influence depends on the injection rate used, which changes during the year for normal BHE systems. Multi-injection rate TRT (MIR TRT) may be used as a method to detect the convective heat influence and to examine the effect on the BHE thermal transport parameters. It was shown that MIR TRT constitutes a valuable method to detect fractured bedrock and to examine the effect of different heat injection rates. For boreholes located in solid bedrock only the borehole thermal resistance was influenced by the convective flow. An increase in heat injection rate resulted in a decrease in resistance. It was shown that the length of the collector did not affect the result. For the fractured bedrock the effective bedrock conductivity was also affected, an increase in heat injection rate resulted in a higher effective bedrock thermal conductivity.
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| 13. |
- Gustafsson, Anna-Maria, et al.
(author)
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Simulation of the thermal borehole resistance in groundwater filled borehole heat exchanger using CFD technique
- 2010
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In: International Journal of Energy and Environment. - 2076-2895 .- 2076-2909. ; 1:3, s. 399-410
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Journal article (peer-reviewed)abstract
- The thermal borehole resistance in a groundwater-filled borehole heat exchanger (BHE) is affected of both conductive and convective heat transfer through the borehole water. To calculate this heat transport, different models are required compared to calculation of only conductive heat transfer in a back-filled BHE. In this paper some modelling approximations for groundwater-filled, single U-pipe BHEs were investigated using a 3D CFD model. The purpose is to find approximations that enable to construct a fast, simple model including the convective heat transfer that may be used in thermal response test analyses and BHE design programs. Both total heat transfer calculations (including convective and conductive heat transport) and only conductive heat transfer calculations were performed for comparison purposes. The approximations that are investigated are the choice of boundary condition at the U-pipe wall and using a single pipe in the middle of the borehole instead of the U-pipe. For the total heat transfer case, it is shown that the choice of boundary condition hardly affects the calculated borehole thermal resistance. For the only conductive heat transfer case, the choice of boundary condition at the pipe wall gives large differences in the result. It is also shown that using an annulus model (single pipe in the middle of the borehole) results in similar heat transfer as the U-pipe model provided that the equivalent radius is chosen appropriately. This approximation can radically decrease the number of calculation cells needed.
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| 14. |
- Hamberg, Eva, et al.
(author)
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Kvantitativa metoder i empirisk livsåskådningsforskning
- 2010
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In: Mening och mönster. Bilder av teologi och livsåskådningsforskning. Festskrift till Carl Reinhold Bråkenhielm.. - 1102-7878. - 9789155477318 ; , s. 54-69
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Book chapter (other academic/artistic)
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| 15. |
- Hedskog, Louise, et al.
(author)
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Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
- 2013
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 110:19, s. 7916-7921
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Journal article (peer-reviewed)abstract
- It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER are referred to as mitochondria-associated ER membranes (MAMs), and they play an important role in, for example, lipid synthesis, calcium homeostasis, and apoptotic signaling. Perturbation of MAM function has previously been suggested in Alzheimer's disease (AD) as shown in fibroblasts from AD patients and a neuroblastoma cell line containing familial presenilin-2 AD mutation. The effect of AD pathogenesis on the ER-mitochondria interplay in the brain has so far remained unknown. Here, we studied ER-mitochondria contacts in human AD brain and related AD mouse and neuronal cell models. We found uniform distribution of MAM in neurons. Phosphofurin acidic cluster sorting protein-2 and sigma 1 receptor, two MAM-associated proteins, were shown to be essential for neuronal survival, because siRNA knockdown resulted in degeneration. Up-regulated MAM-associated proteins were found in the AD brain and amyloid precursor protein (APP)(Swe/Lon) mouse model, in which up-regulation was observed before the appearance of plaques. By studying an ER-mitochondria bridging complex, inositol-1,4,5-triphosphate receptor-voltage-dependent anion channel, we revealed that nanomolar concentrations of amyloid beta-peptide increased inositol-1,4,5-triphosphate receptor and voltage-dependent anion channel protein expression and elevated the number of ER-mitochondria contact points and mitochondrial calcium concentrations. Our data suggest an important role of ER-mitochondria contacts and cross-talk in AD pathology.
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| 16. |
- Heikkila, Katriina, et al.
(author)
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Job Strain and Alcohol Intake : A Collaborative Meta-Analysis of Individual-Participant Data from 140 000 Men and Women
- 2012
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7, s. Art. no. e40101-
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Journal article (peer-reviewed)abstract
- Background: The relationship between work-related stress and alcohol intake is uncertain. In order to add to the thus far inconsistent evidence from relatively small studies, we conducted individual-participant meta-analyses of the association between work-related stress (operationalised as self-reported job strain) and alcohol intake. Methodology and Principal Findings: We analysed cross-sectional data from 12 European studies (n = 142 140) and longitudinal data from four studies (n = 48 646). Job strain and alcohol intake were self-reported. Job strain was analysed as a binary variable (strain vs. no strain). Alcohol intake was harmonised into the following categories: none, moderate (women: 1-14, men: 1-21 drinks/week), intermediate (women: 15-20, men: 22-27 drinks/week) and heavy (women: > 20, men: > 27 drinks/week). Cross-sectional associations were modelled using logistic regression and the results pooled in random effects meta-analyses. Longitudinal associations were examined using mixed effects logistic and modified Poisson regression. Compared to moderate drinkers, non-drinkers and (random effects odds ratio (OR): 1.10, 95% CI: 1.05, 1.14) and heavy drinkers (OR: 1.12, 95% CI: 1.00, 1.26) had higher odds of job strain. Intermediate drinkers, on the other hand, had lower odds of job strain (OR: 0.92, 95% CI: 0.86, 0.99). We found no clear evidence for longitudinal associations between job strain and alcohol intake. Conclusions: Our findings suggest that compared to moderate drinkers, non-drinkers and heavy drinkers are more likely and intermediate drinkers less likely to report work-related stress.
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| 17. |
- Heikkila, Katriina, et al.
(author)
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Job strain and the risk of inflammatory bowel diseases : individual-participant meta-analysis of 95 000 men and women
- 2014
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2, s. e88711-
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Journal article (peer-reviewed)abstract
- Background and Aims: Many clinicians, patients and patient advocacy groups believe stress to have a causal role in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. However, this is not corroborated by clear epidemiological research evidence. We investigated the association between work-related stress and incident Crohn's disease and ulcerative colitis using individual-level data from 95 000 European adults. Methods: We conducted individual-participant data meta-analyses in a set of pooled data from 11 prospective European studies. All studies are a part of the IPD-Work Consortium. Work-related psychosocial stress was operationalised as job strain (a combination of high demands and low control at work) and was self-reported at baseline. Crohn's disease and ulcerative colitis were ascertained from national hospitalisation and drug reimbursement registers. The associations between job strain and inflammatory bowel disease outcomes were modelled using Cox proportional hazards regression. The study-specific results were combined in random effects meta-analyses. Results: Of the 95 379 participants who were free of inflammatory bowel disease at baseline, 111 men and women developed Crohn's disease and 414 developed ulcerative colitis during follow-up. Job strain at baseline was not associated with incident Crohn's disease (multivariable-adjusted random effects hazard ratio: 0.83, 95% confidence interval: 0.48, 1.43) or ulcerative colitis (hazard ratio: 1.06, 95% CI: 0.76, 1.48). There was negligible heterogeneity among the study-specific associations. Conclusions: Our findings suggest that job strain, an indicator of work-related stress, is not a major risk factor for Crohn's disease or ulcerative colitis.
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| 18. |
- Heikkila, K., et al.
(author)
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Job strain and the risk of severe asthma exacerbations : a meta-analysis of individual-participant data from 100 000 European men and women
- 2014
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 69:6, s. 775-783
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Journal article (peer-reviewed)abstract
- BackgroundMany patients and healthcare professionals believe that work-related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in working-age European men and women. MethodsWe analysed individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. Associations between job strain and asthma exacerbations were modelled using Cox regression and the study-specific findings combined using random-effects meta-analyses. ResultsDuring a median follow-up of 10years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code). In the age- and sex-adjusted analyses, job strain was associated with an increased risk of severe asthma exacerbations defined using the primary diagnostic code (hazard ratio, HR: 1.27, 95% confidence interval, CI: 1.00, 1.61). This association attenuated towards the null after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55). No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19). ConclusionsOur findings suggest that job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death.
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| 19. |
- Heikkila, Katriina, et al.
(author)
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Job Strain and Tobacco Smoking : An Individual-Participant Data Meta-Analysis of 166 130 Adults in 15 European Studies
- 2012
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7
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Journal article (peer-reviewed)abstract
- Background: Tobacco smoking is a major contributor to the public health burden and healthcare costs worldwide, but the determinants of smoking behaviours are poorly understood. We conducted a large individual-participant meta-analysis to examine the extent to which work-related stress, operationalised as job strain, is associated with tobacco smoking in working adults. Methodology and Principal Findings: We analysed cross-sectional data from 15 European studies comprising 166 130 participants. Longitudinal data from six studies were used. Job strain and smoking were self-reported. Smoking was harmonised into three categories never, ex- and current. We modelled the cross-sectional associations using logistic regression and the results pooled in random effects meta-analyses. Mixed effects logistic regression was used to examine longitudinal associations. Of the 166 130 participants, 17% reported job strain, 42% were never smokers, 33% ex-smokers and 25% current smokers. In the analyses of the cross-sectional data, current smokers had higher odds of job strain than never-smokers (age, sex and socioeconomic position-adjusted odds ratio: 1.11, 95% confidence interval: 1.03, 1.18). Current smokers with job strain smoked, on average, three cigarettes per week more than current smokers without job strain. In the analyses of longitudinal data (1 to 9 years of follow-up), there was no clear evidence for longitudinal associations between job strain and taking up or quitting smoking. Conclusions: Our findings show that smokers are slightly more likely than non-smokers to report work-related stress. In addition, smokers who reported work stress smoked, on average, slightly more cigarettes than stress-free smokers.
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| 20. |
- Heikkilä, K., et al.
(author)
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Job strain and health-related lifestyle : Findings from an individual-participant meta-analysis of 118 000 working adults
- 2013
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In: American Journal of Public Health. - 0090-0036 .- 1541-0048. ; 103:11, s. 2090-2097
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Journal article (peer-reviewed)abstract
- Objectives. We examined the associations of job strain, an indicator of work-related stress, with overall unhealthy and healthy lifestyles. Methods. We conducted a meta-analysis of individual-level data from 11 European studies (cross-sectional data: n = 118 701; longitudinal data: n = 43 971). We analyzed job strain as a set of binary (job strain vs no job strain) and categorical (high job strain, active job, passive job, and low job strain) variables. Factors used to define healthy and unhealthy lifestyles were body mass index, smoking, alcohol intake, and leisure-time physical activity. Results. Individuals with job strain were more likely than those with no job strain to have 4 unhealthy lifestyle factors (odds ratio [OR] = 1.25; 95% confidence interval [CI] = 1.12, 1.39) and less likely to have 4 healthy lifestyle factors (OR = 0.89; 95% CI = 0.80, 0.99). The odds of adopting a healthy lifestyle during study follow-up were lower among individuals with high job strain than among those with low job strain (OR = 0.88; 95% CI = 0.81, 0.96). Conclusions. Work-related stress is associated with unhealthy lifestyles and the absence of stress is associated with healthy lifestyles, but longitudinal analyses suggest no straightforward cause-effect relationship between workrelated stress and lifestyle. Copyright © 2013 by the American Public Health Association®.
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