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Occupational Exposu...
Occupational Exposure and New-onset Asthma in a Population-based Study in Northern Europe (RHINE)
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- Lillienberg, Linnea, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Andersson, Eva, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Janson, Christer (author)
- Uppsala universitet,Lungmedicin och allergologi
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- Dahlman-Höglund, Anna, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Forsberg, Bertil (author)
- Umeå universitet,Yrkes- och miljömedicin,Arcum
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- Holm, Mathias, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Gislason, Thorarinn (author)
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- Jõgi, Rain (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Lungmedicin och allergologi
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Omenaas, Ernst (author)
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Schlunssen, Vivi (author)
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Sigsgaard, Torben (author)
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Svanes, Cecilie (author)
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- Torén, Kjell, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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(creator_code:org_t)
- 2012-12-01
- 2013
- English.
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In: Annals of Occupational Hygiene. - Oxford : Oxford University Press (OUP). - 0003-4878 .- 1475-3162. ; 57:4, s. 482-492
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https://doi.org/10.1...
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Abstract
Subject headings
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- In a large population-based study among adults in northern Europe the relation between occupational exposure and new-onset asthma was studied. The study comprised 13 284 subjects born between 1945 and 1973, who answered a questionnaire 19891992 and again 19992001. Asthma was defined as Asthma diagnosed by a physician with reported year of diagnose. Hazard ratios (HR), for new-onset adult asthma during 19802000, were calculated using a modified job-exposure matrix as well as high-risk occupations in Cox regression models. The analyses were made separately for men and women and were also stratified for atopy. During the observation period there were 429 subjects with new-onset asthma with an asthma incidence of 1.3 cases per 1000 person-years for men and 2.4 for women. A significant increase in new-onset asthma was seen for men exposed to plant-associated antigens (HR 3.6; 95% CI [confidence interval] 1.49.0), epoxy (HR 2.4; 95% CI 1.34.5), diisocyanates (HR 2.1; 95% CI 1.23.7) and accidental peak exposures to irritants (HR 2.4; 95% CI 1.34.7). Both men and women exposed to cleaning agents had an increased asthma risk. When stratifying for atopy an increased asthma risk were seen in non-atopic men exposed to acrylates (HR 3.3; 95% CI 1.47.5), epoxy compounds (HR 3.6; 95% CI 1.67.9), diisocyanates and accidental peak exposures to irritants (HR 3.0; 95% CI 1.27.2). Population attributable risk for occupational asthma was 14% for men and 7% for women. This population-based study showed that men exposed to epoxy, diisocyanates and acrylates had an increased risk of new-onset asthma. Non-atopics seemed to be at higher risk than atopics, except for exposure to high molecular weight agents. Increased asthma risks among cleaners, spray painters, plumbers, and hairdressers were confirmed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Atopics and non-atopics
- high molecular weight agent
- high-risk occupations
- irritating agents
- job-exposure matrix
- low molecualr weight agent
- occupational asthma
- population attributable risk
- Atopics and non-atopics; high molecular weight agent; high-risk occupations; irritating agents; job-exposure matrix; low molecualr weight agent; occupational asthma; population attributable risk
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lillienberg, Lin ...
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Andersson, Eva, ...
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Janson, Christer
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Dahlman-Höglund, ...
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Forsberg, Bertil
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Holm, Mathias, 1 ...
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Gislason, Thorar ...
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Jõgi, Rain
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Omenaas, Ernst
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Schlunssen, Vivi
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Sigsgaard, Torbe ...
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Svanes, Cecilie
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Torén, Kjell, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Annals of Occupa ...
- By the university
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Uppsala University
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Umeå University
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University of Gothenburg