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| 2. |
- Benetou, V, et al.
(författare)
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Mediterranean diet and incidence of hip fractures in a European cohort
- 2013
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Ingår i: Osteoporosis International. - : Springer London. - 0937-941X .- 1433-2965. ; 24:5, s. 1587-1598
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Tidskriftsartikel (refereegranskat)abstract
- Prevention of hip fractures is of critical public health importance. In a cohort of adults from eight European countries, evidence was found that increased adherence to Mediterranean diet, measured by a 10-unit dietary score, is associated with reduced hip fracture incidence, particularly among men. INTRODUCTION: Evidence on the role of dietary patterns on hip fracture incidence is scarce. We explored the association of adherence to Mediterranean diet (MD) with hip fracture incidence in a cohort from eight European countries. METHODS: A total of 188,795 eligible participants (48,814 men and 139,981 women) in the European Prospective Investigation into Cancer and nutrition study with mean age 48.6 years (±10.8) were followed for a median of 9 years, and 802 incident hip fractures were recorded. Diet was assessed at baseline through validated dietary instruments. Adherence to MD was evaluated by a MD score (MDs), on a 10-point scale, in which monounsaturated were substituted with unsaturated lipids. Association with hip fracture incidence was assessed through Cox regression with adjustment for potential confounders. RESULTS: Increased adherence to MD was associated with a 7 % decrease in hip fracture incidence [hazard ratio (HR) per 1-unit increase in the MDs 0.93; 95 % confidence interval (95 % CI) = 0.89-0.98]. This association was more evident among men and somewhat stronger among older individuals. Using increments close to one standard deviation of daily intake, in the overall sample, high vegetable (HR = 0.86; 95 % CI = 0.79-0.94) and high fruit (HR = 0.89; 95 % CI = 0.82-0.97) intake was associated with decreased hip fracture incidence, whereas high meat intake (HR = 1.18; 95 % CI = 1.06-1.31) with increased incidence. Excessive ethanol consumption (HR high versus moderate = 1.74; 95 % CI = 1.32-2.31) was also a risk factor. CONCLUSIONS: In a prospective study of adults, increased adherence to MD appears to protect against hip fracture occurrence, particularly among men.
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| 3. |
- Boström, Cecilia, et al.
(författare)
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Experimental Results From an Offshore Wave Energy Converter
- 2010
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Ingår i: Journal of Offshore Mechanics and Arctic Engineering-Transactions of The Asme. - : ASME International. - 0892-7219 .- 1528-896X. ; 132:4, s. 041103-
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Tidskriftsartikel (refereegranskat)abstract
- An offshore wave energy converter (WEC) was successfully launched at the Swedish west coast in the middle of March 2006. The WEC is based on a permanent magnet linear generator located on the sea floor driven by a point absorber. A measuring station has been installed on a nearby island where all measurements and experiments on the WEC have been carried out. The output voltage from the generator fluctuates both in amplitude and frequency and must therefore be converted to enable grid connection. In order to study the voltage conversion, the measuring station was fitted with a six pulse diode rectifier and a capacitive filter during the autumn of 2006. The object of this paper is to present a detailed description of the Lysekil research site. Special attention will be given to the power absorption by the generator when it is connected to a nonlinear load.
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| 4. |
- Boström, Cecilia, et al.
(författare)
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Temperature measurements in a linear generator and marine substation for wave power
- 2010
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Ingår i: PROCEEDINGS OF THE ASME 29TH INTERNATIONAL CONFERENCE ON OCEAN, OFFSHORE AND ARCTIC ENGINEERING 2010, VOL 3. - 9780791849118 ; , s. 545-552
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Konferensbidrag (refereegranskat)abstract
- This paper analyzes temperature measurements acquired in offshore operation of a wave energy converter array. The three directly driven wave energy converters have linear generators and are connected to a marine substation placed on the seabed. The highly irregular individual linear generator voltages are rectified and added on a common DC-link and inverted to 50 Hz to facilitate future grid-connection. The electrical power is transmitted to shore and converted to heat in a measuring station. First results of temperature measurements on substation components and on the stator of one of the linear generators are presented from operation in linear and in non-linear damping. Results indicate that there might be some convective heat transport in the substation vessel. If high power levels are extracted from the waves, this has to be considered when placing components in the substation vessel to avoid heating from neighbouring components. The results also indicate that the temperature increase in the linear generator stator is very small. Failure due to excessive heating of the stator winding PVC cable insulation is unlikely to occur even in very energetic sea states. Should this conclusion be incorrect, the thermal conductivity between the stator and the hull of the WEC could be enhanced. Another suggested alteration would be to lower the resistive losses by reducing the linear generator current density.
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| 5. |
- Boström, Cecilia, et al.
(författare)
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Temperature measurements in a linear generator and marine substation for wave power
- 2012
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Ingår i: Journal of Offshore Mechanics and Arctic Engineering-Transactions of The Asme. - : ASME International. - 0892-7219 .- 1528-896X. ; 134:2, s. 021901-
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Tidskriftsartikel (refereegranskat)abstract
- This paper analyzes temperature measurements acquired in the offshore operation of a wave energy converter array. The three directly driven wave energy converters have linear generators and are connected to a marine substation placed on the seabed. The highly irregular individual linear generator voltages are rectified and added on a common dc-link and inverted to 50 Hz to facilitate future grid-connection. The electrical power is transmitted to shore and converted to heat in a measuring station. The first results of temperature measurements on substation components and on the stator of one of the linear generators are presented based on operation in linear and in nonlinear damping. The results indicate that there might be some convective heat transfer in the substation vessel. If high power levels are extracted from the waves, this has to be considered when placing components in the substation vessel in order to avoid heating from neighboring components. The results also indicate that the temperature increase in the linear generator stator is very small. Failure due to excessive heating of the stator winding polyvinyl chloride cable insulation is unlikely to occur even in very energetic sea states. Should this conclusion be incorrect, the thermal conductivity between the stator and the hull of the wave energy converter could be enhanced. Another suggested alteration is to lower the resistive losses by reducing the linear generator current density.
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| 6. |
- Castellucci, Valeria, et al.
(författare)
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Algorithm for the Calculation of the Translator Position in Permanent Magnet Linear Generators
- 2014
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Ingår i: Journal of Renewable and Sustainable Energy. - : AIP Publishing. - 1941-7012. ; 6:6, s. 063102-
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Tidskriftsartikel (refereegranskat)abstract
- A permanent magnet linear generator for direct drive wave energy converters is a suitable power take-off system for ocean wave energy extraction, especially when coupled with a point absorbing buoy via a connection line. The performance of the linear generator is affected by the excursion of the translator along the stator. The optimal stroke is achieved when the midpoint of the oscillations coincides with the center of the stator. However, sea level changes due to, e.g., tides will shift these oscillations. This paper proposes a model able to detect the position of the translator from the generator output voltage. The algorithm will be integrated in the control system of a mechanical device that adjusts the length of the connection line in order to center the average position of the translator with the center of the stator. Thereby, the output power from the wave energy converter increases, and the mechanical stresses on the hull of the generator decrease. The results obtained by the model show good agreement with the experimental results from two linear generators, L2 and L3, deployed in the Lysekil wave energy research site, Sweden. The theoretical results differ from the experimental results by −4 mm for L2 and 21 mm for L3 with a standard deviation of 27 mm and 31 mm, respectively.
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| 7. |
- Conaway, H Herschel, et al.
(författare)
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Retinoids stimulate periosteal bone resorption by enhancing the protein RANKL, a response inhibited by monomeric glucocorticoid receptor.
- 2011
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Ingår i: The Journal of biological chemistry. - 1083-351X .- 0021-9258. ; 286:36, s. 31425-36
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Tidskriftsartikel (refereegranskat)abstract
- Increased vitamin A (retinol) intake has been suggested to increase bone fragility. In the present study, we investigated effects of retinoids on bone resorption in cultured neonatal mouse calvarial bones and their interaction with glucocorticoids (GC). All-trans-retinoic acid (ATRA), retinol, retinalaldehyde, and 9-cis-retinoic acid stimulated release of (45)Ca from calvarial bones. The resorptive effect of ATRA was characterized by mRNA expression of genes associated with osteoclast differentiation, enhanced osteoclast number, and bone matrix degradation. In addition, the RANKL/OPG ratio was increased by ATRA, release of (45)Ca stimulated by ATRA was blocked by exogenous OPG, and mRNA expression of genes associated with bone formation was decreased by ATRA. All retinoid acid receptors (RARα/β/γ) were expressed in calvarial bones. Agonists with affinity to all receptor subtypes or specifically to RARα enhanced the release of (45)Ca and mRNA expression of Rankl, whereas agonists with affinity to RARβ/γ or RARγ had no effects. Stimulation of Rankl mRNA by ATRA was competitively inhibited by the RARα antagonist GR110. Exposure of calvarial bones to GC inhibited the stimulatory effects of ATRA on (45)Ca release and Rankl mRNA and protein expression. This inhibitory effect was reversed by the glucocorticoid receptor (GR) antagonist RU 486. Increased Rankl mRNA stimulated by ATRA was also blocked by GC in calvarial bones from mice with a GR mutation that blocks dimerization (GR(dim) mice). The data suggest that ATRA enhances periosteal bone resorption by increasing the RANKL/OPG ratio via RARα receptors, a response that can be inhibited by monomeric GR.
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| 8. |
- Crnalic, Sead, et al.
(författare)
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Early diagnosis and treatment is crucial for neurological recovery after surgery for metastatic spinal cord compression in prostate cancer
- 2013
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Ingår i: Acta Oncologica. - London : Informa Healthcare. - 0284-186X .- 1651-226X. ; 52:4, s. 809-815
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Tidskriftsartikel (refereegranskat)abstract
- Background. Spinal cord compression is an oncological and surgical emergency. Delays in referral and diagnosis may influence functional outcome. It is therefore important to identify patients who will regain or maintain ability to walk after surgery. The aim of the present study was to examine current practice for referral and diagnosis of prostate cancer patients with spinal cord compression and to identify prognostic factors for neurological outcome after surgery.Patients and methods. The study includes 68 consecutive patients with prostate cancer who underwent surgery due to neurological compromise. Intervals from onset of neurological symptoms to referral, diagnosis, and treatment were analyzed in relation to functional outcome. The prognostic significance of preoperative clinical parameters on gait function one month after surgery was evaluated.Results. Patients who were referred from local hospitals had longer delay to surgery than those who directly presented to the cancer centre (p=0.004). The rate of diagnosis with MRI increased through the week and peaked on Friday, with few patients being diagnosed during weekends. Ability to walk before surgery, hormone-naive prostate cancer, and/or shorter time from loss of ambulation were associated with more favorable neurological outcome. In patients with hormone-refractory disease who were unable to walk before surgery regaining of ambulation was associated with: duration of paresis <48 hours (p=0.005), good preoperative performance status (p=0.04), preoperative PSA serum level <200 ng/ml (p=0.03), and surgery with posterior decompression and stabilization (p=0.03).Conclusion. Early diagnosis and rapid treatment of spinal cord compression in prostate cancer patients is crucial for neurological recovery. Rising of awareness for the condition among patients at risk and among physicians is mandatory as well as improvement of local and regional guidelines for treatment.
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| 9. |
- Crnalic, Sead, et al.
(författare)
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Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patients
- 2010
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Ingår i: Endocrine-Related Cancer. - 1351-0088 .- 1479-6821. ; 17:4, s. 885-895
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Tidskriftsartikel (refereegranskat)abstract
- Androgen receptors (ARs) are probably of importance during all phases of prostate cancer (PC) growth, but their role in bone metastases is largely unexplored. Bone metastases were therefore collected from hormone-naive (n=11), short-term castrated (n=7) and castration-resistant PC (CRPC, n=44) patients by biopsy (n=4) or at surgery to alleviate symptoms from metastases complications (metastasis surgery, n=58), and immunostained for nuclear ARs, Ki67, active caspase-3, prostate-specific antigen (PSA) and chromogranin A, and results were related to serum PSA, treatments and outcome. Nuclear AR immunostaining was decreased and apoptosis was increased, but cell proliferation remained largely unaffected in metastases within a few days after surgical castration. In CRPC patients, nuclear AR staining of metastases was increased when compared to short-term castrated patients. The nuclear AR staining score was related to tumour cell proliferation, but it was not associated with other downstream effects of AR activation such as apoptosis and PSA staining, and it was only marginally related to the presence of neuroendocrine tumour cells. Serum PSA at metastasis surgery, although related to outcome, was not associated with AR staining, markers of metastasis growth or PSA staining in metastases. High nuclear AR immunostaining was associated with a particularly poor prognosis after metastasis surgery in CRPC patients, suggesting that such men may benefit from the potent AR blockers now tested in clinical trials.
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| 10. |
- Ekström, Rickard, et al.
(författare)
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Evaluating Constant DC-Link Operation of Wave Energy Converter
- 2012
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Ingår i: Proceedings of the 31st ASME International Conference on Ocean, Offshore and Arctic Engineering, vol. 7. - 9780791844946 ; , s. 269-276
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Konferensbidrag (refereegranskat)abstract
- A Wave Energy Converter (WEC) based on a linear generator and a point-absorbing buoy has been developed at Uppsala University. Interconnecting an array of WECs in parallel requires a point of common coupling, such as a common DC-bus. The DC voltage level seen by the generator is directly linked to the electromagnetic damping of the generator A lower DC-level results in a higher damping factor and is important for increased absorption of the wave power The drawback is increased losses in generator windings and cable resistance. There will be an optimal DC-level for maximum power output. This is a function of not only generator and buoy characteristics, but the current sea state. Experimental results of the full-scale system have been carried out, and used as validation of a simulation model of the system. The model is then used to evaluate how the DC-level seen by the generator influence the power output. The results indicate that higher DC-levels should be used at higher sea states, and power output may vary by up to a factor five depending on which DC-level is chosen.
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