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- Landegren, Ulf
(författare)
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Molecular tools to monitor health and disease - and lucky coincidences
- 2022
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Ingår i: Upsala Journal of Medical Sciences. - : Upsala Medical Society. - 0300-9734 .- 2000-1967. ; 127:1
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Forskningsöversikt (refereegranskat)abstract
- Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease. I will recount how I got started in this endeavor, and how our early work characterizing genetic variation led onto high-throughput protein measurements and to techniques for imaging the distribution of proteins and their activity states in tissues. I will also describe a more recent technique to measure even exceedingly rare genetic variants in order to monitor recurrence of disease for tumor patients.
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- Heynen, Martina, et al.
(författare)
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Facing different predators : adaptiveness of behavioral and morphological traits under predation
- 2017
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Ingår i: Current Zoology. - : OXFORD UNIV PRESS. - 1674-5507 .- 2396-9814. ; 63:3, s. 249-257
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Tidskriftsartikel (refereegranskat)abstract
- Predation is thought to be one of the main structuring forces in animal communities. However, selective predation is often measured on isolated traits in response to a single predatory species, but only rarely are selective forces on several traits quantified or even compared between different predators naturally occurring in the same system. In the present study, we therefore measured behavioral and morphological traits in young-of-the-year Eurasian perch Perca fluviatilis and compared their selective values in response to the 2 most common predators, adult perch and pike Esox lucius. Using mixed effects models and model averaging to analyze our data, we quantified and compared the selectivity of the 2 predators on the different morphological and behavioral traits. We found that selection on the behavioral traits was higher than on morphological traits and perch predators preyed overall more selectively than pike predators. Pike tended to positively select shallow bodied and nonvigilant individuals (i.e. individuals not performing predator inspection). In contrast, perch predators selected mainly for bolder juvenile perch (i.e. individuals spending more time in the open, more active), which was most important. Our results are to the best of our knowledge the first that analyzed behavioral and morphological adaptations of juvenile perch facing 2 different predation strategies. We found that relative specific predation intensity for the divergent traits differed between the predators, providing some additional ideas why juvenile perch display such a high degree of phenotypic plasticity.
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- Patel, Harshida, 1958, et al.
(författare)
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The Swedish Thematic Room Heart - a web-based knowledge forum
- 2011
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Ingår i: Scand Cardiovasc J. ; 45:S58
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Konferensbidrag (refereegranskat)abstract
- Background: The widespread use of web-based resources has dramatically increased access to scientifically based information. Access to large amounts of information places insurmountable demands on the readers to understand what is relevant and trustworthy. The Swedish research institute, Vårdal Institute took the initiative to set up a virtual room with the theme of cardiovascular care in Sweden, as part of a larger project encompassing nine virtual rooms with diverse health care themes. Methods: The aim of the project is to give an overview of the virtual thematic room and issues related to the dissemination of knowledge to patients, relatives, students and staff involved in cardiovascular care. Researchers and specialists in cardiology were invited to publish on the website in the space designated Thematic Room Heart. Results: Popular science articles are published in close cooperation between an editing committee and researchers. The virtual room presents reviews of recent research organized into the following themes: Coronary artery disease, arrhythmia, valve failure, heart failure, health economics, nutrition, physical activity, nutrition, geriatric and gender perspectives, and outpatient clinics run by nurses. In addition, the room contains news bulletin, information from patient organization and reference lists for text books, dissertations and guidelines. A syllabus and texts connected with each theme may be downloaded for use in local study circles. The idea is to stimulate the participants’ interest in learning in different contexts. The “current profile” and “good example” presentations are constantly updated. As this particular website is part of a larger virtual project, links and references to related issues such as “Living with chronic pain” and “Nutrition and eating” can easily be created. Conclusion: In conclusion, the virtual thematic room is a flexible, web-based anthology of interest and relevance to a wide range of readers interested in cardiovascular care.
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- Frandsen, Ann-Christine, 1959
(författare)
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Leva med psoriasis - att lära känna och förhålla sig till det främmande
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna undersökning handlar om livet med psoriasis. Den bygger på fyra intervjuer med individer med diagnosen psoriasis. Tolkningsarbetet är baserat på idéer hämtade från Grounded theory (1967). Resultatet visar att det handlar om en grundläggande social process att lära känna och förhålla sig till det främmande. Rapportens huvudsakliga bidrag är att beskriva denna sociala process. Undersökningen ingår som en fördjupningsdel i en större rapport om PSO, en enhet som behandlar psoriasis vid Sahlgrenska sjukhuset. Syftet med undersökningen är flera: att återapportera intervjuresultatet för PSO, att ge insikter om villkoren för individer med psoriasis och i förlängningen bidra till en diskussion kring de villkor detta ställer på vården och dess ekonomi. Rapporten är ett bakgrundsmaterial för min doktorsavhandling om redovisningens praktik och de processer som denna praktik ingår i. Den som får psoriasis ställs inför något främmande. Att lära känna och förhålla sig detta fenomen kan beskrivas som en process. De element som får processen att röra sig i en viss riktning är: medvetandets laboratorium, tankefigurer och handlingsalternativ. Om hudens förändringar, om än ovälkomna, till en viss grad kan accepteras ökar handlingsalternativen. Energi som tidigare har gått åt för att återskapa bilden om psoriasis som det icke friska, ger utrymme för andra tankar och handlingar. En viss acceptans kan ge individen med psoriasis helt andra möjligheter att leva sitt liv. Jag har också pekat på några övriga aspekter om hur det är att leva med psoriasis exempelvis en del utgifterna som individen har i samband med läkarbesök, medicin och transporter.
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- Wienberg, Jes
(författare)
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Kaos i kaosforskningen
- 1990
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Ingår i: META: Medeltidsarkeologisk tidskrift. - 0348-7903. ; , s. 53-53
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Chaos in the chaos research: Reply to Stig Welinder, who commented in META 1989: 4 on the article Jes Wienberg, "Kaos i tiden", META 1989: 3
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