| 21. |
- Wang, Jiabin, et al.
(författare)
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Impact of bogie cavity shapes and operational environment on snow accumulating on the bogies of high-speed trains
- 2018
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Ingår i: Journal of Wind Engineering and Industrial Aerodynamics. - : Elsevier BV. - 0167-6105. ; 176, s. 211-224
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, the snow accumulation on the bogies of high-speed trains has been investigated using a numerical simulation method based on the unsteady Reynolds-Averaged Navier-Stokes simulations (URANS) coupled with the Discrete Phase Model (DPM). The effects of bogie cut outs’ shape, running speed of high-speed trains and snow particle density and diameter on the snow accumulation and particle movement characteristics are discussed. The results show that the bogie installation region with inclined plates shows better anti-snow performance than the configuration with straight plates, which greatly affects the flow structure and snow concentration distribution in the upper space of bogie regions. The running speed of high-speed trains has dominant effect on the snow accumulation on the bogies, and the snow accumulation issue of bogie becomes more serious with increasing running speed. Furthermore, the snow particle density and diameter also have large influence on the snow accumulation on the bogies. With the increase of snow particle density and diameter, the flow range at height direction around bogie region of snow particles become lower and the quality of snow accumulation decrease significantly.
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| 22. |
- Wang, Jiabin, et al.
(författare)
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Impact of rotation of wheels and bogie cavity shapes on snow accumulating on the bogies of high-speed trains
- 2019
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Ingår i: Cold Regions Science and Technology. - : Elsevier BV. - 0165-232X. ; 159, s. 58-70
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Tidskriftsartikel (refereegranskat)abstract
- The snow accumulation on the bogies of a high-speed train was studied using the unsteady Reynolds-Averaged Navier-Stokes simulations (URANS) coupled with the Discrete Phase Model (DPM). The effects of the rotation of wheels, shape of bogie fairings and length of bogie cavities on the flow characteristics and snow accumulation around bogie regions are discussed. The results show that the rotation of wheels significantly affects the flow characteristic and snow distribution around rear plates and the snow accumulation on the top surface of bogies. The shape of bogie fairings has been found to have large influence on the velocity profiles at the inlet and the outlet of bogie cavity, and thereby on the snow accumulation. The bogies without fairing have been found to be less influenced by the snow in the flows without crosswinds. The length of the bogie's cavity was found to have dominant role on the distribution of particle concentration and snow accumulation on the bogie surface. The total mass of snow accumulation on the bogie surface was shown to decrease with the shorter bogie cavity. Finally, the shorter bogie cavity is recommended for the design of the high-speed trains running under the circumstances permitted by the vehicle gauge.
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| 23. |
- Wheeler, Eleanor, et al.
(författare)
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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations : A transethnic genome-wide meta-analysis
- 2017
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Ingår i: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 14:9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance. Throughout this multiancestry study, we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.Methods & findings: Using genome-wide association meta-analyses in up to 159,940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants associated with HbA1c. We classified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G) were associated with higher T2D incidence in multiethnic longitudinal cohorts (N = 33,241). Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at genome-wide significance. GS-G was associated with higher T2D risk (incidence OR = 1.05, 95% CI 1.04-1.06, per HbA1c-raising allele, p = 3 x 10-29); whereas GS-E was not (OR = 1.00, 95% CI 0.99-1.01, p = 0.60). In Europeans and Asians, erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c. Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women. The G6PD variant may cause approximately 2% (N = 0.65 million, 95% CI0.55-0.74) of African American adults with T2Dto remain undiagnosed when screened with HbA1c. Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants. Further studies in large multiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action of the unclassified variants.Conclusions: As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
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| 24. |
- Yang, Dong, et al.
(författare)
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Air- and Light-Stable P-4 and As-4 within an Anion-Coordination-Based Tetrahedral Cage
- 2017
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Ingår i: Journal of the American Chemical Society. - : AMER CHEMICAL SOC. - 0002-7863 .- 1520-5126. ; 139:16, s. 5946-5951
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Tidskriftsartikel (refereegranskat)abstract
- In contrast to the stable dinitrogen molecule, white phosphorus (P-4) and yellow arsenic (As-4) are very reactive allotropic modifications of these two heavier pnictogen elements, which has greatly hampered the study of their properties and applications. Thus, the safe storage and transport of them is imperative. Supramolecular caged structures are one of the most efficient approaches for the encapsulation and stabilization of reactive species; however, their use in the P-4 and As-4 chemistry is very rare. In the current work, we demonstrate a new design strategy for constructing finite cages and including guests based on anion coordination chemistry. The phosphate-coordination-based tetrahedral cages can readily accommodate the tetrahedral guests P-4 and As-4, which is facilitated by the shape and size complementarity as well as favorable sigma-pi and lone-pair-pi interactions. Moreover, the latter case represents the first example of As-4 inclusion in a well-defined tetrahedral cage.
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| 25. |
- Yu, ChaoQing, et al.
(författare)
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Managing nitrogen to restore water quality in China
- 2019
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 567:7749, s. 516-520
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Tidskriftsartikel (refereegranskat)abstract
- The nitrogen cycle has been radically changed by human activities(1). China consumes nearly one third of the world's nitrogen fertilizers. The excessive application of fertilizers(2,3) and increased nitrogen discharge from livestock, domestic and industrial sources have resulted in pervasive water pollution. Quantifying a nitrogen 'boundary'(4) in heterogeneous environments is important for the effective management of local water quality. Here we use a combination of water-quality observations and simulated nitrogen discharge from agricultural and other sources to estimate spatial patterns of nitrogen discharge into water bodies across China from 1955 to 2014. We find that the critical surface-water quality standard (1.0 milligrams of nitrogen per litre) was being exceeded in most provinces by the mid-1980s, and that current rates of anthropogenic nitrogen discharge (14.5 +/- 3.1 megatonnes of nitrogen per year) to fresh water are about 2.7 times the estimated 'safe' nitrogen discharge threshold (5.2 +/- 0.7 megatonnes of nitrogen per year). Current efforts to reduce pollution through wastewater treatment and by improving cropland nitrogen management can partially remedy this situation. Domestic wastewater treatment has helped to reduce net discharge by 0.7 +/- 0.1 megatonnes in 2014, but at high monetary and energy costs. Improved cropland nitrogen management could remove another 2.3 +/- 0.3 megatonnes of nitrogen per year-about 25 per cent of the excess discharge to fresh water. Successfully restoring a clean water environment in China will further require transformational changes to boost the national nutrient recycling rate from its current average of 36 per cent to about 87 per cent, which is a level typical of traditional Chinese agriculture. Although ambitious, such a high level of nitrogen recycling is technologically achievable at an estimated capital cost of approximately 100 billion US dollars and operating costs of 18-29 billion US dollars per year, and could provide co-benefits such as recycled wastewater for crop irrigation and improved environmental quality and ecosystem services.
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| 26. |
- Yu, Zheng Lin, et al.
(författare)
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Environmental water flow can boost foraging success of the juvenile rapa whelk Rapana venosa (Muricidae) in aquaculture tanks with still or flowing water : Indication of chemosensory foraging
- 2019
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Ingår i: Aquaculture. - : Elsevier BV. - 0044-8486. ; 513
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Tidskriftsartikel (refereegranskat)abstract
- Artificial breeding of Rapana venosa has been attempted in China, but the high mortality rate of rapa whelk juveniles (10–40 mm) seriously restricts the breeding success of this species in artificial cultivation and the overall aquaculture industry, and thus the scale of industrialization is far from being realized. One main factor was found to contribute to this high mortality rate: the low predation efficiency of juveniles. We studied the foraging behavior of various sized R. venosa juveniles in still, flowing, and circulating water, with the juveniles being positioned either upstream or downstream from the prey in the flowing water experiments. Our findings demonstrated that the distance between juveniles and prey in still water significantly restricted the ability of juveniles to locate food, but water flow significantly enhanced this ability. In addition, the small-sized juveniles were found to be more active predators than the larger sized juveniles. Our findings demonstrated that circulating water flow is important to improve the survival and growth rate of juveniles in R. venosa cultures. Our results broaden the understanding of chemical orientation in gastropods and can be used to develop or improve commercial breeding strategies for R. venosa.
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| 27. |
- Zhang, Jiliang, 1985, et al.
(författare)
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An Experimental Study on Indoor Massive 3D-MIMO Channel at 30-40 GHz Band
- 2018
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Ingår i: ISAP 2018 - 2018 International Symposium on Antennas and Propagation.
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Konferensbidrag (refereegranskat)abstract
- Three-dimensional (3D) multiple-input multiple-output (MIMO) channel sounder measurements are producposed for a multi-user MIMO channel at the 30-40 GHz mm-wave band. A 3D-MIMO downlink transmissions links withto two users is considered. The measurement campaign employing a vector network analyzer (VNA) washas been performed in an indoor office scenario. Based on the measurement results, weThe characterizeations of mm-wave 3D-MIMO channels are performed in the wavenumber domain and the time domain, which are jointly analyzed via a 3D inverse fast Fourier transform (IFFT). Measurement shows that the massive 3D-MIMO has a significant improvement on resolution of multipathes beyond none-massive 3D-MIMO.
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| 28. |
- Zhang, Jie, et al.
(författare)
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The water-food-energy nexus optimization approach to combat agricultural drought : a case study in the United States
- 2018
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Ingår i: Applied Energy. - : ELSEVIER SCI LTD. - 0306-2619 .- 1872-9118. ; 227, s. 449-464
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Tidskriftsartikel (refereegranskat)abstract
- The frequent recent drought events in the Great Plains of United States have led to significant crop yield reductions and crop price surges. Using an integrated water-food-energy nexus modelling and optimization approach, this study laid the basis for developing an effective agricultural drought management system by combining real-time drought monitoring with real-time irrigation management. The proposed water-food-energy simulation and optimization method is spatially explicit and was applied to one major corn region in Nebraska. The crop simulations, validated with yield statistics, showed that a drought year like 2012 can potentially reduce the corn yield by 50% as compared to a wet year like 2009. The simulation results show that irrigation can play a key role in halting crop losses due to drought and in sustaining high yields of up to 20 t/ha. Nevertheless, the water-food-energy relationship shows that significant investments on water and energy are required to limit the negative effects of drought. The multi-criteria optimization problem developed in this study shows that the optimal crop yield does not necessarily correspond to the maximum yield, resulting in potential water and energy savings.
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| 29. |
- Zhang, Keliang, et al.
(författare)
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Rational design and kinetics study of flexible sodium-ion full batteries based on binder-free composite film electrodes
- 2019
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry. - 2050-7488 .- 2050-7496. ; 7:16, s. 9890-9902
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Tidskriftsartikel (refereegranskat)abstract
- A high-performance flexible sodium-ion full battery (FSIFB) is developed by using binder-free composite film (BFCF) electrodes without using conductive carbon and current collectors. Hard carbon fibers decorated with different electrochemical active materials are used as the supporting framework and 3D conductive network of FSIFBs for the first time. Different pre-sodiated anodes and the electrolyte additives are designed for well-matched FSIFBs. Using a porous Na3V2(PO4)(3) coated hard carbon fiber film with a mass loading of 2.34 mg cm(-2) as the cathode and a pre-sodiated graphene/SiC/hard carbon fiber film with a mass loading of 1.50 mg cm(-2) as the anode, an optimized FSIFB is designed. It delivers high output voltage (3.34 V), high energy density (234.1 W h kg(-1) at a high-current rate of 0.5 A g(-1)), ultralong cyclability (over 2905 cycles at 0.5 A g(-1) and 1000 cycles at 5 A g(-1)), and high coulombic efficiency (approaching 100%), which surpasses those of all FSIFBs reported so far. Furthermore, this FSIFB still maintains good electrochemical attributes even at serious bending states in water. The models of the solid electrolyte interphase behavior on the surface of electrodes in the FSIFB are studied by using EIS, and a reaction mechanism and an equivalent electrical circuit are proposed. We also provide the videos of the preparation process for a pouch-type FSIFB to demonstrate its simple operability and potential applications.
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| 30. |
- Zhang, Sicai, et al.
(författare)
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Identification and characterization of a novel botulinum neurotoxin
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (VAMP) 1, 2 and 3, but at a novel site (Arg66-Ala67 in VAMP2). Remarkably, BoNT/X is the only toxin that also cleaves non-canonical substrates VAMP4, VAMP5 and Ykt6. To validate its activity, a small amount of full-length BoNT/X was assembled by linking two non-toxic fragments using a transpeptidase (sortase). Assembled BoNT/X cleaves VAMP2 and VAMP4 in cultured neurons and causes flaccid paralysis in mice. Thus, BoNT/X is a novel BoNT with a unique substrate profile. Its discovery posts a challenge to develop effective countermeasures, provides a novel tool for studying intracellular membrane trafficking, and presents a new potential therapeutic toxin for modulating secretions in cells.
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