Sökning: (L773:0021 972X OR L773:1945 7197) srt2:(1990-1994)
> (1991) >
Multiple endocrine ...
Multiple endocrine neoplasia type 1 : a ten year prospective screening study in four kindreds
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- Skogseid, Britt (författare)
- Uppsala universitet,Medicin
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- Eriksson, Barbro (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Ludwiginstitutet för cancerforskning,Endokrin tumörbiologi
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- Lundqvist, Gudmar (författare)
- Uppsala universitet,Klinisk kemi
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- Lörelius, Lars Erik (författare)
- Uppsala universitet,Enheten för radiologi
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- Rastad, Jonas (författare)
- Uppsala universitet,Endokrinkirurgi
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- Wide, Leif (författare)
- Uppsala universitet,Klinisk kemi
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- Åkerström, Göran (författare)
- Uppsala universitet,Endokrinkirurgi
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- Öberg, Kjell (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Ludwiginstitutet för cancerforskning,Onkologisk endokrinologi
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(creator_code:org_t)
- The Endocrine Society, 1991
- 1991
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 73:2, s. 281-287
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A total of 80 individuals in 4 kindreds with multiple endocrine neoplasia type 1 (MEN 1) have been subjected to repeated biochemical screening during a 10-yr period with the principal aim being to analyze characteristics of the developing pancreatic lesion. Age at presentation of the MEN 1 trait averaged 18 yr in 7 previously unaffected individuals, and this effect of the screening procedure represented a lowering by almost 2 decades. Pancreatic endocrine involvement was recognized at a mean age of 25 yr and constituted the presenting lesion in a majority of the patients. A standardized meal test and basal values of serum pancreatic polypeptide, insulin, proinsulin, and gastrin were the most efficient markers for the pancreatic lesion and preceded signs of pancreatic tumors upon radiological examinations by a mean of 3.5 yr. A 75% penetrance of the islet cell disease and 90% for primary hyperparathyroidism within the affected individuals equalled the prevalences reported in autopsy studies. Two of the kindreds showed signs of intrafamilial homogeneity with respect to the profile of peptide excess (P less than 0.05) and considerable discrepancy in the malignant potential of the pancreatic lesions. The results of early detection and surgical intervention of the pancreatic tumors in MEN 1 suggested an impact on morbidity, while any effect on the mortality of these individuals remains to be clarified.
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- art (ämneskategori)
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