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Träfflista för sökning "(L773:1087 0156 OR L773:1546 1696) srt2:(2015-2019) srt2:(2016)"

Search: (L773:1087 0156 OR L773:1546 1696) srt2:(2015-2019) > (2016)

Result 1-8 of 8

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1.	Albers, Stevan C., et al. (author) The rise and fall of innovation in biofuels 2016 In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 34:8, s. 814-821 Journal article (peer-reviewed)
2.	Amit, Ido, et al. (author) Voices of biotech 2016 In: Nature Biotechnology. - : Nature Publishing Group. - 1087-0156 .- 1546-1696. ; 34:3, s. 270-275 Journal article (peer-reviewed)
3.	Cadwell, CR, et al. (author) Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq 2016 In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 34:2, s. 199- Journal article (peer-reviewed)
4.	Egelie, K. J., et al. (author) The emerging patent landscape of CRISPR-Cas gene editing technology 2016 In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 34:10, s. 1025-1032 Journal article (peer-reviewed)abstract Early views on the control of the CRISPR-Cas disruptive enabling technology and access for follow-on commercial applications.
5.	Faridani, OR, et al. (author) Single-cell sequencing of the small-RNA transcriptome 2016 In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 34:12, s. 1264-1266 Journal article (peer-reviewed)
6.	Fuzik, J, et al. (author) Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes 2016 In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 34:2, s. 175- Journal article (peer-reviewed)
7.	Mooijman, D, et al. (author) Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction 2016 In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 34:8, s. 852- Journal article (peer-reviewed)
8.	Olofsson, Peder S., et al. (author) Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase 2016 In: Nature Biotechnology. - : Nature Publishing Group. - 1087-0156 .- 1546-1696. ; 34:10, s. 1066-1071 Journal article (peer-reviewed)abstract Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4(+) T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals(1). Here we show that these CD4(+)CD44(hi)CD62L(Io) T helper cells by gene expression are a distinct T-cell population defined by ChAT (CD4 T-ChAT). Mice lacking ChAT expression in CD4(+) cells have elevated arterial blood pressure, compared to littermate controls. Jurkat T cells overexpressing ChAT (JT(ChAT)) decreased blood pressure when infused into mice. Co-incubation of JT(ChAT) and endothelial cells increased endothelial cell levels of phosphorylated endothelial nitric oxide synthase, and of nitrates and nitrites in conditioned media, indicating increased release of the potent vasorelaxant nitric oxide. The isolation and characterization of CD4 T-ChAT cells will enable analysis of the role of these cells in hypotension and hypertension, and may suggest novel therapeutic strategies by targeting cell-mediated vasorelaxation.

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Result 1-8 of 8

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Type of publication: journal article (8)

Type of content: peer-reviewed (8)

Author/Editor: Sandberg, R (2); Graff, Gregory, 1969 (2); Yilmaz, M. (1); Linnarsson, S (1); Abdullayev, I (1); Andersson, Ulf (1); show more...; Arner, Anders (1); Shen, S (1); Lundberg, Emma (1); Gregersen, Peter K. (1); Harkany, T (1); Albers, Stevan C. (1); Berklund, Annabelle ... (1); Calvigioni, D (1); Fuzik, J (1); Mate, Z (1); Szabo, G (1); Crosetto, N (1); Amit, Ido (1); Zhang, Tian (1); Johansen, B (1); Deng, QL (1); Faridani, OR (1); Lövdahl, Cecilia (1); Lanner, F (1); Yanagawa, Y (1); Hagemann-Jensen, M (1); Broliden, Kristina (1); Olofsson, Peder S. (1); Diamond, Betty (1); Cadwell, CR (1); Tolias, KF (1); Berens, P (1); Jiang, XL (1); Tolias, AS (1); Palasantza, A (1); Reimer, J (1); Bethge, M (1); Schell, JP (1); Zeisel, A (1); van Oudenaarden, A (1); Chavan, Sangeeta S (1); Pavlov, Valentin A (1); Tracey, Kevin J (1); Szekeres, Ferenc (1); Egelie, K. J. (1); Strand, S. P. (1); Rothstein, Thomas L (1); Introini, Andrea (1); Dey, SS (1); show less...

University: Karolinska Institutet (5); Chalmers University of Technology (2); Royal Institute of Technology (1); University of Skövde (1)

Language: English (8)

Research subject (UKÄ/SCB): Natural sciences (3); Engineering and Technology (2); Medical and Health Sciences (1)

Year: 2016 (8)Undo refine

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