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Träfflista för sökning "WFRF:(Zhang C. L.) srt2:(1995-1999)"

Search: WFRF:(Zhang C. L.) > (1995-1999)

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11.	Zhang, H, et al. (author) Synergistic inhibition of HIV-1 reverse transcriptase and HIV-1 replication by combining trovirdine with AZT, ddl and ddC in vitro 1996 In: ANTIVIRAL CHEMISTRY & CHEMOTHERAPY. - : SAGE Publications. - 0956-3202 .- 2040-2066. ; 7:5, s. 221-229 Journal article (other academic/artistic)abstract Trovirdine (LY300046·HCI) is a potent and selective non-nucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitor (Åhgren et al., Antimicrob Ag Chemother 39: 1329, 1995). Combinations of trovirdine with other RT inhibitors, AZT, ddC., ddl and their triphosphates, were studied as well as the pyrophosphate analogue PFA in both cell-free HIV-1 polymerase assays and HIV-1-infected MT-4 cell cultures. Synergistic effects and weak synergism were observed both using RT and HIV-1 - infected cells and using different HIV-1 RT mutants and HIV-1 drug-resistant variants known to be resistant to the inhibitory effects of trovirdine. The best combination with substantial synergism was ddC-TP and trovirdine at a 20:1 molar ratio combination in a cell-free enzyme assay. This combination showed the weak synergy in MT-4 cells. Synergism was judged by the median-effect method. The inhibitory effect of trovirdine was independent of increased concentrations of AZT triphosphate and ddC triphosphate implying that trovirdine acts in a mutually exclusive manner with AZT-TP and ddC-TP as determined by the Dixon plot. The combination effects were expressed by the combination index (Cl) using end points of 50%, 70% and 90% inhibition of HIV-1 RT activity and HIV-1 replication in MT-4 cells.
12.	Cantrell, AS, et al. (author) Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs 1996 In: Journal of medicinal chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 39:21, s. 4261-4274 Journal article (peer-reviewed)
13.	Guicheney, P, et al. (author) PCR based mutation screening of the laminin alpha2 chain gene (LAMA2): application to prenatal diagnosis and search for founder effects in congenital muscular dystrophy 1998 In: Journal of medical genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 35:3, s. 211-217 Journal article (peer-reviewed)
14.	Heidet, L, et al. (author) Somatic deletion of the 5' ends of both the COL4A5 and COL4A6 genes in a sporadic leiomyoma of the esophagus 1998 In: The American journal of pathology. - 0002-9440. ; 152:3, s. 673-678 Journal article (peer-reviewed)
15.	Hellberg, P.-E, et al. (author) Boron-doped polycrystalline SixGe1-x films : Dopant activation and solid solubility 1997 In: Journal of the Electrochemical Society. ; 144, s. 3968-3973 Journal article (peer-reviewed)
16.	Hellberg, P.-E. 1970-, et al. (author) Oxidation of silicon-germanium alloys. I. An experimental study 1997 In: Journal of Applied Physics. ; 82, s. 5773-5778 Journal article (peer-reviewed)
17.	Hellberg, P.-E. 1970-, et al. (author) Oxidation of silicon-germanium alloys. II. A mathematical model 1997 In: Journal of Applied Physics. ; 82, s. 5779-5787 Journal article (peer-reviewed)
18.	Hellberg, P.-E. 1970-, et al. (author) Work function of Boron-Doped polycrystalline SixGe1-x films 1997 In: IEEE Electron Device Letters. ; 18, s. 456-458 Journal article (peer-reviewed)
19.	Hogberg, M, et al. (author) Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues 1999 In: JOURNAL OF MEDICINAL CHEMISTRY. - 0022-2623. ; 42:20, s. 4150-4160 Journal article (other academic/artistic)abstract The further development-of allosteric HIV-1 RT inhibitors in the urea analogue series of PETT (phenylethylthiazolylthiourea) derivatives is described here. The series includes derivatives with an ethyl linker (1-5) and racemic (6-16) and enantiomeric (17-
20.	Hogberg, M, et al. (author) Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues 1999 In: Journal of medicinal chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 42:20, s. 4150-4160 Journal article (peer-reviewed)

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Result 11-20 of 27

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Type of publication: journal article (26); conference paper (1)

Type of content: peer-reviewed (24); other academic/artistic (3)

Author/Editor: Zhang, H. (7); OBERG, B (7); VRANG, L (7); SAHLBERG, C (6); UNGE, T (5); Zhang, X. (4); show more...; HOGBERG, M (4); JOHANSSON, NG (4); LIND, P (4); NOREEN, R (4); Zhang, S-L (4); Engelhardt, P (3); Kangasmetsa, J (3); Chen, Y. (2); Carius, Staffan (2); Chen, F (2); Cooper, M. D. (2); Mischke, R. E. (2); AHGREN, C (2); CANTRELL, AS (2); JASKUNAS, SR (2); JORDAN, CL (2); KINNICK, MD (2); MORIN, JM (2); MUESING, MA (2); PRANC, P (2); RYDERGARD, C (2); TERNANSKY, RJ (2); VASILEFF, RT (2); WEST, SJ (2); Schwartz, K. (2); Fisk, R. J. (2); Gagliardi, C. A. (2); Hogan, G. E. (2); Koetke, D. D. (2); Kroupa, M. A. (2); Piilonen, L. E. (2); Szymanski, J. J. (2); Tribble, R. E. (2); Tu, X. L. (2); Tryggvason, K (2); Hart, G. (2); Schilling, S. (2); Fridborg, K. (2); Topaloglu, H (2); Barois, A. (2); d'Heurle, F. M. (2); Guicheney, P (2); Vignier, N (2); Cruaud, C (2); show less...

University: Karolinska Institutet (14); Royal Institute of Technology (5); Uppsala University (4); Linnaeus University (3); Lund University (1)

Language: English (27)

Research subject (UKÄ/SCB): Engineering and Technology (5); Natural sciences (2); Medical and Health Sciences (1)

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