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Sökning: WFRF:(Franco EL)

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  • DAddio, Francesca, et al. (författare)
  • The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
  • 2022
  • Ingår i: Nature Communications. - : Nature Portfolio. - 2041-1723. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes. Loss of pancreatic beta cells is a central feature of type 1 (T1D) and type 2 (T2D) diabetes, but a therapeutic strategy to preserve beta cell mass remains to be established. Here we show that the death receptor TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction. Increased peripheral IGFBP3 was observed in established and at-risk T1D/T2D patients and was confirmed in T1D/T2D preclinical models, suggesting that dysfunctional IGFBP3/TMEM219 signaling is associated with abnormalities in beta cells homeostasis. In vitro and in vivo short-term IGFBP3/TMEM219 inhibition and TMEM219 genetic ablation preserved beta cells and prevented/delayed diabetes onset, while long-term IGFBP3/TMEM219 blockade allowed for beta cell expansion. Interestingly, in several patients cohorts restoration of appropriate IGFBP3 levels was associated with improved beta cell function. The IGFBP3/TMEM219 pathway is thus shown to be a physiological regulator of beta cell homeostasis and is also demonstrated to be disrupted in T1D/T2D. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes.
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  • Dal-Re, R, et al. (författare)
  • Making prospective registration of observational research a reality
  • 2014
  • Ingår i: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 6:224, s. 224cm1-
  • Tidskriftsartikel (refereegranskat)abstract
    • Key information about human observational studies should be publicly available before the study is initiated.
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  • El-Bousiydy, Hassna, et al. (författare)
  • LIBAC: An Annotated Corpus for Automated “Reading” of the Lithium-Ion Battery Research Literature
  • 2023
  • Ingår i: Chemistry of Materials. - : American Chemical Society (ACS). - 1520-5002 .- 0897-4756. ; 35:5, s. 1849-1857
  • Tidskriftsartikel (refereegranskat)abstract
    • The lithium-ion battery (LIB) research literature has increased very rapidly of late. While this is an immense source of valuable knowledge and facts for the community, these are also partly “buried” in the literature. To truly make the most possible use of the information available and automate “reading”, special tools are required. Named entity recognition (NER) is one such tool, which uses supervised machine learning for information extraction. To enable efficient NER, however, a large and high-quality annotated corpus is crucial. Here, we report on our generated, semi-automatically annotated lithium-ion battery annotated corpus, “LIBAC”, for 28 different entities of LIBs, which was used for training and evaluating Tok2vec and Transformer-based models, resulting in high general accuracies for these with F1-scores of 81 and 83%, respectively. LIBAC itself was created from 6985 paragraphs randomly chosen from ca. 11,000 LIB research papers and contains 73,300 annotated spans (627,428 tokens). This is the prime stepping-stone needed to develop a large-scale information extraction system designed for the LIB research literature.
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